BRD-A39996500_radicicol_MDAMB231_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

274 genes differentially expressed following the BRD-A39996500_radicicol_MDAMB231_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABHD4 abhydrolase domain containing 4
ADA adenosine deaminase
ADAM10 ADAM metallopeptidase domain 10
ADGRG2 adhesion G protein-coupled receptor G2
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AKR1C1 aldo-keto reductase family 1, member C1
APOL1 apolipoprotein L, 1
ASS1 argininosuccinate synthase 1
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BRD8 bromodomain containing 8
C1QB complement component 1, q subcomponent, B chain
C1S complement component 1, s subcomponent
CALR calreticulin
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CHI3L2 chitinase 3-like 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKS2 CDC28 protein kinase regulatory subunit 2
COL5A1 collagen, type V, alpha 1
CRABP1 cellular retinoic acid binding protein 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTSV cathepsin V
CXCL5 chemokine (C-X-C motif) ligand 5
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DAPK1 death-associated protein kinase 1
DAZAP2 DAZ associated protein 2
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DHRS3 dehydrogenase/reductase (SDR family) member 3
DHRS7 dehydrogenase/reductase (SDR family) member 7
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EGFL6 EGF-like-domain, multiple 6
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FADS1 fatty acid desaturase 1
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GAB2 GRB2-associated binding protein 2
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GPC1 glypican 1
HIC2 hypermethylated in cancer 2
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IGHMBP2 immunoglobulin mu binding protein 2
IGKV4-1 immunoglobulin kappa variable 4-1
INSR insulin receptor
ITM2C integral membrane protein 2C
JMJD6 jumonji domain containing 6
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KDM3A lysine (K)-specific demethylase 3A
KIF14 kinesin family member 14
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAMP3 lysosomal-associated membrane protein 3
LBH limb bud and heart development
LCN2 lipocalin 2
LDHB lactate dehydrogenase B
MAGED1 melanoma antigen family D1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEIS2 Meis homeobox 2
MSMO1 methylsterol monooxygenase 1
NOTCH3 notch 3
NQO1 NAD(P)H dehydrogenase, quinone 1
NUSAP1 nucleolar and spindle associated protein 1
NXN nucleoredoxin
OSBPL9 oxysterol binding protein-like 9
P3H2 prolyl 3-hydroxylase 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PFN2 profilin 2
PI3 peptidase inhibitor 3, skin-derived
PIR pirin (iron-binding nuclear protein)
QPRT quinolinate phosphoribosyltransferase
RAP1GAP RAP1 GTPase activating protein
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
SC5D sterol-C5-desaturase
SELENBP1 selenium binding protein 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLIT2 slit homolog 2 (Drosophila)
SLPI secretory leukocyte peptidase inhibitor
SMCO4 single-pass membrane protein with coiled-coil domains 4
SORD sorbitol dehydrogenase
SPON2 spondin 2, extracellular matrix protein
SQLE squalene epoxidase
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SV2C synaptic vesicle glycoprotein 2C
TAC1 tachykinin, precursor 1
TBX3 T-box 3
TLK2 tousled-like kinase 2
TRIM2 tripartite motif containing 2
TSPAN13 tetraspanin 13
UFM1 ubiquitin-fold modifier 1
WFS1 Wolfram syndrome 1 (wolframin)
WSB1 WD repeat and SOCS box containing 1
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZNF266 zinc finger protein 266
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACOT9 acyl-CoA thioesterase 9
ACTB actin, beta
ADIRF adipogenesis regulatory factor
ADRB2 adrenoceptor beta 2, surface
AHR aryl hydrocarbon receptor
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
ANK2 ankyrin 2, neuronal
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ARL4C ADP-ribosylation factor-like 4C
ARMCX1 armadillo repeat containing, X-linked 1
AXL AXL receptor tyrosine kinase
BRCA1 breast cancer 1, early onset
CAPN2 calpain 2, (m/II) large subunit
CCNE2 cyclin E2
CD24 CD24 molecule
CD302 CD302 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD58 CD58 molecule
CEP170 centrosomal protein 170kDa
CKLF chemokine-like factor
CLC Charcot-Leyden crystal galectin
COL13A1 collagen, type XIII, alpha 1
COTL1 coactosin-like F-actin binding protein 1
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CXCR4 chemokine (C-X-C motif) receptor 4
CYR61 cysteine-rich, angiogenic inducer, 61
DCK deoxycytidine kinase
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHFR dihydrofolate reductase
DLC1 DLC1 Rho GTPase activating protein
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DPYSL2 dihydropyrimidinase-like 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
E2F2 E2F transcription factor 2
EIF5A eukaryotic translation initiation factor 5A
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPS8 epidermal growth factor receptor pathway substrate 8
EREG epiregulin
ESR1 estrogen receptor 1
ETV1 ets variant 1
F3 coagulation factor III (thromboplastin, tissue factor)
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GNAS GNAS complex locus
GPM6A glycoprotein M6A
GRIA2 glutamate receptor, ionotropic, AMPA 2
HBEGF heparin-binding EGF-like growth factor
HMGA1 high mobility group AT-hook 1
HNMT histamine N-methyltransferase
IER3 immediate early response 3
IGFBP7 insulin-like growth factor binding protein 7
ITGA6 integrin, alpha 6
JUN jun proto-oncogene
KCTD12 potassium channel tetramerization domain containing 12
KLF4 Kruppel-like factor 4 (gut)
KRT23 keratin 23, type I
LGALS1 lectin, galactoside-binding, soluble, 1
MALL mal, T-cell differentiation protein-like
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MET MET proto-oncogene, receptor tyrosine kinase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MPZL2 myelin protein zero-like 2
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTMR11 myotubularin related protein 11
MTSS1 metastasis suppressor 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYH11 myosin, heavy chain 11, smooth muscle
NAV3 neuron navigator 3
NELL2 NEL-like 2 (chicken)
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRN1 neuritin 1
NRP1 neuropilin 1
NT5E 5'-nucleotidase, ecto (CD73)
OLFM4 olfactomedin 4
OSBPL10 oxysterol binding protein-like 10
PAM peptidylglycine alpha-amidating monooxygenase
PCLO piccolo presynaptic cytomatrix protein
PCNA proliferating cell nuclear antigen
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDGFC platelet derived growth factor C
PEG10 paternally expressed 10
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLN phospholamban
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRSS3 protease, serine, 3
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PYCARD PYD and CARD domain containing
QPCT glutaminyl-peptide cyclotransferase
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RFTN1 raftlin, lipid raft linker 1
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A2 S100 calcium binding protein A2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SMYD2 SET and MYND domain containing 2
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SPATS2L spermatogenesis associated, serine-rich 2-like
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
STEAP3 STEAP family member 3, metalloreductase
STX1A syntaxin 1A (brain)
TACSTD2 tumor-associated calcium signal transducer 2
TFF3 trefoil factor 3 (intestinal)
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TOX3 TOX high mobility group box family member 3
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN5 tetraspanin 5
TUBG1 tubulin, gamma 1
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VCAN versican
VEGFC vascular endothelial growth factor C
VIM vimentin
WSB2 WD repeat and SOCS box containing 2
WWTR1 WW domain containing transcription regulator 1
ZBTB18 zinc finger and BTB domain containing 18
Funding