BRD-A35588707_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

156 genes differentially expressed following the BRD-A35588707_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD4 abhydrolase domain containing 4
AKR1C3 aldo-keto reductase family 1, member C3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANXA4 annexin A4
BTG2 BTG family, member 2
CADM1 cell adhesion molecule 1
CAPN2 calpain 2, (m/II) large subunit
CAST calpastatin
CD44 CD44 molecule (Indian blood group)
CD52 CD52 molecule
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CSTA cystatin A (stefin A)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DHRS1 dehydrogenase/reductase (SDR family) member 1
ECM1 extracellular matrix protein 1
ENO2 enolase 2 (gamma, neuronal)
EPHA2 EPH receptor A2
FAS Fas cell surface death receptor
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GLS glutaminase
GSTM3 glutathione S-transferase mu 3 (brain)
HLA-B major histocompatibility complex, class I, B
IER5 immediate early response 5
IGKC immunoglobulin kappa constant
KRT13 keratin 13, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
LAMB3 laminin, beta 3
LOXL1 lysyl oxidase-like 1
MAOA monoamine oxidase A
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NT5E 5'-nucleotidase, ecto (CD73)
PDE4DIP phosphodiesterase 4D interacting protein
PDGFA platelet-derived growth factor alpha polypeptide
PERP PERP, TP53 apoptosis effector
PPL periplakin
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGCC regulator of cell cycle
RPS27L ribosomal protein S27-like
S100A2 S100 calcium binding protein A2
SESN1 sestrin 1
SFN stratifin
SPATA20 spermatogenesis associated 20
TIGAR TP53 induced glycolysis regulatory phosphatase
TMEM45A transmembrane protein 45A
TP53TG1 TP53 target 1 (non-protein coding)
TRIM22 tripartite motif containing 22
TRIM29 tripartite motif containing 29
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WDR7 WD repeat domain 7
WNT5A wingless-type MMTV integration site family, member 5A
YBX3 Y box binding protein 3
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
AGR2 anterior gradient 2
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMD1 adenosylmethionine decarboxylase 1
APOD apolipoprotein D
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
AURKA aurora kinase A
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C8ORF4 chromosome 8 open reading frame 4
CA12 carbonic anhydrase XII
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CCNA2 cyclin A2
CCNE2 cyclin E2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDK1 cyclin-dependent kinase 1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CHIC2 cysteine-rich hydrophobic domain 2
CKS2 CDC28 protein kinase regulatory subunit 2
COTL1 coactosin-like F-actin binding protein 1
CXCL12 chemokine (C-X-C motif) ligand 12
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK1 delta-like 1 homolog (Drosophila)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
ELOVL2 ELOVL fatty acid elongase 2
ENOPH1 enolase-phosphatase 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FOLR1 folate receptor 1 (adult)
GATA3 GATA binding protein 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GCH1 GTP cyclohydrolase 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRIA2 glutamate receptor, ionotropic, AMPA 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
JADE2 jade family PHD finger 2
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LIMS1 LIM and senescent cell antigen-like domains 1
LPP LIM domain containing preferred translocation partner in lipoma
LTF lactotransferrin
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MAST2 microtubule associated serine/threonine kinase 2
MBNL1 muscleblind-like splicing regulator 1
MELK maternal embryonic leucine zipper kinase
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MYB v-myb avian myeloblastosis viral oncogene homolog
NEK2 NIMA-related kinase 2
NFIB nuclear factor I/B
NNMT nicotinamide N-methyltransferase
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
PBK PDZ binding kinase
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PLA2G16 phospholipase A2, group XVI
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
QKI QKI, KH domain containing, RNA binding
RAB31 RAB31, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RHOBTB3 Rho-related BTB domain containing 3
S100P S100 calcium binding protein P
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SPDEF SAM pointed domain containing ETS transcription factor
TCF4 transcription factor 4
TFF1 trefoil factor 1
TLE4 transducin-like enhancer of split 4
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TSPAN8 tetraspanin 8
TTK TTK protein kinase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
VCAM1 vascular cell adhesion molecule 1
VCAN versican
WWTR1 WW domain containing transcription regulator 1
Funding