BRD-A22032524_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

103 genes differentially expressed following the BRD-A22032524_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGTR1 angiotensin II receptor, type 1
AKR1C3 aldo-keto reductase family 1, member C3
ASNS asparagine synthetase (glutamine-hydrolyzing)
AUTS2 autism susceptibility candidate 2
CCNG2 cyclin G2
CD24 CD24 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLIC4 chloride intracellular channel 4
CLIC5 chloride intracellular channel 5
COL10A1 collagen, type X, alpha 1
CYB5A cytochrome b5 type A (microsomal)
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DPYSL2 dihydropyrimidinase-like 2
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP3 dual specificity phosphatase 3
EBP emopamil binding protein (sterol isomerase)
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
IL32 interleukin 32
INSIG1 insulin induced gene 1
L1CAM L1 cell adhesion molecule
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MFAP5 microfibrillar associated protein 5
MMP2 matrix metallopeptidase 2
MSMO1 methylsterol monooxygenase 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUPR1 nuclear protein, transcriptional regulator, 1
PEG10 paternally expressed 10
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRSS8 protease, serine, 8
PSPH phosphoserine phosphatase
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQLE squalene epoxidase
SQSTM1 sequestosome 1
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TRIB3 tribbles pseudokinase 3

decreased expression

Symbol Name
ANO1 anoctamin 1, calcium activated chloride channel
APOD apolipoprotein D
AREG amphiregulin
CCND2 cyclin D2
CDC25A cell division cycle 25A
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CYBA cytochrome b-245, alpha polypeptide
EGFR epidermal growth factor receptor
EIF4A1 eukaryotic translation initiation factor 4A1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
G0S2 G0/G1 switch 2
GATA2 GATA binding protein 2
GOLGA8A golgin A8 family, member A
HMG20B high mobility group 20B
HOXC6 homeobox C6
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
ITM2A integral membrane protein 2A
KIAA0485 uncharacterized LOC57235
KLHL21 kelch-like family member 21
MPO myeloperoxidase
MT1X metallothionein 1X
NDN necdin, melanoma antigen (MAGE) family member
NID2 nidogen 2 (osteonidogen)
NOLC1 nucleolar and coiled-body phosphoprotein 1
PDE4B phosphodiesterase 4B, cAMP-specific
PLK1 polo-like kinase 1
PTCH1 patched 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAD23B RAD23 homolog B (S. cerevisiae)
RBP1 retinol binding protein 1, cellular
RGS2 regulator of G-protein signaling 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SPDEF SAM pointed domain containing ETS transcription factor
SRSF7 serine/arginine-rich splicing factor 7
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI2 tissue factor pathway inhibitor 2
TNC tenascin C
XIST X inactive specific transcript (non-protein coding)
Funding