BRD-A39996500_radicicol_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

273 genes differentially expressed following the BRD-A39996500_radicicol_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABHD4 abhydrolase domain containing 4
AFF1 AF4/FMR2 family, member 1
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AKAP8L A kinase (PRKA) anchor protein 8-like
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANGPT1 angiopoietin 1
AQP1 aquaporin 1 (Colton blood group)
ASPN asporin
ASS1 argininosuccinate synthase 1
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
C5ORF30 chromosome 5 open reading frame 30
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CCNA1 cyclin A1
CDK19 cyclin-dependent kinase 19
CES1 carboxylesterase 1
CLEC3B C-type lectin domain family 3, member B
CLU clusterin
COL4A5 collagen, type IV, alpha 5
COL5A2 collagen, type V, alpha 2
CRABP1 cellular retinoic acid binding protein 1
CRELD2 cysteine-rich with EGF-like domains 2
CRYAB crystallin, alpha B
CTH cystathionine gamma-lyase
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPHA3 EPH receptor A3
FAM171A1 family with sequence similarity 171, member A1
FKBP14 FK506 binding protein 14, 22 kDa
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GATA3 GATA binding protein 3
GCLM glutamate-cysteine ligase, modifier subunit
GLUL glutamate-ammonia ligase
GPC3 glypican 3
GPX2 glutathione peroxidase 2
GPX3 glutathione peroxidase 3
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H2AC histone cluster 1, H2ac
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KL klotho
KRT13 keratin 13, type I
KRT4 keratin 4, type II
LPL lipoprotein lipase
MAL mal, T-cell differentiation protein
MAOA monoamine oxidase A
MAP1A microtubule-associated protein 1A
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEIS2 Meis homeobox 2
MFAP5 microfibrillar associated protein 5
MMP3 matrix metallopeptidase 3
MSMO1 methylsterol monooxygenase 1
MYBPC1 myosin binding protein C, slow type
MYL9 myosin, light chain 9, regulatory
NEBL nebulette
NKX3-1 NK3 homeobox 1
NOTCH3 notch 3
NQO1 NAD(P)H dehydrogenase, quinone 1
NRCAM neuronal cell adhesion molecule
ODC1 ornithine decarboxylase 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCDH9 protocadherin 9
PCYOX1 prenylcysteine oxidase 1
PENK proenkephalin
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIR pirin (iron-binding nuclear protein)
PITRM1 pitrilysin metallopeptidase 1
PLCB4 phospholipase C, beta 4
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRELP proline/arginine-rich end leucine-rich repeat protein
PSAP prosaposin
PTX3 pentraxin 3, long
QPRT quinolinate phosphoribosyltransferase
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS2 regulator of G-protein signaling 2
RYBP RING1 and YY1 binding protein
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLIT2 slit homolog 2 (Drosophila)
SORD sorbitol dehydrogenase
SPP1 secreted phosphoprotein 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SRP19 signal recognition particle 19kDa
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STMN2 stathmin 2
STOM stomatin
TAGLN transgelin
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
THBS4 thrombospondin 4
TIMP3 TIMP metallopeptidase inhibitor 3
TKT transketolase
TNNC1 troponin C type 1 (slow)
TOR1A torsin family 1, member A (torsin A)
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
VAV3 vav 3 guanine nucleotide exchange factor
VWF von Willebrand factor
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
AKAP12 A kinase (PRKA) anchor protein 12
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD10 ankyrin repeat domain 10
ARL4C ADP-ribosylation factor-like 4C
ASF1B anti-silencing function 1B histone chaperone
ASRGL1 asparaginase like 1
BHLHE40 basic helix-loop-helix family, member e40
BRCA1 breast cancer 1, early onset
BTBD3 BTB (POZ) domain containing 3
C1ORF106 chromosome 1 open reading frame 106
CALML5 calmodulin-like 5
CAPN1 calpain 1, (mu/I) large subunit
CAPN2 calpain 2, (m/II) large subunit
CCDC109B coiled-coil domain containing 109B
CCL2 chemokine (C-C motif) ligand 2
CCNE2 cyclin E2
CD200 CD200 molecule
CD24 CD24 molecule
