BRD-A34806832_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

238 genes differentially expressed following the BRD-A34806832_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADM adrenomedullin
AEBP1 AE binding protein 1
ANKRD11 ankyrin repeat domain 11
ANXA1 annexin A1
APOLD1 apolipoprotein L domain containing 1
ARG1 arginase 1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASPN asporin
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AZU1 azurocidin 1
BRD2 bromodomain containing 2
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CFH complement factor H
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKS2 CDC28 protein kinase regulatory subunit 2
CLC Charcot-Leyden crystal galectin
CNPY3 canopy FGF signaling regulator 3
COL11A1 collagen, type XI, alpha 1
COL14A1 collagen, type XIV, alpha 1
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CTSB cathepsin B
CTSV cathepsin V
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DLC1 DLC1 Rho GTPase activating protein
DMTF1 cyclin D binding myb-like transcription factor 1
DUSP1 dual specificity phosphatase 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGR1 early growth response 1
EGR3 early growth response 3
EIF1 eukaryotic translation initiation factor 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF4A1 eukaryotic translation initiation factor 4A1
ELANE elastase, neutrophil expressed
EMP1 epithelial membrane protein 1
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM117A family with sequence similarity 117, member A
FKBP14 FK506 binding protein 14, 22 kDa
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FST follistatin
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45B growth arrest and DNA-damage-inducible, beta
GAS6 growth arrest-specific 6
GATA6 GATA binding protein 6
GLS glutaminase
GSTM3 glutathione S-transferase mu 3 (brain)
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KDM6B lysine (K)-specific demethylase 6B
KIAA0226L KIAA0226-like
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KLK5 kallikrein-related peptidase 5
LAMP5 lysosomal-associated membrane protein family, member 5
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP7 microtubule-associated protein 7
MCL1 myeloid cell leukemia 1
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MIR22HG MIR22 host gene
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
NDRG1 N-myc downstream regulated 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPL1 nucleoporin like 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PEG3 paternally expressed 3
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLA2G15 phospholipase A2, group XV
PLAGL1 pleiomorphic adenoma gene-like 1
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPIF peptidylprolyl isomerase F
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRSS21 protease, serine, 21 (testisin)
PTBP2 polypyrimidine tract binding protein 2
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RIOK3 RIO kinase 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD5 stearoyl-CoA desaturase 5
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SPAG9 sperm associated antigen 9
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRSF10 serine/arginine-rich splicing factor 10
SRSF5 serine/arginine-rich splicing factor 5
SRSF7 serine/arginine-rich splicing factor 7
STOM stomatin
SWAP70 SWAP switching B-cell complex 70kDa subunit
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TFRC transferrin receptor
THBS2 thrombospondin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE4 transducin-like enhancer of split 4
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TP53BP2 tumor protein p53 binding protein 2
TRA2B transformer 2 beta homolog (Drosophila)
TSC22D2 TSC22 domain family, member 2
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
UGCG UDP-glucose ceramide glucosyltransferase
VNN1 vanin 1
XIST X inactive specific transcript (non-protein coding)
ZBED2 zinc finger, BED-type containing 2
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AIM1 absent in melanoma 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AMACR alpha-methylacyl-CoA racemase
ANKRD10 ankyrin repeat domain 10
ASXL2 additional sex combs like transcriptional regulator 2
ATMIN ATM interactor
BASP1 brain abundant, membrane attached signal protein 1
BIN1 bridging integrator 1
C3ORF14 chromosome 3 open reading frame 14
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CADPS2 Ca++-dependent secretion activator 2
CANT1 calcium activated nucleotidase 1
CAST calpastatin
CAV2 caveolin 2
CBR1 carbonyl reductase 1
CBR3 carbonyl reductase 3
CCL5 chemokine (C-C motif) ligand 5
CCNA2 cyclin A2
CCNF cyclin F
CDC25B cell division cycle 25B
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CENPA centromere protein A
CFB complement factor B
CHL1 cell adhesion molecule L1-like
CXCL6 chemokine (C-X-C motif) ligand 6
DCLK1 doublecortin-like kinase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DIXDC1 DIX domain containing 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPYSL2 dihydropyrimidinase-like 2
DUSP4 dual specificity phosphatase 4
ERI2 ERI1 exoribonuclease family member 2
FAM129A family with sequence similarity 129, member A
FAM134B family with sequence similarity 134, member B
FAM178A family with sequence similarity 178, member A
FANCF Fanconi anemia, complementation group F
GDF15 growth differentiation factor 15
GIMAP6 GTPase, IMAP family member 6
GNLY granulysin
GPM6B glycoprotein M6B
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IDO1 indoleamine 2,3-dioxygenase 1
JADE2 jade family PHD finger 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDM5D lysine (K)-specific demethylase 5D
KEAP1 kelch-like ECH-associated protein 1
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPAR1 lysophosphatidic acid receptor 1
MAGED1 melanoma antigen family D1
MEOX1 mesenchyme homeobox 1
MKKS McKusick-Kaufman syndrome
MMP7 matrix metallopeptidase 7
MSMB microseminoprotein, beta-
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
PCSK1 proprotein convertase subtilisin/kexin type 1
PLK1 polo-like kinase 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPARG peroxisome proliferator-activated receptor gamma
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAD51C RAD51 paralog C
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RIN2 Ras and Rab interactor 2
RPS4Y1 ribosomal protein S4, Y-linked 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLAMF1 signaling lymphocytic activation molecule family member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC25A46 solute carrier family 25, member 46
SNX10 sorting nexin 10
SORBS1 sorbin and SH3 domain containing 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STK39 serine threonine kinase 39
SYT1 synaptotagmin I
TBC1D16 TBC1 domain family, member 16
THAP11 THAP domain containing 11
THYN1 thymocyte nuclear protein 1
TIMP4 TIMP metallopeptidase inhibitor 4
TNC tenascin C
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX3 TOX high mobility group box family member 3
TRIB2 tribbles pseudokinase 2
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like
TXNDC9 thioredoxin domain containing 9
WNT5A wingless-type MMTV integration site family, member 5A
ZMYND8 zinc finger, MYND-type containing 8
Funding