BRD-A41250203_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

92 genes differentially expressed following the BRD-A41250203_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1C2 aldo-keto reductase family 1, member C2
APOC1 apolipoprotein C-I
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BASP1 brain abundant, membrane attached signal protein 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CECR1 cat eye syndrome chromosome region, candidate 1
CEMIP cell migration inducing protein, hyaluronan binding
CLDN10 claudin 10
COBL cordon-bleu WH2 repeat protein
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP5 dual specificity phosphatase 5
ELANE elastase, neutrophil expressed
FGFR3 fibroblast growth factor receptor 3
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
H2BFS H2B histone family, member S (pseudogene)
HBB hemoglobin, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIC2 hypermethylated in cancer 2
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
LOC100505650 uncharacterized LOC100505650
MALL mal, T-cell differentiation protein-like
NAMPT nicotinamide phosphoribosyltransferase
NAV3 neuron navigator 3
NELL2 NEL-like 2 (chicken)
NFIL3 nuclear factor, interleukin 3 regulated
NID2 nidogen 2 (osteonidogen)
P3H2 prolyl 3-hydroxylase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SERTAD2 SERTA domain containing 2
SH3GLB1 SH3-domain GRB2-like endophilin B1
SHROOM2 shroom family member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SRGN serglycin
STAR steroidogenic acute regulatory protein
TBC1D4 TBC1 domain family, member 4
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ATF5 activating transcription factor 5
B3GNT1
BAMBI BMP and activin membrane-bound inhibitor
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
ESR1 estrogen receptor 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATA3 GATA binding protein 3
GINS1 GINS complex subunit 1 (Psf1 homolog)
H1F0 H1 histone family, member 0
HDGFRP3 hepatoma-derived growth factor, related protein 3
HES1 hes family bHLH transcription factor 1
MREG melanoregulin
MXRA7 matrix-remodelling associated 7
NFIB nuclear factor I/B
NRIP1 nuclear receptor interacting protein 1
PLIN1 perilipin 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TOX thymocyte selection-associated high mobility group box
Funding