BRD-A24054354_-666_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

144 genes differentially expressed following the BRD-A24054354_-666_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADGRG6 adhesion G protein-coupled receptor G6
AMOTL2 angiomotin like 2
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
CBS cystathionine-beta-synthase
CCL20 chemokine (C-C motif) ligand 20
CD93 CD93 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CSDE1 cold shock domain containing E1, RNA-binding
CSRP1 cysteine and glycine-rich protein 1
DDIT4 DNA-damage-inducible transcript 4
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DHRS7 dehydrogenase/reductase (SDR family) member 7
DUSP6 dual specificity phosphatase 6
EMP1 epithelial membrane protein 1
EPRS glutamyl-prolyl-tRNA synthetase
EXT1 exostosin glycosyltransferase 1
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GBP1 guanylate binding protein 1, interferon-inducible
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GUSBP11 glucuronidase, beta pseudogene 11
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-B major histocompatibility complex, class I, B
HLA-E major histocompatibility complex, class I, E
IARS isoleucyl-tRNA synthetase
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGL immunoglobulin lambda locus
IL1A interleukin 1, alpha
INHBA inhibin, beta A
KIAA0020 KIAA0020
KTN1 kinectin 1 (kinesin receptor)
KYNU kynureninase
LARP6 La ribonucleoprotein domain family, member 6
LIMA1 LIM domain and actin binding 1
MAP1B microtubule-associated protein 1B
MCL1 myeloid cell leukemia 1
MGLL monoglyceride lipase
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
NFIL3 nuclear factor, interleukin 3 regulated
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PSAT1 phosphoserine aminotransferase 1
PYCR1 pyrroline-5-carboxylate reductase 1
RDX radixin
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RIPK2 receptor-interacting serine-threonine kinase 2
RND3 Rho family GTPase 3
SARS seryl-tRNA synthetase
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STAT1 signal transducer and activator of transcription 1, 91kDa
STC2 stanniocalcin 2
STK38L serine/threonine kinase 38 like
STX1A syntaxin 1A (brain)
SYNJ2 synaptojanin 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNIP1 TNFAIP3 interacting protein 1
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
VWF von Willebrand factor
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase
ZFAND1 zinc finger, AN1-type domain 1

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
AMACR alpha-methylacyl-CoA racemase
AQP1 aquaporin 1 (Colton blood group)
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCND3 cyclin D3
CCNF cyclin F
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDK1 cyclin-dependent kinase 1
CDKN2A cyclin-dependent kinase inhibitor 2A
CPVL carboxypeptidase, vitellogenic-like
CRIP1 cysteine-rich protein 1 (intestinal)
CRYZ crystallin, zeta (quinone reductase)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
EDNRB endothelin receptor type B
FBXO9 F-box protein 9
FOLR1 folate receptor 1 (adult)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HES1 hes family bHLH transcription factor 1
HMGB3 high mobility group box 3
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA8 heat shock 70kDa protein 8
IL1R2 interleukin 1 receptor, type II
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INTS3 integrator complex subunit 3
KIF14 kinesin family member 14
LBH limb bud and heart development
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MCM5 minichromosome maintenance complex component 5
NPY neuropeptide Y
NTS neurotensin
PCNA proliferating cell nuclear antigen
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PHACTR2 phosphatase and actin regulator 2
PI3 peptidase inhibitor 3, skin-derived
PRKCQ protein kinase C, theta
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBP1 retinol binding protein 1, cellular
RPA3 replication protein A3, 14kDa
RPS11 ribosomal protein S11
RRM2 ribonucleotide reductase M2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC46A3 solute carrier family 46, member 3
SLPI secretory leukocyte peptidase inhibitor
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TCTN1 tectonic family member 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM2 transmembrane protein 2
TOX3 TOX high mobility group box family member 3
TSPAN8 tetraspanin 8
TUBB4B tubulin, beta 4B class IVb
VAV3 vav 3 guanine nucleotide exchange factor
ZBTB20 zinc finger and BTB domain containing 20
Funding