BRD-A39996500_radicicol_HME1_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

325 genes differentially expressed following the BRD-A39996500_radicicol_HME1_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ADAM17 ADAM metallopeptidase domain 17
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADI1 acireductone dioxygenase 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDOC aldolase C, fructose-bisphosphate
APOL1 apolipoprotein L, 1
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
ATRX alpha thalassemia/mental retardation syndrome X-linked
AVPI1 arginine vasopressin-induced 1
BMP7 bone morphogenetic protein 7
BPTF bromodomain PHD finger transcription factor
BRD2 bromodomain containing 2
BRD4 bromodomain containing 4
C1S complement component 1, s subcomponent
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD58 CD58 molecule
CDK19 cyclin-dependent kinase 19
CELF2 CUGBP, Elav-like family member 2
CES1 carboxylesterase 1
CHPT1 choline phosphotransferase 1
CLU clusterin
COL2A1 collagen, type II, alpha 1
CRABP1 cellular retinoic acid binding protein 1
CREB1 cAMP responsive element binding protein 1
CREBBP CREB binding protein
CTSA cathepsin A
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ELF4 E74-like factor 4 (ets domain transcription factor)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FADS1 fatty acid desaturase 1
FAM117A family with sequence similarity 117, member A
FAM13B family with sequence similarity 13, member B
FBXO11 F-box protein 11
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GABARAPL1 GABA(A) receptor-associated protein like 1
GATA3 GATA binding protein 3
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GLA galactosidase, alpha
GPNMB glycoprotein (transmembrane) nmb
GRN granulin
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
KDM2A lysine (K)-specific demethylase 2A
KDM3A lysine (K)-specific demethylase 3A
KEAP1 kelch-like ECH-associated protein 1
KLHL24 kelch-like family member 24
KRT13 keratin 13, type I
KRT6A keratin 6A, type II
LBH limb bud and heart development
LRP4 low density lipoprotein receptor-related protein 4
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
NCOA3 nuclear receptor coactivator 3
NDRG1 N-myc downstream regulated 1
NEU1 sialidase 1 (lysosomal sialidase)
NKTR natural killer cell triggering receptor
NQO1 NAD(P)H dehydrogenase, quinone 1
NUPR1 nuclear protein, transcriptional regulator, 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDIA3 protein disulfide isomerase family A, member 3
PIEZO2 piezo-type mechanosensitive ion channel component 2
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIR pirin (iron-binding nuclear protein)
PLIN2 perilipin 2
POR P450 (cytochrome) oxidoreductase
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRRC2C proline-rich coiled-coil 2C
PSAP prosaposin
QPRT quinolinate phosphoribosyltransferase
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RB1CC1 RB1-inducible coiled-coil 1
RBBP6 retinoblastoma binding protein 6
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RND3 Rho family GTPase 3
RNF114 ring finger protein 114
RRAGC Ras-related GTP binding C
S100A4 S100 calcium binding protein A4
S100A8 S100 calcium binding protein A8
SAR1A secretion associated, Ras related GTPase 1A
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SECISBP2L SECIS binding protein 2-like
SERINC5 serine incorporator 5
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFN stratifin
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOD1 superoxide dismutase 1, soluble
SOS1 son of sevenless homolog 1 (Drosophila)
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SQSTM1 sequestosome 1
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STK38 serine/threonine kinase 38
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TALDO1 transaldolase 1
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
THUMPD1 THUMP domain containing 1
TLK1 tousled-like kinase 1
TNPO1 transportin 1
TRAF5 TNF receptor-associated factor 5
TUFT1 tuftelin 1
TXNRD1 thioredoxin reductase 1
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UBXN4 UBX domain protein 4
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGDH UDP-glucose 6-dehydrogenase
USP3 ubiquitin specific peptidase 3
USP47 ubiquitin specific peptidase 47
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
USP9X ubiquitin specific peptidase 9, X-linked
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WNK1 WNK lysine deficient protein kinase 1
WWP1 WW domain containing E3 ubiquitin protein ligase 1
YPEL5 yippee-like 5 (Drosophila)
ZMYM2 zinc finger, MYM-type 2
ZNF292 zinc finger protein 292

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTN1 actinin, alpha 1
AHCY adenosylhomocysteinase
