BRD-A39996500_radicicol_A549_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

190 genes differentially expressed following the BRD-A39996500_radicicol_A549_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AGTR1 angiotensin II receptor, type 1
AK2 adenylate kinase 2
AKR1C2 aldo-keto reductase family 1, member C2
ANOS1 anosmin 1
ASTN2 astrotactin 2
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
BBX bobby sox homolog (Drosophila)
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL3 B-cell CLL/lymphoma 3
BHLHE41 basic helix-loop-helix family, member e41
BID BH3 interacting domain death agonist
BST2 bone marrow stromal cell antigen 2
C6ORF48 chromosome 6 open reading frame 48
C8ORF4 chromosome 8 open reading frame 4
CCL20 chemokine (C-C motif) ligand 20
CD36 CD36 molecule (thrombospondin receptor)
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLU clusterin
COL4A5 collagen, type IV, alpha 5
CRYAB crystallin, alpha B
CYBRD1 cytochrome b reductase 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DACH1 dachshund family transcription factor 1
DAPK1 death-associated protein kinase 1
DICER1 dicer 1, ribonuclease type III
DLK1 delta-like 1 homolog (Drosophila)
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DPYSL3 dihydropyrimidinase-like 3
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
ESRP1 epithelial splicing regulatory protein 1
FABP6 fatty acid binding protein 6, ileal
FBLN1 fibulin 1
FBXO11 F-box protein 11
FTH1 ferritin, heavy polypeptide 1
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GSTM3 glutathione S-transferase mu 3 (brain)
HIST2H2BE histone cluster 2, H2be
HLA-DRA major histocompatibility complex, class II, DR alpha
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HSPA4 heat shock 70kDa protein 4
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IDO1 indoleamine 2,3-dioxygenase 1
IFI27 interferon, alpha-inducible protein 27
IGFBP7 insulin-like growth factor binding protein 7
IL6ST interleukin 6 signal transducer
IL7R interleukin 7 receptor
INSM1 insulinoma-associated 1
IRF6 interferon regulatory factor 6
KAZN kazrin, periplakin interacting protein
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIF5C kinesin family member 5C
KRT6A keratin 6A, type II
LAMP3 lysosomal-associated membrane protein 3
LRRC8D leucine rich repeat containing 8 family, member D
MAOA monoamine oxidase A
MATN2 matrilin 2
MFAP5 microfibrillar associated protein 5
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MTSS1 metastasis suppressor 1
MX2 MX dynamin-like GTPase 2
MYB v-myb avian myeloblastosis viral oncogene homolog
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEFH neurofilament, heavy polypeptide
NPR3 natriuretic peptide receptor 3
NXN nucleoredoxin
P3H2 prolyl 3-hydroxylase 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PBX1 pre-B-cell leukemia homeobox 1
PDZK1 PDZ domain containing 1
PIR pirin (iron-binding nuclear protein)
PRNP prion protein
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PXDN peroxidasin
RAB2A RAB2A, member RAS oncogene family
RBKS ribokinase
SATB1 SATB homeobox 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC4 syndecan 4
SEPP1 selenoprotein P, plasma, 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SPP1 secreted phosphoprotein 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SRPX sushi-repeat containing protein, X-linked
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TICAM1 toll-like receptor adaptor molecule 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNC1 troponin C type 1 (slow)
TNPO1 transportin 1
TPR translocated promoter region, nuclear basket protein
TRIM22 tripartite motif containing 22
TUBB6 tubulin, beta 6 class V
VCAN versican
VWF von Willebrand factor
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AMDHD2 amidohydrolase domain containing 2
ARL4C ADP-ribosylation factor-like 4C
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
CAPN2 calpain 2, (m/II) large subunit
CCDC109B coiled-coil domain containing 109B
CCDC86 coiled-coil domain containing 86
CCNF cyclin F
CD69 CD69 molecule
CDK14 cyclin-dependent kinase 14
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CENPU centromere protein U
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
COL10A1 collagen, type X, alpha 1
CRIP1 cysteine-rich protein 1 (intestinal)
CRIP2 cysteine-rich protein 2
CRISP3 cysteine-rich secretory protein 3
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DHRS2 dehydrogenase/reductase (SDR family) member 2
DUSP6 dual specificity phosphatase 6
ELANE elastase, neutrophil expressed
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
ETV1 ets variant 1
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GGCT gamma-glutamylcyclotransferase
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPER1 G protein-coupled estrogen receptor 1
GREM1 gremlin 1, DAN family BMP antagonist
H1F0 H1 histone family, member 0
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IER2 immediate early response 2
IER3 immediate early response 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
INHBA inhibin, beta A
ITM2A integral membrane protein 2A
KIF14 kinesin family member 14
KLF6 Kruppel-like factor 6
KRAS Kirsten rat sarcoma viral oncogene homolog
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LUM lumican
MAGEA3 melanoma antigen family A3
MAL mal, T-cell differentiation protein
MCL1 myeloid cell leukemia 1
MSX1 msh homeobox 1
NOX4 NADPH oxidase 4
NT5E 5'-nucleotidase, ecto (CD73)
NUSAP1 nucleolar and spindle associated protein 1
PCDH9 protocadherin 9
PDE4B phosphodiesterase 4B, cAMP-specific
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PRKCA protein kinase C, alpha
PRSS3 protease, serine, 3
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RGS4 regulator of G-protein signaling 4
RHOB ras homolog family member B
RRM2 ribonucleotide reductase M2
S100P S100 calcium binding protein P
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPRY2 sprouty homolog 2 (Drosophila)
STEAP1 six transmembrane epithelial antigen of the prostate 1
STMN1 stathmin 1
STX1A syntaxin 1A (brain)
SULF1 sulfatase 1
TCF4 transcription factor 4
THBS2 thrombospondin 2
TUBB2A tubulin, beta 2A class IIa
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UBE2S ubiquitin-conjugating enzyme E2S
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
WSB2 WD repeat and SOCS box containing 2
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
Funding