BRD-A24396574_celastrol_BT20_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

54 genes differentially expressed following the BRD-A24396574_celastrol_BT20_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AQP3 aquaporin 3 (Gill blood group)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
CH25H cholesterol 25-hydroxylase
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
HBD hemoglobin, delta
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
IFI30 interferon, gamma-inducible protein 30
KLF4 Kruppel-like factor 4 (gut)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
NR4A2 nuclear receptor subfamily 4, group A, member 2
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLBD1 phospholipase B domain containing 1
PLIN2 perilipin 2
RGS1 regulator of G-protein signaling 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFN stratifin
SLCO4A1 solute carrier organic anion transporter family, member 4A1
STC1 stanniocalcin 1
TOB1 transducer of ERBB2, 1
TPBG trophoblast glycoprotein
TRIP6 thyroid hormone receptor interactor 6
VCAM1 vascular cell adhesion molecule 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
CXCL2 chemokine (C-X-C motif) ligand 2
FLRT2 fibronectin leucine rich transmembrane protein 2
FST follistatin
GATA6 GATA binding protein 6
IGFBP6 insulin-like growth factor binding protein 6
LTBP2 latent transforming growth factor beta binding protein 2
MT1E metallothionein 1E
P3H2 prolyl 3-hydroxylase 2
PDGFD platelet derived growth factor D
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
POSTN periostin, osteoblast specific factor
PSIP1 PC4 and SFRS1 interacting protein 1
SCARB2 scavenger receptor class B, member 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
THBS1 thrombospondin 1
Funding