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
C1QBP complement component 1, q subcomponent binding protein
C2CD5 C2 calcium-dependent domain containing 5
C3 complement component 3
C3ORF14 chromosome 3 open reading frame 14
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCND1 cyclin D1
CCNE2 cyclin E2
CD200 CD200 molecule
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CDC45 cell division cycle 45
CDK4 cyclin-dependent kinase 4
CHGB chromogranin B
COL10A1 collagen, type X, alpha 1
COL15A1 collagen, type XV, alpha 1
COL1A2 collagen, type I, alpha 2
CSTA cystatin A (stefin A)
CXCL8 chemokine (C-X-C motif) ligand 8
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDB2 damage-specific DNA binding protein 2, 48kDa
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUT deoxyuridine triphosphatase
EDNRA endothelin receptor type A
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
EREG epiregulin
ESRP1 epithelial splicing regulatory protein 1
ETV1 ets variant 1
ETV5 ets variant 5
EXOSC2 exosome component 2
F3 coagulation factor III (thromboplastin, tissue factor)
FAM129A family with sequence similarity 129, member A
FEN1 flap structure-specific endonuclease 1
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli)
GEM GTP binding protein overexpressed in skeletal muscle
GJA1 gap junction protein, alpha 1, 43kDa
HBEGF heparin-binding EGF-like growth factor
HMGA2 high mobility group AT-hook 2
HOPX HOP homeobox
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IGFBP7 insulin-like growth factor binding protein 7
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RAP interleukin 1 receptor accessory protein
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INHBA inhibin, beta A
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
JAG1 jagged 1
KCTD12 potassium channel tetramerization domain containing 12
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
LAMB1 laminin, beta 1
LAMC2 laminin, gamma 2
LGALS1 lectin, galactoside-binding, soluble, 1
LHFP lipoma HMGIC fusion partner
LIG1 ligase I, DNA, ATP-dependent
LMNB2 lamin B2
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LUM lumican
MALL mal, T-cell differentiation protein-like
MAP7 microtubule-associated protein 7
MAPT microtubule-associated protein tau
MCF2L MCF.2 cell line derived transforming sequence-like
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MGP matrix Gla protein
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP9 matrix metallopeptidase 9
MRPL15 mitochondrial ribosomal protein L15
MRPL24 mitochondrial ribosomal protein L24
MRPL3 mitochondrial ribosomal protein L3
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV3 neuron navigator 3
NBN nibrin
NME1 NME/NM23 nucleoside diphosphate kinase 1
NREP neuronal regeneration related protein
NRP1 neuropilin 1
NT5E 5'-nucleotidase, ecto (CD73)
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFC platelet derived growth factor C
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PEBP1 phosphatidylethanolamine binding protein 1
PFDN2 prefoldin subunit 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLSCR1 phospholipid scramblase 1
PNP purine nucleoside phosphorylase
POSTN periostin, osteoblast specific factor
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PYGL phosphorylase, glycogen, liver
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RANBP1 RAN binding protein 1
RBPMS RNA binding protein with multiple splicing
RFC2 replication factor C (activator 1) 2, 40kDa
RFTN1 raftlin, lipid raft linker 1
RGS1 regulator of G-protein signaling 1
RGS5 regulator of G-protein signaling 5
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RTN1 reticulon 1
RUVBL1 RuvB-like AAA ATPase 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPATS2L spermatogenesis associated, serine-rich 2-like
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRM spermidine synthase
SRPX sushi-repeat containing protein, X-linked
SRSF7 serine/arginine-rich splicing factor 7
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STC1 stanniocalcin 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STEAP3 STEAP family member 3, metalloreductase
SVIL supervillin
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN2 transgelin 2
TARBP1 TAR (HIV-1) RNA binding protein 1
TFDP1 transcription factor Dp-1
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBD thrombomodulin
THBS1 thrombospondin 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIMP1 TIMP metallopeptidase inhibitor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRAPPC4 trafficking protein particle complex 4
TSC22D3 TSC22 domain family, member 3
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UPP1 uridine phosphorylase 1
VCAN versican
WWTR1 WW domain containing transcription regulator 1
Funding