BRD-A34205397_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

144 genes differentially expressed following the BRD-A34205397_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARID4B AT rich interactive domain 4B (RBP1-like)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BCL3 B-cell CLL/lymphoma 3
BMP2 bone morphogenetic protein 2
BTG2 BTG family, member 2
C8ORF4 chromosome 8 open reading frame 4
CADM1 cell adhesion molecule 1
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCNL1 cyclin L1
CD4 CD4 molecule
CEMIP cell migration inducing protein, hyaluronan binding
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F3 coagulation factor III (thromboplastin, tissue factor)
FAM69A family with sequence similarity 69, member A
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FXYD6 FXYD domain containing ion transport regulator 6
GADD45A growth arrest and DNA-damage-inducible, alpha
GEM GTP binding protein overexpressed in skeletal muscle
GGT1 gamma-glutamyltransferase 1
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST1H2BK histone cluster 1, H2bk
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IL32 interleukin 32
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KIAA0226L KIAA0226-like
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
LOC100505650 uncharacterized LOC100505650
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MCL1 myeloid cell leukemia 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MT1F metallothionein 1F
MT1M metallothionein 1M
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
OLFML2A olfactomedin-like 2A
P3H2 prolyl 3-hydroxylase 2
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRSS21 protease, serine, 21 (testisin)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RND1 Rho family GTPase 1
SAMD4A sterile alpha motif domain containing 4A
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
SOCS3 suppressor of cytokine signaling 3
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SPRED2 sprouty-related, EVH1 domain containing 2
TBX3 T-box 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIB1 tribbles pseudokinase 1
TSC22D1 TSC22 domain family, member 1
VEGFA vascular endothelial growth factor A
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOD apolipoprotein D
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
C2CD5 C2 calcium-dependent domain containing 5
CAPN2 calpain 2, (m/II) large subunit
CCND1 cyclin D1
CD59 CD59 molecule, complement regulatory protein
CDC20 cell division cycle 20
CLU clusterin
COCH cochlin
DEFB1 defensin, beta 1
ECI2 enoyl-CoA delta isomerase 2
FLNB filamin B, beta
FSTL1 follistatin-like 1
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HOXC6 homeobox C6
IGFBP7 insulin-like growth factor binding protein 7
IGLL1 immunoglobulin lambda-like polypeptide 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KANK2 KN motif and ankyrin repeat domains 2
LAMB1 laminin, beta 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MXRA7 matrix-remodelling associated 7
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR2F6 nuclear receptor subfamily 2, group F, member 6
PFN2 profilin 2
PRSS23 protease, serine, 23
PTGIS prostaglandin I2 (prostacyclin) synthase
RBP1 retinol binding protein 1, cellular
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM2 ribonucleotide reductase M2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
STK39 serine threonine kinase 39
TBC1D16 TBC1 domain family, member 16
THAP11 THAP domain containing 11
TSPAN13 tetraspanin 13
VPREB1 pre-B lymphocyte 1