BRD-A39996500_radicicol_BT20_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

163 genes differentially expressed following the BRD-A39996500_radicicol_BT20_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ALCAM activated leukocyte cell adhesion molecule
ALOX5AP arachidonate 5-lipoxygenase-activating protein
APOC1 apolipoprotein C-I
AQP3 aquaporin 3 (Gill blood group)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
BCL2A1 BCL2-related protein A1
BCL6 B-cell CLL/lymphoma 6
BLVRA biliverdin reductase A
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL20 chemokine (C-C motif) ligand 20
CDK19 cyclin-dependent kinase 19
CLDN8 claudin 8
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
EGF epidermal growth factor
EMX2 empty spiracles homeobox 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM13A family with sequence similarity 13, member A
FASTKD5 FAST kinase domains 5
FTH1 ferritin, heavy polypeptide 1
GDF15 growth differentiation factor 15
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLUL glutamate-ammonia ligase
HES1 hes family bHLH transcription factor 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
JMJD6 jumonji domain containing 6
KLHDC10 kelch domain containing 10
KRT13 keratin 13, type I
MAOA monoamine oxidase A
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MKNK1 MAP kinase interacting serine/threonine kinase 1
MLPH melanophilin
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NUPR1 nuclear protein, transcriptional regulator, 1
P3H2 prolyl 3-hydroxylase 2
POPDC3 popeye domain containing 3
PRAME preferentially expressed antigen in melanoma
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RHOBTB3 Rho-related BTB domain containing 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPL38 ribosomal protein L38
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLIT2 slit homolog 2 (Drosophila)
SORBS2 sorbin and SH3 domain containing 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRGN serglycin
STC1 stanniocalcin 1
STK17A serine/threonine kinase 17a
TACC2 transforming, acidic coiled-coil containing protein 2
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TMCO1 transmembrane and coiled-coil domains 1
TMEM45A transmembrane protein 45A
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMDHD2 amidohydrolase domain containing 2
ANXA1 annexin A1
ANXA3 annexin A3
AREG amphiregulin
ASPN asporin
BST2 bone marrow stromal cell antigen 2
CAB39 calcium binding protein 39
CARD10 caspase recruitment domain family, member 10
CAV1 caveolin 1, caveolae protein, 22kDa
CCND2 cyclin D2
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CDC45 cell division cycle 45
CDK4 cyclin-dependent kinase 4
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEP170 centrosomal protein 170kDa
COL10A1 collagen, type X, alpha 1
CRIP2 cysteine-rich protein 2
CRISP3 cysteine-rich secretory protein 3
CXCL12 chemokine (C-X-C motif) ligand 12
CYR61 cysteine-rich, angiogenic inducer, 61
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNM1L dynamin 1-like
EBP emopamil binding protein (sterol isomerase)
ECM1 extracellular matrix protein 1
ELN elastin
EPCAM epithelial cell adhesion molecule
EREG epiregulin
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAS Fas cell surface death receptor
GMDS GDP-mannose 4,6-dehydratase
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HN1 hematological and neurological expressed 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGF1R insulin-like growth factor 1 receptor
IL17RB interleukin 17 receptor B
INHBA inhibin, beta A
ITGA6 integrin, alpha 6
ITGB4 integrin, beta 4
LAMC2 laminin, gamma 2
LGALS3 lectin, galactoside-binding, soluble, 3
LTBP1 latent transforming growth factor beta binding protein 1
MAB21L2 mab-21-like 2 (C. elegans)
MAPK13 mitogen-activated protein kinase 13
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
MCM4 minichromosome maintenance complex component 4
MDK midkine (neurite growth-promoting factor 2)
MMP11 matrix metallopeptidase 11
MN1 meningioma (disrupted in balanced translocation) 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYOF myoferlin
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIB nuclear factor I/B
OAT ornithine aminotransferase
OLFM4 olfactomedin 4
PAM peptidylglycine alpha-amidating monooxygenase
PDGFD platelet derived growth factor D
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAU plasminogen activator, urokinase
PLEC plectin
PNP purine nucleoside phosphorylase
POSTN periostin, osteoblast specific factor
PRDX4 peroxiredoxin 4
PRSS2 protease, serine, 2 (trypsin 2)
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RBM34 RNA binding motif protein 34
RBP1 retinol binding protein 1, cellular
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SCG5 secretogranin V
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC35F2 solute carrier family 35, member F2
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SOBP sine oculis binding protein homolog (Drosophila)
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SRSF6 serine/arginine-rich splicing factor 6
SYNGR3 synaptogyrin 3
TFPI2 tissue factor pathway inhibitor 2
TGFA transforming growth factor, alpha
THBS1 thrombospondin 1
TPM1 tropomyosin 1 (alpha)
TUBB6 tubulin, beta 6 class V
VCAN versican
ZFPM2 zinc finger protein, FOG family member 2
Funding