BRD-A24396574_celastrol_LNCAP_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

267 genes differentially expressed following the BRD-A24396574_celastrol_LNCAP_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AIF1 allograft inflammatory factor 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALAS1 5'-aminolevulinate synthase 1
ALCAM activated leukocyte cell adhesion molecule
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDOC aldolase C, fructose-bisphosphate
AMDHD2 amidohydrolase domain containing 2
ANGPT2 angiopoietin 2
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BEX1 brain expressed, X-linked 1
BLVRB biliverdin reductase B
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CBR3 carbonyl reductase 3
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CP ceruloplasmin (ferroxidase)
CTSA cathepsin A
CTSD cathepsin D
CTTN cortactin
ECM1 extracellular matrix protein 1
EGF epidermal growth factor
ELL2 elongation factor, RNA polymerase II, 2
ENO2 enolase 2 (gamma, neuronal)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM134B family with sequence similarity 134, member B
FAM46A family with sequence similarity 46, member A
FAM63A family with sequence similarity 63, member A
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GAB2 GRB2-associated binding protein 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GJA1 gap junction protein, alpha 1, 43kDa
GRB10 growth factor receptor-bound protein 10
GRN granulin
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
IGFBP3 insulin-like growth factor binding protein 3
ITM2A integral membrane protein 2A
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
LAMP2 lysosomal-associated membrane protein 2
LDB2 LIM domain binding 2
LRP10 low density lipoprotein receptor-related protein 10
LY96 lymphocyte antigen 96
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
MUC1 mucin 1, cell surface associated
MVP major vault protein
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NR0B1 nuclear receptor subfamily 0, group B, member 1
NRCAM neuronal cell adhesion molecule
PNMA2 paraneoplastic Ma antigen 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PRAF2 PRA1 domain family, member 2
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PXDN peroxidasin
RIT1 Ras-like without CAAX 1
RNF167 ring finger protein 167
RUNX3 runt-related transcription factor 3
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SERINC3 serine incorporator 3
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC22A18 solute carrier family 22, member 18
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLPI secretory leukocyte peptidase inhibitor
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SQSTM1 sequestosome 1
SREBF1 sterol regulatory element binding transcription factor 1
SST somatostatin
STAB1 stabilin 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYT1 synaptotagmin I
TALDO1 transaldolase 1
TFE3 transcription factor binding to IGHM enhancer 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TKT transketolase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM106B transmembrane protein 106B
TMEM2 transmembrane protein 2
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPP1 tripeptidyl peptidase I
TUBA4A tubulin, alpha 4a
TWF2 twinfilin actin binding protein 2
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VEGFA vascular endothelial growth factor A
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZFAND5 zinc finger, AN1-type domain 5

decreased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
ADGRG6 adhesion G protein-coupled receptor G6
ADRB2 adrenoceptor beta 2, surface
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
AUTS2 autism susceptibility candidate 2
BIRC5 baculoviral IAP repeat containing 5
BPHL biphenyl hydrolase-like (serine hydrolase)
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CCL5 chemokine (C-C motif) ligand 5
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNE2 cyclin E2
CDC20 cell division cycle 20
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
DACH1 dachshund family transcription factor 1
DBF4 DBF4 zinc finger
DCN decorin
DDAH1 dimethylarginine dimethylaminohydrolase 1
DEPTOR DEP domain containing MTOR-interacting protein
DHFR dihydrofolate reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPT dermatopontin
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FANCI Fanconi anemia, complementation group I
FBLN1 fibulin 1
FEN1 flap structure-specific endonuclease 1
FHL1 four and a half LIM domains 1
FOXM1 forkhead box M1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GMNN geminin, DNA replication inhibitor
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPM6B glycoprotein M6B
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HAT1 histone acetyltransferase 1
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOMER2 homer scaffolding protein 2
HSPA8 heat shock 70kDa protein 8
IL17RB interleukin 17 receptor B
IL7R interleukin 7 receptor
KCTD12 potassium channel tetramerization domain containing 12
KIAA0101 KIAA0101
KIAA1033 KIAA1033
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
LGALS1 lectin, galactoside-binding, soluble, 1
LMNB1 lamin B1
LMNB2 lamin B2
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARCKSL1 MARCKS-like 1
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MEX3D mex-3 RNA binding family member D
MGP matrix Gla protein
MKI67 marker of proliferation Ki-67
MNS1 meiosis-specific nuclear structural 1
MXRA7 matrix-remodelling associated 7
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYH11 myosin, heavy chain 11, smooth muscle
NBL1 neuroblastoma 1, DAN family BMP antagonist
NBN nibrin
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NFIB nuclear factor I/B
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NREP neuronal regeneration related protein
NUSAP1 nucleolar and spindle associated protein 1
PA2G4 proliferation-associated 2G4, 38kDa
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PBX3 pre-B-cell leukemia homeobox 3
PLAC8 placenta-specific 8
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
PRC1 protein regulator of cytokinesis 1
PRKCA protein kinase C, alpha
PRR15L proline rich 15-like
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RAD51AP1 RAD51 associated protein 1
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RNASEH2A ribonuclease H2, subunit A
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
SAMHD1 SAM domain and HD domain 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP4 secreted frizzled-related protein 4
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SPC25 SPC25, NDC80 kinetochore complex component
SPDEF SAM pointed domain containing ETS transcription factor
SPDL1 spindle apparatus coiled-coil protein 1
SPRY2 sprouty homolog 2 (Drosophila)
STMN1 stathmin 1
SYNM synemin, intermediate filament protein
TARP TCR gamma alternate reading frame protein
TBC1D31 TBC1 domain family, member 31
TK1 thymidine kinase 1, soluble
TMEM194A transmembrane protein 194A
TMPO thymopoietin
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TPSAB1 tryptase alpha/beta 1
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
VDAC1 voltage-dependent anion channel 1
ZBTB18 zinc finger and BTB domain containing 18
ZWILCH zwilch kinetochore protein
ZWINT ZW10 interacting kinetochore protein
Funding