BRD-A30437061_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

162 genes differentially expressed following the BRD-A30437061_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDOC aldolase C, fructose-bisphosphate
ANPEP alanyl (membrane) aminopeptidase
AQP1 aquaporin 1 (Colton blood group)
ATF3 activating transcription factor 3
BAMBI BMP and activin membrane-bound inhibitor
BTG2 BTG family, member 2
C5AR1 complement component 5a receptor 1
C7 complement component 7
CA1 carbonic anhydrase I
CCL2 chemokine (C-C motif) ligand 2
CD14 CD14 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKB creatine kinase, brain
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL3A1 collagen, type III, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CTGF connective tissue growth factor
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DPYSL3 dihydropyrimidinase-like 3
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FBLN1 fibulin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA2 GATA binding protein 2
GSN gelsolin
H3F3B H3 histone, family 3B (H3.3B)
HBB hemoglobin, beta
HBD hemoglobin, delta
HES1 hes family bHLH transcription factor 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
ISG15 ISG15 ubiquitin-like modifier
JUNB jun B proto-oncogene
KIAA0226L KIAA0226-like
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KRT19 keratin 19, type I
KRT8 keratin 8, type II
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAOB monoamine oxidase B
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
MX1 MX dynamin-like GTPase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POSTN periostin, osteoblast specific factor
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RNASE4 ribonuclease, RNase A family, 4
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG2 secretogranin II
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLPI secretory leukocyte peptidase inhibitor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
VSNL1 visinin-like 1
VTCN1 V-set domain containing T cell activation inhibitor 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADNP activity-dependent neuroprotector homeobox
AFF1 AF4/FMR2 family, member 1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARID4B AT rich interactive domain 4B (RBP1-like)
BMI1 BMI1 proto-oncogene, polycomb ring finger
C2CD5 C2 calcium-dependent domain containing 5
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CHD7 chromodomain helicase DNA binding protein 7
CNOT4 CCR4-NOT transcription complex, subunit 4
COIL coilin
CRK v-crk avian sarcoma virus CT10 oncogene homolog
DUSP4 dual specificity phosphatase 4
FAM208B family with sequence similarity 208, member B
FOXJ3 forkhead box J3
GOLGA8A golgin A8 family, member A
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JADE1 jade family PHD finger 1
JARID2 jumonji, AT rich interactive domain 2
JMJD6 jumonji domain containing 6
KAT6A K(lysine) acetyltransferase 6A
KDM2A lysine (K)-specific demethylase 2A
KEAP1 kelch-like ECH-associated protein 1
KYNU kynureninase
LIMCH1 LIM and calponin homology domains 1
LIPT1 lipoyltransferase 1
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MED13 mediator complex subunit 13
MTF2 metal response element binding transcription factor 2
NET1 neuroepithelial cell transforming 1
NOTCH2NL notch 2 N-terminal like
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRRC2C proline-rich coiled-coil 2C
PTHLH parathyroid hormone-like hormone
PUM1 pumilio RNA-binding family member 1
RANBP2 RAN binding protein 2
RBM47 RNA binding motif protein 47
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RNF4 ring finger protein 4
RNMT RNA (guanine-7-) methyltransferase
RREB1 ras responsive element binding protein 1
S100A7 S100 calcium binding protein A7
SCAF8 SR-related CTD-associated factor 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TBP TATA box binding protein
TBPL1 TBP-like 1
TFF1 trefoil factor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM2 transmembrane protein 2
TMEM97 transmembrane protein 97
TP53BP2 tumor protein p53 binding protein 2
TRIM33 tripartite motif containing 33
TSC22D2 TSC22 domain family, member 2
TSPYL5 TSPY-like 5
U2SURP U2 snRNP-associated SURP domain containing
USP1 ubiquitin specific peptidase 1
ZC3H4 zinc finger CCCH-type containing 4
ZNF22 zinc finger protein 22