BRD-A28105619_curcubitacin I_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

102 genes differentially expressed following the BRD-A28105619_curcubitacin I_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
BGN biglycan
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
COL8A2 collagen, type VIII, alpha 2
CTH cystathionine gamma-lyase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ETV5 ets variant 5
FOXO4 forkhead box O4
GAGE3 G antigen 3
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GLUL glutamate-ammonia ligase
GPM6B glycoprotein M6B
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
KCMF1 potassium channel modulatory factor 1
KLHL21 kelch-like family member 21
MAN1A1 mannosidase, alpha, class 1A, member 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MT1M metallothionein 1M
NELL2 NEL-like 2 (chicken)
NFE2L1 nuclear factor, erythroid 2-like 1
NRCAM neuronal cell adhesion molecule
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PIR pirin (iron-binding nuclear protein)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSAT1 phosphoserine aminotransferase 1
RB1CC1 RB1-inducible coiled-coil 1
SEC14L1 SEC14-like 1 (S. cerevisiae)
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPRED2 sprouty-related, EVH1 domain containing 2
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
STK38L serine/threonine kinase 38 like
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
C3 complement component 3
CCL19 chemokine (C-C motif) ligand 19
CCND2 cyclin D2
CCNE2 cyclin E2
CD47 CD47 molecule
CIRBP cold inducible RNA binding protein
CYR61 cysteine-rich, angiogenic inducer, 61
CYTH1 cytohesin 1
DPYSL3 dihydropyrimidinase-like 3
EDN1 endothelin 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F3 coagulation factor III (thromboplastin, tissue factor)
FEN1 flap structure-specific endonuclease 1
FST follistatin
GADD45B growth arrest and DNA-damage-inducible, beta
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPX1 glutathione peroxidase 1
HOXA10 homeobox A10
HOXA5 homeobox A5
IER3 immediate early response 3
IL33 interleukin 33
JUN jun proto-oncogene
KRT7 keratin 7, type II
MARCKSL1 MARCKS-like 1
MCM2 minichromosome maintenance complex component 2
MCM6 minichromosome maintenance complex component 6
NDN necdin, melanoma antigen (MAGE) family member
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOLC1 nucleolar and coiled-body phosphoprotein 1
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PXDN peroxidasin
SEC23A Sec23 homolog A (S. cerevisiae)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SOX4 SRY (sex determining region Y)-box 4
SRPX sushi-repeat containing protein, X-linked
SRSF7 serine/arginine-rich splicing factor 7
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
UBE2E1 ubiquitin-conjugating enzyme E2E 1
VCAN versican
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