BRD-A35588707_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

214 genes differentially expressed following the BRD-A35588707_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACKR3 atypical chemokine receptor 3
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ALOX5 arachidonate 5-lipoxygenase
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAMBI BMP and activin membrane-bound inhibitor
BCL2A1 BCL2-related protein A1
BCL3 B-cell CLL/lymphoma 3
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
BTG2 BTG family, member 2
C7 complement component 7
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD83 CD83 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEMIP cell migration inducing protein, hyaluronan binding
CH25H cholesterol 25-hydroxylase
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CPE carboxypeptidase E
CSF1 colony stimulating factor 1 (macrophage)
CSRP1 cysteine and glycine-rich protein 1
CTGF connective tissue growth factor
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DHCR24 24-dehydrocholesterol reductase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
DUSP14 dual specificity phosphatase 14
DUSP5 dual specificity phosphatase 5
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
FABP4 fatty acid binding protein 4, adipocyte
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
FHL2 four and a half LIM domains 2
FILIP1L filamin A interacting protein 1-like
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO1 forkhead box O1
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GBP1 guanylate binding protein 1, interferon-inducible
GCH1 GTP cyclohydrolase 1
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IL1B interleukin 1, beta
IL32 interleukin 32
IL6 interleukin 6
INHBA inhibin, beta A
INHBB inhibin, beta B
IRF1 interferon regulatory factor 1
JAG1 jagged 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KIF5C kinesin family member 5C
KLF10 Kruppel-like factor 10
KLHL21 kelch-like family member 21
LDLR low density lipoprotein receptor
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIF leukemia inhibitory factor
LIMK2 LIM domain kinase 2
LMO3 LIM domain only 3 (rhombotin-like 2)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MIR22HG MIR22 host gene
MYB v-myb avian myeloblastosis viral oncogene homolog
NDRG1 N-myc downstream regulated 1
NEFL neurofilament, light polypeptide
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NINJ1 ninjurin 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPR1 nuclear protein, transcriptional regulator, 1
PDGFA platelet-derived growth factor alpha polypeptide
PDHX pyruvate dehydrogenase complex, component X
PEG3 paternally expressed 3
PELI1 pellino E3 ubiquitin protein ligase 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
PTX3 pentraxin 3, long
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS1 regulator of G-protein signaling 1
RGS16 regulator of G-protein signaling 16
RHOB ras homolog family member B
RRAD Ras-related associated with diabetes
RSL1D1 ribosomal L1 domain containing 1
SAMD4A sterile alpha motif domain containing 4A
SCUBE2 signal peptide, CUB domain, EGF-like 2
SDC4 syndecan 4
SELE selectin E
SESN1 sestrin 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SOCS1 suppressor of cytokine signaling 1
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SQLE squalene epoxidase
SQSTM1 sequestosome 1
SULF1 sulfatase 1
TAGLN transgelin
TFRC transferrin receptor
TIGAR TP53 induced glycolysis regulatory phosphatase
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TNIP1 TNFAIP3 interacting protein 1
TOB1 transducer of ERBB2, 1
TRIM22 tripartite motif containing 22
TUFT1 tuftelin 1
VCAM1 vascular cell adhesion molecule 1
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein
ZMAT3 zinc finger, matrin-type 3
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
AUTS2 autism susceptibility candidate 2
BIN1 bridging integrator 1
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CENPF centromere protein F, 350/400kDa
CTTN cortactin
DUSP4 dual specificity phosphatase 4
EDNRB endothelin receptor type B
FAM57A family with sequence similarity 57, member A
FOLR1 folate receptor 1 (adult)
FOXJ3 forkhead box J3
FXYD5 FXYD domain containing ion transport regulator 5
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GSTA1 glutathione S-transferase alpha 1
HMGA2 high mobility group AT-hook 2
HOXC10 homeobox C10
HOXC6 homeobox C6
JARID2 jumonji, AT rich interactive domain 2
LBR lamin B receptor
LMNB1 lamin B1
LMO4 LIM domain only 4
MAP1B microtubule-associated protein 1B
MEF2C myocyte enhancer factor 2C
MELK maternal embryonic leucine zipper kinase
MET MET proto-oncogene, receptor tyrosine kinase
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR2F2 nuclear receptor subfamily 2, group F, member 2
PBK PDZ binding kinase
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDAP1 PDGFA associated protein 1
PEBP1 phosphatidylethanolamine binding protein 1
PFN2 profilin 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK1 polo-like kinase 1
PROM1 prominin 1
PRSS23 protease, serine, 23
QPCT glutaminyl-peptide cyclotransferase
RAD23B RAD23 homolog B (S. cerevisiae)
RHOBTB3 Rho-related BTB domain containing 3
S100A7 S100 calcium binding protein A7
SEPT9 septin 9
SFRP1 secreted frizzled-related protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SPRR3 small proline-rich protein 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMEM97 transmembrane protein 97
TOP2A topoisomerase (DNA) II alpha 170kDa
TPD52L1 tumor protein D52-like 1
TUBB tubulin, beta class I
ZMYND8 zinc finger, MYND-type containing 8