BRD-A39969961_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

99 genes differentially expressed following the BRD-A39969961_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
BCL6 B-cell CLL/lymphoma 6
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN3 claudin 3
CP ceruloplasmin (ferroxidase)
CSTA cystatin A (stefin A)
DPP4 dipeptidyl-peptidase 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENO1 enolase 1, (alpha)
F3 coagulation factor III (thromboplastin, tissue factor)
FAM69A family with sequence similarity 69, member A
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GNLY granulysin
HILPDA hypoxia inducible lipid droplet-associated
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHM immunoglobulin heavy constant mu
KCTD5 potassium channel tetramerization domain containing 5
LIMA1 LIM domain and actin binding 1
LOC100505650 uncharacterized LOC100505650
MAOA monoamine oxidase A
MEIS2 Meis homeobox 2
MPPED2 metallophosphoesterase domain containing 2
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
P3H2 prolyl 3-hydroxylase 2
PAX6 paired box 6
PPIC peptidylprolyl isomerase C (cyclophilin C)
RBP1 retinol binding protein 1, cellular
RHOBTB3 Rho-related BTB domain containing 3
RPL31 ribosomal protein L31
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFTPB surfactant protein B
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TMEM158 transmembrane protein 158 (gene/pseudogene)
VEGFA vascular endothelial growth factor A
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
AKR1C3 aldo-keto reductase family 1, member C3
ARHGAP29 Rho GTPase activating protein 29
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
BICC1 BicC family RNA binding protein 1
BRCA1 breast cancer 1, early onset
CCNE2 cyclin E2
COL14A1 collagen, type XIV, alpha 1
COMP cartilage oligomeric matrix protein
CTSK cathepsin K
CXCL12 chemokine (C-X-C motif) ligand 12
CYBA cytochrome b-245, alpha polypeptide
DDB2 damage-specific DNA binding protein 2, 48kDa
DEFB1 defensin, beta 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
FAM171A1 family with sequence similarity 171, member A1
FBN1 fibrillin 1
FLRT2 fibronectin leucine rich transmembrane protein 2
GDF15 growth differentiation factor 15
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX2 glutathione peroxidase 2
HOXC6 homeobox C6
IGF1R insulin-like growth factor 1 receptor
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KDSR 3-ketodihydrosphingosine reductase
KLHL21 kelch-like family member 21
LUC7L3 LUC7-like 3 (S. cerevisiae)
MARCKS myristoylated alanine-rich protein kinase C substrate
MFAP5 microfibrillar associated protein 5
MGLL monoglyceride lipase
MGP matrix Gla protein
NET1 neuroepithelial cell transforming 1
PCDH9 protocadherin 9
PPIF peptidylprolyl isomerase F
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1
RPS27L ribosomal protein S27-like
S100P S100 calcium binding protein P
SCUBE2 signal peptide, CUB domain, EGF-like 2
SFN stratifin
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SRPX sushi-repeat containing protein, X-linked
STOM stomatin
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THBS1 thrombospondin 1
TOB1 transducer of ERBB2, 1
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5
TUBA4A tubulin, alpha 4a
WWP1 WW domain containing E3 ubiquitin protein ligase 1