BRD-A38030642_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

173 genes differentially expressed following the BRD-A38030642_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APOD apolipoprotein D
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BTG1 B-cell translocation gene 1, anti-proliferative
CAPN2 calpain 2, (m/II) large subunit
CAST calpastatin
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK17 cyclin-dependent kinase 17
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHIC2 cysteine-rich hydrophobic domain 2
CHMP4A charged multivesicular body protein 4A
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ELF1 E74-like factor 1 (ets domain transcription factor)
ELOVL5 ELOVL fatty acid elongase 5
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EREG epiregulin
EZR ezrin
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXG1 forkhead box G1
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GEM GTP binding protein overexpressed in skeletal muscle
GTPBP2 GTP binding protein 2
HBEGF heparin-binding EGF-like growth factor
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
IER2 immediate early response 2
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
INHBA inhibin, beta A
JAG1 jagged 1
JMJD1C jumonji domain containing 1C
JUNB jun B proto-oncogene
KDM6B lysine (K)-specific demethylase 6B
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLHL24 kelch-like family member 24
KRT23 keratin 23, type I
KRT81 keratin 81, type II
LAMC2 laminin, gamma 2
LARP6 La ribonucleoprotein domain family, member 6
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MCL1 myeloid cell leukemia 1
MOCOS molybdenum cofactor sulfurase
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5E 5'-nucleotidase, ecto (CD73)
OLFM4 olfactomedin 4
PALLD palladin, cytoskeletal associated protein
PAWR PRKC, apoptosis, WT1, regulator
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PXDC1 PX domain containing 1
RHOB ras homolog family member B
RIPK2 receptor-interacting serine-threonine kinase 2
RND3 Rho family GTPase 3
S100A6 S100 calcium binding protein A6
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STC2 stanniocalcin 2
SYT1 synaptotagmin I
TIMP1 TIMP metallopeptidase inhibitor 1
TOX3 TOX high mobility group box family member 3
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TXNRD1 thioredoxin reductase 1
VEGFA vascular endothelial growth factor A
ZFP36 ZFP36 ring finger protein
ZNF160 zinc finger protein 160
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ADA adenosine deaminase
AK4 adenylate kinase 4
APP amyloid beta (A4) precursor protein
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
C6ORF62 chromosome 6 open reading frame 62
CA2 carbonic anhydrase II
CD99 CD99 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPA centromere protein A
COL9A3 collagen, type IX, alpha 3
CRIP1 cysteine-rich protein 1 (intestinal)
CTSH cathepsin H
DEFB1 defensin, beta 1
EHD3 EH-domain containing 3
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FLRT3 fibronectin leucine rich transmembrane protein 3
HACD1 3-hydroxyacyl-CoA dehydratase 1
HMGN3 high mobility group nucleosomal binding domain 3
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFITM3 interferon induced transmembrane protein 3
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KIF20A kinesin family member 20A
LAMB1 laminin, beta 1
LOC100505650 uncharacterized LOC100505650
LPCAT1 lysophosphatidylcholine acyltransferase 1
MCAM melanoma cell adhesion molecule
MXRA5 matrix-remodelling associated 5
NREP neuronal regeneration related protein
PDZK1 PDZ domain containing 1
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PODXL podocalyxin-like
POSTN periostin, osteoblast specific factor
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PVALB parvalbumin
RPS11 ribosomal protein S11
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A10 S100 calcium binding protein A10
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TFDP1 transcription factor Dp-1
TMEM243 transmembrane protein 243, mitochondrial
TNNC1 troponin C type 1 (slow)
TUBB tubulin, beta class I
ZC3HAV1 zinc finger CCCH-type, antiviral 1
Funding