BRD-A28970875_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

201 genes differentially expressed following the BRD-A28970875_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANO1 anoctamin 1, calcium activated chloride channel
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BHLHE41 basic helix-loop-helix family, member e41
BIRC2 baculoviral IAP repeat containing 2
BRAP BRCA1 associated protein
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
CA2 carbonic anhydrase II
CARS cysteinyl-tRNA synthetase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK17 cyclin-dependent kinase 17
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLU clusterin
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DTNA dystrobrevin, alpha
EFNA1 ephrin-A1
EGR1 early growth response 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF5 eukaryotic translation initiation factor 5
FBN2 fibrillin 2
FHL2 four and a half LIM domains 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM1 intercellular adhesion molecule 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGKV4-1 immunoglobulin kappa variable 4-1
INHBE inhibin, beta E
IQCG IQ motif containing G
IRF1 interferon regulatory factor 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KIAA0226L KIAA0226-like
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
LARP6 La ribonucleoprotein domain family, member 6
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LRRC49 leucine rich repeat containing 49
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP7 microtubule-associated protein 7
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
MSX1 msh homeobox 1
MT1E metallothionein 1E
MT1M metallothionein 1M
NAMPT nicotinamide phosphoribosyltransferase
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRIP1 nuclear receptor interacting protein 1
OSER1 oxidative stress responsive serine-rich 1
PDE4DIP phosphodiesterase 4D interacting protein
PELI2 pellino E3 ubiquitin protein ligase family member 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PON3 paraoxonase 3
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAP prosaposin
PSAT1 phosphoserine aminotransferase 1
PTX3 pentraxin 3, long
PYCR1 pyrroline-5-carboxylate reductase 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RIPK2 receptor-interacting serine-threonine kinase 2
RLF rearranged L-myc fusion
RNMT RNA (guanine-7-) methyltransferase
RSL1D1 ribosomal L1 domain containing 1
RSRC2 arginine/serine-rich coiled-coil 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCRG1 stimulator of chondrogenesis 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SOD2 superoxide dismutase 2, mitochondrial
SPAG9 sperm associated antigen 9
STC2 stanniocalcin 2
STK38L serine/threonine kinase 38 like
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIP1 TNFAIP3 interacting protein 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNL4B thioredoxin-like 4B
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
ZBTB10 zinc finger and BTB domain containing 10
ZFAND5 zinc finger, AN1-type domain 5

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASPH aspartate beta-hydroxylase
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF5 activating transcription factor 5
AURKA aurora kinase A
B3GNT1
BASP1 brain abundant, membrane attached signal protein 1
BIRC5 baculoviral IAP repeat containing 5
CBR1 carbonyl reductase 1
CCNA2 cyclin A2
CCNB1 cyclin B1
CCND1 cyclin D1
CCNF cyclin F
CD58 CD58 molecule
CDC25B cell division cycle 25B
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
COL4A2 collagen, type IV, alpha 2
CYTL1 cytokine-like 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DHRS1 dehydrogenase/reductase (SDR family) member 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DUSP4 dual specificity phosphatase 4
ENDOD1 endonuclease domain containing 1
FABP4 fatty acid binding protein 4, adipocyte
FAM57A family with sequence similarity 57, member A
FOXA1 forkhead box A1
HACD1 3-hydroxyacyl-CoA dehydratase 1
HMGB3 high mobility group box 3
HN1 hematological and neurological expressed 1
HOXA10 homeobox A10
HOXA5 homeobox A5
HYAL2 hyaluronoglucosaminidase 2
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
ICMT isoprenylcysteine carboxyl methyltransferase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
KANK1 KN motif and ankyrin repeat domains 1
KANK2 KN motif and ankyrin repeat domains 2
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
LAMC1 laminin, gamma 1 (formerly LAMB2)
LBR lamin B receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPCAT4 lysophosphatidylcholine acyltransferase 4
MCAM melanoma cell adhesion molecule
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MRPL17 mitochondrial ribosomal protein L17
NFIB nuclear factor I/B
NMU neuromedin U
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F6 nuclear receptor subfamily 2, group F, member 6
PDCD2 programmed cell death 2
PEG10 paternally expressed 10
PLK1 polo-like kinase 1
PLN phospholamban
PNMA1 paraneoplastic Ma antigen 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCD protein kinase C, delta
PRMT2 protein arginine methyltransferase 2
PRSS23 protease, serine, 23
PSCA prostate stem cell antigen
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SMS spermine synthase
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STOM stomatin
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1
TMEM223 transmembrane protein 223
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TRIM14 tripartite motif containing 14
TUBB6 tubulin, beta 6 class V
VCAN versican
WWTR1 WW domain containing transcription regulator 1
ZCCHC24 zinc finger, CCHC domain containing 24
Funding