CD302 CD302 molecule
CD9 CD9 molecule
CDC45 cell division cycle 45
CDC7 cell division cycle 7
CDCA4 cell division cycle associated 4
CDK14 cyclin-dependent kinase 14
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDT1 chromatin licensing and DNA replication factor 1
CELF2 CUGBP, Elav-like family member 2
CENPU centromere protein U
CHGB chromogranin B
CKLF chemokine-like factor
CSTA cystatin A (stefin A)
CTSE cathepsin E
CXCL2 chemokine (C-X-C motif) ligand 2
DHFR dihydrofolate reductase
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DPYD dihydropyrimidine dehydrogenase
DPYSL2 dihydropyrimidinase-like 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
DUT deoxyuridine triphosphatase
EDNRA endothelin receptor type A
EFHD2 EF-hand domain family, member D2
EGR3 early growth response 3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
ENO2 enolase 2 (gamma, neuronal)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHB2 EPH receptor B2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FXYD3 FXYD domain containing ion transport regulator 3
FXYD6 FXYD domain containing ion transport regulator 6
GATA2 GATA binding protein 2
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GSAP gamma-secretase activating protein
H1F0 H1 histone family, member 0
HELLS helicase, lymphoid-specific
HES1 hes family bHLH transcription factor 1
HNMT histamine N-methyltransferase
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IGFBP7 insulin-like growth factor binding protein 7
IL17RB interleukin 17 receptor B
JUN jun proto-oncogene
KCTD12 potassium channel tetramerization domain containing 12
KIAA0226L KIAA0226-like
KLF4 Kruppel-like factor 4 (gut)
KRT17 keratin 17, type I
LIF leukemia inhibitory factor
LIG1 ligase I, DNA, ATP-dependent
MARCKSL1 MARCKS-like 1
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MMP7 matrix metallopeptidase 7
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MUC1 mucin 1, cell surface associated
MUC16 mucin 16, cell surface associated
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NPIPB3 nuclear pore complex interacting protein family, member B3
NR2F2 nuclear receptor subfamily 2, group F, member 2
OSBPL10 oxysterol binding protein-like 10
PAQR4 progestin and adipoQ receptor family member IV
PCNA proliferating cell nuclear antigen
PCSK1 proprotein convertase subtilisin/kexin type 1
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAT plasminogen activator, tissue
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PNMA2 paraneoplastic Ma antigen 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPAP2C phosphatidic acid phosphatase type 2C
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRSS3 protease, serine, 3
PSPH phosphoserine phosphatase
PXMP2 peroxisomal membrane protein 2, 22kDa
QPCT glutaminyl-peptide cyclotransferase
RAB31 RAB31, member RAS oncogene family
RAD51AP1 RAD51 associated protein 1
RBBP8 retinoblastoma binding protein 8
RFC2 replication factor C (activator 1) 2, 40kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRM2 ribonucleotide reductase M2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SMAD7 SMAD family member 7
SNAI2 snail family zinc finger 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX9 SRY (sex determining region Y)-box 9
SPON1 spondin 1, extracellular matrix protein
SPRY4 sprouty homolog 4 (Drosophila)
STEAP3 STEAP family member 3, metalloreductase
SYNJ2 synaptojanin 2
TACSTD2 tumor-associated calcium signal transducer 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
TIAM1 T-cell lymphoma invasion and metastasis 1
TK1 thymidine kinase 1, soluble
TM4SF1 transmembrane 4 L six family member 1
TMEM106C transmembrane protein 106C
TNC tenascin C
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIB2 tribbles pseudokinase 2
TRMT5 tRNA methyltransferase 5
TSPAN12 tetraspanin 12
TYMS thymidylate synthetase
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
USP1 ubiquitin specific peptidase 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WNT5A wingless-type MMTV integration site family, member 5A
WSB2 WD repeat and SOCS box containing 2
ZWINT ZW10 interacting kinetochore protein
Funding