BRD-A24396574_celastrol_SKBR3_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-A24396574_celastrol_SKBR3_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ARID4B AT rich interactive domain 4B (RBP1-like)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BIN1 bridging integrator 1
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C8ORF4 chromosome 8 open reading frame 4
CALCOCO2 calcium binding and coiled-coil domain 2
CASP7 caspase 7, apoptosis-related cysteine peptidase
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DEFA5 defensin, alpha 5, Paneth cell-specific
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EPHB2 EPH receptor B2
GDF15 growth differentiation factor 15
H1F0 H1 histone family, member 0
HBD hemoglobin, delta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IFITM1 interferon induced transmembrane protein 1
IRS2 insulin receptor substrate 2
JMJD6 jumonji domain containing 6
KLF4 Kruppel-like factor 4 (gut)
LIMCH1 LIM and calponin homology domains 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MERTK MER proto-oncogene, tyrosine kinase
MMP12 matrix metallopeptidase 12
MMP3 matrix metallopeptidase 3
MTUS1 microtubule associated tumor suppressor 1
NFIL3 nuclear factor, interleukin 3 regulated
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRIP1 nuclear receptor interacting protein 1
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PLA2G16 phospholipase A2, group XVI
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PMEPA1 prostate transmembrane protein, androgen induced 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
REG1A regenerating islet-derived 1 alpha
RHOB ras homolog family member B
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STC2 stanniocalcin 2
TARS threonyl-tRNA synthetase
TBC1D4 TBC1 domain family, member 4
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TSC22D3 TSC22 domain family, member 3

decreased expression

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKAP1 A kinase (PRKA) anchor protein 1
ANOS1 anosmin 1
BEX1 brain expressed, X-linked 1
CAMP cathelicidin antimicrobial peptide
CCL2 chemokine (C-C motif) ligand 2
CCNE2 cyclin E2
CDC20 cell division cycle 20
CES1 carboxylesterase 1
CHGB chromogranin B
COL4A5 collagen, type IV, alpha 5
CPNE3 copine III
CX3CL1 chemokine (C-X3-C motif) ligand 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF5 eukaryotic translation initiation factor 5
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H4C histone cluster 1, H4c
HOXB2 homeobox B2
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
INA internexin neuronal intermediate filament protein, alpha
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KRT5 keratin 5, type II
LAMP5 lysosomal-associated membrane protein family, member 5
LRRC17 leucine rich repeat containing 17
LYZ lysozyme
MATN2 matrilin 2
MEIS1 Meis homeobox 1
MLPH melanophilin
MSMB microseminoprotein, beta-
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
ORM1 orosomucoid 1
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PODXL podocalyxin-like
PROM1 prominin 1
PTGIS prostaglandin I2 (prostacyclin) synthase
RGS4 regulator of G-protein signaling 4
SCG2 secretogranin II
SFRP1 secreted frizzled-related protein 1
SNAP25 synaptosomal-associated protein, 25kDa
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SRPX sushi-repeat containing protein, X-linked
TACSTD2 tumor-associated calcium signal transducer 2
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TUBA1A tubulin, alpha 1a
VSNL1 visinin-like 1
Funding