BRD-A38030642_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

82 genes differentially expressed following the BRD-A38030642_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
CARS cysteinyl-tRNA synthetase
CD163 CD163 molecule
CFH complement factor H
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL1A1 collagen, type I, alpha 1
CPD carboxypeptidase D
CTSS cathepsin S
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DUSP5 dual specificity phosphatase 5
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
FKBP14 FK506 binding protein 14, 22 kDa
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GPR87 G protein-coupled receptor 87
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IARS isoleucyl-tRNA synthetase
IFRD1 interferon-related developmental regulator 1
KDM7A lysine (K)-specific demethylase 7A
KLF6 Kruppel-like factor 6
LAMB1 laminin, beta 1
LDLR low density lipoprotein receptor
MCL1 myeloid cell leukemia 1
MPZL2 myelin protein zero-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIL3 nuclear factor, interleukin 3 regulated
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PSAT1 phosphoserine aminotransferase 1
PXDN peroxidasin
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEC24D SEC24 family member D
SERP1 stress-associated endoplasmic reticulum protein 1
SIK1 salt-inducible kinase 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
THBS2 thrombospondin 2
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
U2AF1 U2 small nuclear RNA auxiliary factor 1
UFM1 ubiquitin-fold modifier 1
VSIG4 V-set and immunoglobulin domain containing 4
VTCN1 V-set domain containing T cell activation inhibitor 1
WARS tryptophanyl-tRNA synthetase
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ATAD2 ATPase family, AAA domain containing 2
ATF5 activating transcription factor 5
CA2 carbonic anhydrase II
CD58 CD58 molecule
COL4A5 collagen, type IV, alpha 5
DCK deoxycytidine kinase
EFNB2 ephrin-B2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FKBP1B FK506 binding protein 1B, 12.6 kDa
GNG11 guanine nucleotide binding protein (G protein), gamma 11
IGHM immunoglobulin heavy constant mu
LBH limb bud and heart development
MXRA7 matrix-remodelling associated 7
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
THAP11 THAP domain containing 11
TPGS2 tubulin polyglutamylase complex subunit 2
ZNF586 zinc finger protein 586
Funding