BRD-A30437061_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

157 genes differentially expressed following the BRD-A30437061_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AHNAK2 AHNAK nucleoprotein 2
AIDA axin interactor, dorsalization associated
ALDOC aldolase C, fructose-bisphosphate
APLP2 amyloid beta (A4) precursor-like protein 2
ATF3 activating transcription factor 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
BEX4 brain expressed, X-linked 4
CALD1 caldesmon 1
CAPG capping protein (actin filament), gelsolin-like
CD14 CD14 molecule
CD38 CD38 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CECR1 cat eye syndrome chromosome region, candidate 1
CES1 carboxylesterase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL11A1 collagen, type XI, alpha 1
COL3A1 collagen, type III, alpha 1
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
CTSK cathepsin K
CXCL13 chemokine (C-X-C motif) ligand 13
CYBB cytochrome b-245, beta polypeptide
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
ECHDC3 enoyl CoA hydratase domain containing 3
EGR2 early growth response 2
FBLN1 fibulin 1
FZD6 frizzled class receptor 6
G0S2 G0/G1 switch 2
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
HBB hemoglobin, beta
IDO1 indoleamine 2,3-dioxygenase 1
IFITM1 interferon induced transmembrane protein 1
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LUM lumican
LY96 lymphocyte antigen 96
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
MME membrane metallo-endopeptidase
MOSPD1 motile sperm domain containing 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
PBX3 pre-B-cell leukemia homeobox 3
PERP PERP, TP53 apoptosis effector
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRAME preferentially expressed antigen in melanoma
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
SCPEP1 serine carboxypeptidase 1
SDC2 syndecan 2
SFN stratifin
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SORD sorbitol dehydrogenase
STK26 serine/threonine protein kinase 26
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52 tumor protein D52
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
VIM vimentin
VTCN1 V-set domain containing T cell activation inhibitor 1
WISP2 WNT1 inducible signaling pathway protein 2
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ADNP activity-dependent neuroprotector homeobox
ARGLU1 arginine and glutamate rich 1
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
CA2 carbonic anhydrase II
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CD58 CD58 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDK7 cyclin-dependent kinase 7
CENPA centromere protein A
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
DLK1 delta-like 1 homolog (Drosophila)
EED embryonic ectoderm development
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPS8 epidermal growth factor receptor pathway substrate 8
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FHL2 four and a half LIM domains 2
FNBP4 formin binding protein 4
FNDC3B fibronectin type III domain containing 3B
FOXD1 forkhead box D1
FOXJ3 forkhead box J3
FOXO3 forkhead box O3
GRWD1 glutamate-rich WD repeat containing 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HSPA8 heat shock 70kDa protein 8
JMJD6 jumonji domain containing 6
KEAP1 kelch-like ECH-associated protein 1
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MBNL1 muscleblind-like splicing regulator 1
MBNL2 muscleblind-like splicing regulator 2
MED13 mediator complex subunit 13
MGLL monoglyceride lipase
MPRIP myosin phosphatase Rho interacting protein
MTMR2 myotubularin related protein 2
NET1 neuroepithelial cell transforming 1
NOL11 nucleolar protein 11
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PDGFC platelet derived growth factor C
PDS5B PDS5 cohesin associated factor B
PNN pinin, desmosome associated protein
PPARG peroxisome proliferator-activated receptor gamma
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PRRC2C proline-rich coiled-coil 2C
PSPC1 paraspeckle component 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTX3 pentraxin 3, long
QKI QKI, KH domain containing, RNA binding
RBM25 RNA binding motif protein 25
RYBP RING1 and YY1 binding protein
SEC62 SEC62 homolog (S. cerevisiae)
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SRSF5 serine/arginine-rich splicing factor 5
STAR steroidogenic acute regulatory protein
SUZ12 SUZ12 polycomb repressive complex 2 subunit
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFF1 trefoil factor 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLE4 transducin-like enhancer of split 4
TRIM33 tripartite motif containing 33
TSC22D2 TSC22 domain family, member 2
UBE3A ubiquitin protein ligase E3A
USP22 ubiquitin specific peptidase 22
USP3 ubiquitin specific peptidase 3
WAC WW domain containing adaptor with coiled-coil
WIPF2 WAS/WASL interacting protein family, member 2
YTHDC1 YTH domain containing 1
ZCCHC8 zinc finger, CCHC domain containing 8
ZMYM2 zinc finger, MYM-type 2
Funding