BRD-A22032524_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

110 genes differentially expressed following the BRD-A22032524_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACSL1 acyl-CoA synthetase long-chain family member 1
AK1 adenylate kinase 1
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP2A3 ATPase, Ca++ transporting, ubiquitous
AUTS2 autism susceptibility candidate 2
BASP1 brain abundant, membrane attached signal protein 1
BNC2 basonuclin 2
C10ORF10 chromosome 10 open reading frame 10
CAPG capping protein (actin filament), gelsolin-like
CD52 CD52 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CECR1 cat eye syndrome chromosome region, candidate 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CXCL9 chemokine (C-X-C motif) ligand 9
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DUSP4 dual specificity phosphatase 4
EFNA1 ephrin-A1
ETV1 ets variant 1
FTH1 ferritin, heavy polypeptide 1
GDF15 growth differentiation factor 15
GNPDA1 glucosamine-6-phosphate deaminase 1
GPR183 G protein-coupled receptor 183
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
IFI30 interferon, gamma-inducible protein 30
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
LRRC15 leucine rich repeat containing 15
MAP7 microtubule-associated protein 7
MYO1D myosin ID
MZB1 marginal zone B and B1 cell-specific protein
NAV2 neuron navigator 2
NBPF10 neuroblastoma breakpoint family, member 10
NID2 nidogen 2 (osteonidogen)
NKX2-1 NK2 homeobox 1
NNMT nicotinamide N-methyltransferase
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
PBX3 pre-B-cell leukemia homeobox 3
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG10 paternally expressed 10
POU2AF1 POU class 2 associating factor 1
RAD23B RAD23 homolog B (S. cerevisiae)
RGS1 regulator of G-protein signaling 1
RGS16 regulator of G-protein signaling 16
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SGK1 serum/glucocorticoid regulated kinase 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC16A6 solute carrier family 16, member 6
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A1 solute carrier family 38, member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SORBS2 sorbin and SH3 domain containing 2
SQSTM1 sequestosome 1
SULF1 sulfatase 1
TMSB15A thymosin beta 15a
TSC22D1 TSC22 domain family, member 1
WARS tryptophanyl-tRNA synthetase
YARS tyrosyl-tRNA synthetase
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA1 annexin A1
AQP3 aquaporin 3 (Gill blood group)
CD99 CD99 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CLTB clathrin, light chain B
CNN3 calponin 3, acidic
COCH cochlin
COL21A1 collagen, type XXI, alpha 1
COPS7A COP9 signalosome subunit 7A
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL5 chemokine (C-X-C motif) ligand 5
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP7 dual specificity phosphatase 7
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FOLR1 folate receptor 1 (adult)
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GJA1 gap junction protein, alpha 1, 43kDa
GSTA4 glutathione S-transferase alpha 4
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IL17RB interleukin 17 receptor B
OLFM4 olfactomedin 4
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PON2 paraoxonase 2
PRKCA protein kinase C, alpha
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGS2 regulator of G-protein signaling 2
RPIA ribose 5-phosphate isomerase A
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SORD sorbitol dehydrogenase
SRSF6 serine/arginine-rich splicing factor 6
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR3 transforming growth factor, beta receptor III
TNC tenascin C
TSPAN8 tetraspanin 8
TUBB2A tubulin, beta 2A class IIa
ZW10 zw10 kinetochore protein
Funding