BRD-A28105619_curcubitacin I_NOMO1_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

248 genes differentially expressed following the BRD-A28105619_curcubitacin I_NOMO1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABHD4 abhydrolase domain containing 4
ADAM17 ADAM metallopeptidase domain 17
ADM adrenomedullin
AGFG1 ArfGAP with FG repeats 1
AKAP12 A kinase (PRKA) anchor protein 12
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AUTS2 autism susceptibility candidate 2
AVPI1 arginine vasopressin-induced 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG2 BCL2-associated athanogene 2
BAG3 BCL2-associated athanogene 3
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
C3ORF14 chromosome 3 open reading frame 14
C6ORF62 chromosome 6 open reading frame 62
CAB39 calcium binding protein 39
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CLEC5A C-type lectin domain family 5, member A
CLIC4 chloride intracellular channel 4
COL10A1 collagen, type X, alpha 1
COL5A2 collagen, type V, alpha 2
CREM cAMP responsive element modulator
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CSNK1A1 casein kinase 1, alpha 1
CSRNP2 cysteine-serine-rich nuclear protein 2
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DMTF1 cyclin D binding myb-like transcription factor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DOCK4 dedicator of cytokinesis 4
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EIF5 eukaryotic translation initiation factor 5
FERMT2 fermitin family member 2
FHL2 four and a half LIM domains 2
FOXO3 forkhead box O3
FTH1 ferritin, heavy polypeptide 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GATA3 GATA binding protein 3
GATA6 GATA binding protein 6
GCH1 GTP cyclohydrolase 1
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GLRX2 glutaredoxin 2
GMFB glia maturation factor, beta
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
H2BFS H2B histone family, member S (pseudogene)
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HOXC6 homeobox C6
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IRF7 interferon regulatory factor 7
ISG20 interferon stimulated exonuclease gene 20kDa
ITGAV integrin, alpha V
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM5A lysine (K)-specific demethylase 5A
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KRT81 keratin 81, type II
KYNU kynureninase
LDLR low density lipoprotein receptor
LHFPL2 lipoma HMGIC fusion partner-like 2
LMO3 LIM domain only 3 (rhombotin-like 2)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARS methionyl-tRNA synthetase
MEF2C myocyte enhancer factor 2C
MIR22HG MIR22 host gene
MKNK2 MAP kinase interacting serine/threonine kinase 2
MT1F metallothionein 1F
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NAMPT nicotinamide phosphoribosyltransferase
NEBL nebulette
NFIL3 nuclear factor, interleukin 3 regulated
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9
PCDH9 protocadherin 9
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PHIP pleckstrin homology domain interacting protein
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G16 phospholipase A2, group XVI
PLIN2 perilipin 2
PLS3 plastin 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMP22 peripheral myelin protein 22
POPDC3 popeye domain containing 3
PPARG peroxisome proliferator-activated receptor gamma
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RB1CC1 RB1-inducible coiled-coil 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RND3 Rho family GTPase 3
RSRC2 arginine/serine-rich coiled-coil 2
RYBP RING1 and YY1 binding protein
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SH3GLB1 SH3-domain GRB2-like endophilin B1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPAG9 sperm associated antigen 9
SQSTM1 sequestosome 1
SRP19 signal recognition particle 19kDa
STK17A serine/threonine kinase 17a
STK38L serine/threonine kinase 38 like
STX1A syntaxin 1A (brain)
SULF1 sulfatase 1
TARS threonyl-tRNA synthetase
TDP2 tyrosyl-DNA phosphodiesterase 2
TES testin LIM domain protein
TFE3 transcription factor binding to IGHM enhancer 3
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPD52 tumor protein D52
TREM1 triggering receptor expressed on myeloid cells 1
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TXNRD1 thioredoxin reductase 1
UBAP1 ubiquitin associated protein 1
UBE2B ubiquitin-conjugating enzyme E2B
UFM1 ubiquitin-fold modifier 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WBP5 WW domain binding protein 5
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YPEL5 yippee-like 5 (Drosophila)
ZC3H15 zinc finger CCCH-type containing 15
ZNF410 zinc finger protein 410

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ADCY3 adenylate cyclase 3
ADCY9 adenylate cyclase 9
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANXA4 annexin A4
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BCL2 B-cell CLL/lymphoma 2
BDH1 3-hydroxybutyrate dehydrogenase, type 1
CA12 carbonic anhydrase XII
CBR1 carbonyl reductase 1
CCL2 chemokine (C-C motif) ligand 2
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CES1 carboxylesterase 1
CST3 cystatin C
CTSS cathepsin S
CYBA cytochrome b-245, alpha polypeptide
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DEFB1 defensin, beta 1
ERLIN2 ER lipid raft associated 2
FGFR3 fibroblast growth factor receptor 3
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FUCA1 fucosidase, alpha-L- 1, tissue
FXYD2 FXYD domain containing ion transport regulator 2
GPX2 glutathione peroxidase 2
GPX3 glutathione peroxidase 3
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLF hepatic leukemia factor
HOXA10 homeobox A10
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFRD2 interferon-related developmental regulator 2
IGFBP7 insulin-like growth factor binding protein 7
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JADE2 jade family PHD finger 2
KIAA0930 KIAA0930
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRT14 keratin 14, type I
LEPR leptin receptor
LYZ lysozyme
MCM3 minichromosome maintenance complex component 3
METTL7A methyltransferase like 7A
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTSS1 metastasis suppressor 1
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCBP MYC binding protein
NUP85 nucleoporin 85kDa
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
PCNA proliferating cell nuclear antigen
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PYCARD PYD and CARD domain containing
RAB40B RAB40B, member RAS oncogene family
RCAN2 regulator of calcineurin 2
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RGS5 regulator of G-protein signaling 5
RPIA ribose 5-phosphate isomerase A
SACS sacsin molecular chaperone
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SRM spermidine synthase
SYNGR1 synaptogyrin 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS3 tensin 3
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TXNIP thioredoxin interacting protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZIC1 Zic family member 1
Funding