BRD-A36630025_-666_A375_6.0_h_0.35_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

103 genes differentially expressed following the BRD-A36630025_-666_A375_6.0_h_0.35_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
ALOX5 arachidonate 5-lipoxygenase
BTG2 BTG family, member 2
CCL2 chemokine (C-C motif) ligand 2
CD86 CD86 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLC Charcot-Leyden crystal galectin
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
CTSK cathepsin K
CXCL10 chemokine (C-X-C motif) ligand 10
CYCS cytochrome c, somatic
DCN decorin
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
FHL2 four and a half LIM domains 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
GIMAP6 GTPase, IMAP family member 6
ICAM1 intercellular adhesion molecule 1
IL32 interleukin 32
IL6 interleukin 6
JUNB jun B proto-oncogene
KLF10 Kruppel-like factor 10
KLHL21 kelch-like family member 21
LXN latexin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MIR22HG MIR22 host gene
MMP12 matrix metallopeptidase 12
MPO myeloperoxidase
NDRG1 N-myc downstream regulated 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A2 nuclear receptor subfamily 4, group A, member 2
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
RHOB ras homolog family member B
RRAD Ras-related associated with diabetes
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC4 syndecan 4
SESN1 sestrin 1
SFRP4 secreted frizzled-related protein 4
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
TFRC transferrin receptor
TOB1 transducer of ERBB2, 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TUBB2A tubulin, beta 2A class IIa
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ADAM10 ADAM metallopeptidase domain 10
AGTR1 angiotensin II receptor, type 1
AURKA aurora kinase A
CCNA2 cyclin A2
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CENPF centromere protein F, 350/400kDa
CHEK2 checkpoint kinase 2
CIT citron rho-interacting serine/threonine kinase
CSE1L CSE1 chromosome segregation 1-like (yeast)
DARS aspartyl-tRNA synthetase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EHBP1 EH domain binding protein 1
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB3 erb-b2 receptor tyrosine kinase 3
FOXD1 forkhead box D1
GRIA2 glutamate receptor, ionotropic, AMPA 2
IGF1R insulin-like growth factor 1 receptor
ITGA6 integrin, alpha 6
LAMC1 laminin, gamma 1 (formerly LAMB2)
LBR lamin B receptor
MAP1B microtubule-associated protein 1B
MAST2 microtubule associated serine/threonine kinase 2
MBNL1 muscleblind-like splicing regulator 1
MBNL2 muscleblind-like splicing regulator 2
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MPRIP myosin phosphatase Rho interacting protein
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NRIP1 nuclear receptor interacting protein 1
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PDS5A PDS5 cohesin associated factor A
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEKHA5 pleckstrin homology domain containing, family A member 5
PODXL podocalyxin-like
PPARG peroxisome proliferator-activated receptor gamma
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PRSS23 protease, serine, 23
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RREB1 ras responsive element binding protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TBL1X transducin (beta)-like 1X-linked
TOP2A topoisomerase (DNA) II alpha 170kDa
XPO1 exportin 1