BRD-A25687296_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

248 genes differentially expressed following the BRD-A25687296_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKAP8L A kinase (PRKA) anchor protein 8-like
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCL3 B-cell CLL/lymphoma 3
BST2 bone marrow stromal cell antigen 2
C4BPA complement component 4 binding protein, alpha
C8ORF4 chromosome 8 open reading frame 4
CADM1 cell adhesion molecule 1
CCDC130 coiled-coil domain containing 130
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLK4 CDC-like kinase 4
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DLX2 distal-less homeobox 2
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP6 dual specificity phosphatase 6
EFNA1 ephrin-A1
FAM13A family with sequence similarity 13, member A
FGG fibrinogen gamma chain
FLRT3 fibronectin leucine rich transmembrane protein 3
FNBP4 formin binding protein 4
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GATA2 GATA binding protein 2
GEM GTP binding protein overexpressed in skeletal muscle
GSE1 Gse1 coiled-coil protein
H2BFS H2B histone family, member S (pseudogene)
H3F3B H3 histone, family 3B (H3.3B)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST2H2BE histone cluster 2, H2be
ICAM1 intercellular adhesion molecule 1
ICAM2 intercellular adhesion molecule 2
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
ILK integrin-linked kinase
ING3 inhibitor of growth family, member 3
IRF1 interferon regulatory factor 1
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM6A lysine (K)-specific demethylase 6A
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT7 keratin 7, type II
KYNU kynureninase
LGALS1 lectin, galactoside-binding, soluble, 1
LIMCH1 LIM and calponin homology domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha)
MGLL monoglyceride lipase
MICU2 mitochondrial calcium uptake 2
MYH10 myosin, heavy chain 10, non-muscle
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NISCH nischarin
NR4A3 nuclear receptor subfamily 4, group A, member 3
OBSL1 obscurin-like 1
PCGF1 polycomb group ring finger 1
PELI1 pellino E3 ubiquitin protein ligase 1
PHIP pleckstrin homology domain interacting protein
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PSPC1 paraspeckle component 1
PTBP2 polypyrimidine tract binding protein 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOB ras homolog family member B
RNFT1 ring finger protein, transmembrane 1
RSRC2 arginine/serine-rich coiled-coil 2
RUNX3 runt-related transcription factor 3
SAMD4A sterile alpha motif domain containing 4A
SDC4 syndecan 4
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SFTPC surfactant protein C
SFTPD surfactant protein D
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMIM7 small integral membrane protein 7
SREK1 splicing regulatory glutamine/lysine-rich protein 1
SRSF7 serine/arginine-rich splicing factor 7
SYNGR3 synaptogyrin 3
TBX2 T-box 2
THUMPD2 THUMP domain containing 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNIK TRAF2 and NCK interacting kinase
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
YPEL5 yippee-like 5 (Drosophila)
ZCCHC8 zinc finger, CCHC domain containing 8
ZFP36 ZFP36 ring finger protein
ZMYM2 zinc finger, MYM-type 2
ZNF140 zinc finger protein 140

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ADIRF adipogenesis regulatory factor
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
ANXA11 annexin A11
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
B3GNT1
BASP1 brain abundant, membrane attached signal protein 1
BLCAP bladder cancer associated protein
CA12 carbonic anhydrase XII
CCDC86 coiled-coil domain containing 86
CD14 CD14 molecule
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CLIC4 chloride intracellular channel 4
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
CTSB cathepsin B
CTSZ cathepsin Z
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3
DHCR7 7-dehydrocholesterol reductase
DPYSL2 dihydropyrimidinase-like 2
DSP desmoplakin
EBP emopamil binding protein (sterol isomerase)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENDOD1 endonuclease domain containing 1
FABP1 fatty acid binding protein 1, liver
FAM20B family with sequence similarity 20, member B
FCGBP Fc fragment of IgG binding protein
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FEN1 flap structure-specific endonuclease 1
FOLR1 folate receptor 1 (adult)
FPR1 formyl peptide receptor 1
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGB3 high mobility group box 3
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IGF1R insulin-like growth factor 1 receptor
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
ITGA6 integrin, alpha 6
KCTD12 potassium channel tetramerization domain containing 12
KDM5D lysine (K)-specific demethylase 5D
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KIAA0232 KIAA0232
KRT5 keratin 5, type II
LEF1 lymphoid enhancer-binding factor 1
LIPA lipase A, lysosomal acid, cholesterol esterase
LMO2 LIM domain only 2 (rhombotin-like 1)
LTBP1 latent transforming growth factor beta binding protein 1
LYZ lysozyme
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MAT2A methionine adenosyltransferase II, alpha
MFAP5 microfibrillar associated protein 5
MGAM maltase-glucoamylase
MLEC malectin
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MNDA myeloid cell nuclear differentiation antigen
MPZL1 myelin protein zero-like 1
MSMO1 methylsterol monooxygenase 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
OLFM4 olfactomedin 4
OLFML3 olfactomedin-like 3
PEBP1 phosphatidylethanolamine binding protein 1
PGK1 phosphoglycerate kinase 1
PI3 peptidase inhibitor 3, skin-derived
PLA2G12A phospholipase A2, group XIIA
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PNO1 partner of NOB1 homolog (S. cerevisiae)
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PSRC1 proline/serine-rich coiled-coil 1
PTGIS prostaglandin I2 (prostacyclin) synthase
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RNASET2 ribonuclease T2
RPS11 ribosomal protein S11
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCML1 sex comb on midleg-like 1 (Drosophila)
SERINC5 serine incorporator 5
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMCO4 single-pass membrane protein with coiled-coil domains 4
SNN stannin
SQLE squalene epoxidase
SRPX sushi-repeat containing protein, X-linked
STMN1 stathmin 1
SYNM synemin, intermediate filament protein
TACC1 transforming, acidic coiled-coil containing protein 1
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TBC1D16 TBC1 domain family, member 16
TFDP1 transcription factor Dp-1
TMEM230 transmembrane protein 230
TMEM47 transmembrane protein 47
TMEM97 transmembrane protein 97
TPBG trophoblast glycoprotein
TPD52L1 tumor protein D52-like 1
TUBB tubulin, beta class I
TUBB6 tubulin, beta 6 class V
TWIST1 twist family bHLH transcription factor 1
TYMS thymidylate synthetase
WSB2 WD repeat and SOCS box containing 2
YBX3 Y box binding protein 3
Funding