BRD-A20243730_Danazol_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-A20243730_Danazol_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ADAM9 ADAM metallopeptidase domain 9
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ARL4C ADP-ribosylation factor-like 4C
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BSG basigin (Ok blood group)
C5AR1 complement component 5a receptor 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL4 chemokine (C-C motif) ligand 4
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CLEC5A C-type lectin domain family 5, member A
CLEC7A C-type lectin domain family 7, member A
COLEC12 collectin sub-family member 12
CTNND1 catenin (cadherin-associated protein), delta 1
CYTIP cytohesin 1 interacting protein
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DOCK4 dedicator of cytokinesis 4
EMX2 empty spiracles homeobox 2
GJA1 gap junction protein, alpha 1, 43kDa
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GRB7 growth factor receptor-bound protein 7
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUSBP3 glucuronidase, beta pseudogene 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IGL immunoglobulin lambda locus
IL32 interleukin 32
JUP junction plakoglobin
KRT6B keratin 6B, type II
LIMCH1 LIM and calponin homology domains 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LPAR6 lysophosphatidic acid receptor 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MB myoglobin
MT1M metallothionein 1M
MTA1 metastasis associated 1
NAMPT nicotinamide phosphoribosyltransferase
NDFIP1 Nedd4 family interacting protein 1
NRCAM neuronal cell adhesion molecule
P3H2 prolyl 3-hydroxylase 2
PAPD7 PAP associated domain containing 7
PDE4B phosphodiesterase 4B, cAMP-specific
PERP PERP, TP53 apoptosis effector
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PMM2 phosphomannomutase 2
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
PTPRE protein tyrosine phosphatase, receptor type, E
PTPRK protein tyrosine phosphatase, receptor type, K
RAB27A RAB27A, member RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RTN2 reticulon 2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SDC1 syndecan 1
SEPP1 selenoprotein P, plasma, 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SOD2 superoxide dismutase 2, mitochondrial
SPON2 spondin 2, extracellular matrix protein
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
STON1 stonin 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TRDV3 T cell receptor delta variable 3
VEGFA vascular endothelial growth factor A
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AQP1 aquaporin 1 (Colton blood group)
BST2 bone marrow stromal cell antigen 2
CAPN3 calpain 3, (p94)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CHPT1 choline phosphotransferase 1
COL9A3 collagen, type IX, alpha 3
CORO1C coronin, actin binding protein, 1C
CPVL carboxypeptidase, vitellogenic-like
CXCL5 chemokine (C-X-C motif) ligand 5
CYBA cytochrome b-245, alpha polypeptide
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCBLD2 discoidin, CUB and LCCL domain containing 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FLNA filamin A, alpha
GNAS GNAS complex locus
GSTM3 glutathione S-transferase mu 3 (brain)
HOXC6 homeobox C6
IL6ST interleukin 6 signal transducer
KPNB1 karyopherin (importin) beta 1
LAMP1 lysosomal-associated membrane protein 1
LUC7L3 LUC7-like 3 (S. cerevisiae)
MALL mal, T-cell differentiation protein-like
MBP myelin basic protein
MTDH metadherin
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUP210 nucleoporin 210kDa
RBM25 RNA binding motif protein 25
RPS11 ribosomal protein S11
S100A10 S100 calcium binding protein A10
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC46A3 solute carrier family 46, member 3
SPTBN1 spectrin, beta, non-erythrocytic 1
SRPX sushi-repeat containing protein, X-linked
STOM stomatin
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TKTL1 transketolase-like 1
TSPAN31 tetraspanin 31
ZBTB18 zinc finger and BTB domain containing 18
Funding