BRD-A43155244_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

178 genes differentially expressed following the BRD-A43155244_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ARC activity-regulated cytoskeleton-associated protein
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
BLNK B-cell linker
BTG2 BTG family, member 2
C1QA complement component 1, q subcomponent, A chain
CCDC68 coiled-coil domain containing 68
CD200 CD200 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLU clusterin
COL1A1 collagen, type I, alpha 1
COL6A1 collagen, type VI, alpha 1
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF1 eukaryotic translation initiation factor 1
EIF5 eukaryotic translation initiation factor 5
ELANE elastase, neutrophil expressed
FILIP1L filamin A interacting protein 1-like
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GAB2 GRB2-associated binding protein 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAS6 growth arrest-specific 6
GATA2 GATA binding protein 2
GSE1 Gse1 coiled-coil protein
HBB hemoglobin, beta
HBD hemoglobin, delta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H1C histone cluster 1, H1c
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
IRF1 interferon regulatory factor 1
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KIAA0226L KIAA0226-like
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLK5 kallikrein-related peptidase 5
KLK8 kallikrein-related peptidase 8
LOC100505650 uncharacterized LOC100505650
LXN latexin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MEF2C myocyte enhancer factor 2C
MEG3 maternally expressed 3 (non-protein coding)
MMP1 matrix metallopeptidase 1
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MSX1 msh homeobox 1
MT1M metallothionein 1M
MUC16 mucin 16, cell surface associated
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
ODC1 ornithine decarboxylase 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCDH17 protocadherin 17
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTPRO protein tyrosine phosphatase, receptor type, O
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCN3A sodium channel, voltage gated, type III alpha subunit
SRGN serglycin
SST somatostatin
TCF4 transcription factor 4
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIB1 tribbles pseudokinase 1
TXNL4B thioredoxin-like 4B
TYROBP TYRO protein tyrosine kinase binding protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VWF von Willebrand factor
XBP1 X-box binding protein 1
YPEL5 yippee-like 5 (Drosophila)
ZC3HAV1 zinc finger CCCH-type, antiviral 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACP6 acid phosphatase 6, lysophosphatidic
ADARB1 adenosine deaminase, RNA-specific, B1
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
AK4 adenylate kinase 4
AKR1C3 aldo-keto reductase family 1, member C3
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF6 activating transcription factor 6
ATP13A3 ATPase type 13A3
B3GNT1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BLCAP bladder cancer associated protein
BST2 bone marrow stromal cell antigen 2
CA12 carbonic anhydrase XII
CCNF cyclin F
CNPY2 canopy FGF signaling regulator 2
COL4A5 collagen, type IV, alpha 5
CXCL8 chemokine (C-X-C motif) ligand 8
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DST dystonin
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ERBB3 erb-b2 receptor tyrosine kinase 3
EXOSC4 exosome component 4
EXOSC7 exosome component 7
FAM129A family with sequence similarity 129, member A
FEN1 flap structure-specific endonuclease 1
FLJ10038 uncharacterized protein FLJ10038
FNDC3B fibronectin type III domain containing 3B
FXYD3 FXYD domain containing ion transport regulator 3
GOLGA8A golgin A8 family, member A
GP2 glycoprotein 2 (zymogen granule membrane)
GPX2 glutathione peroxidase 2
GRWD1 glutamate-rich WD repeat containing 1
HOXA10 homeobox A10
IGF1R insulin-like growth factor 1 receptor
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KANK1 KN motif and ankyrin repeat domains 1
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KIAA0391 KIAA0391
KIAA0907 KIAA0907
KLF9 Kruppel-like factor 9
KLHL9 kelch-like family member 9
KRT17 keratin 17, type I
MARCKS myristoylated alanine-rich protein kinase C substrate
NAV2 neuron navigator 2
NFIB nuclear factor I/B
NREP neuronal regeneration related protein
PRPF4 pre-mRNA processing factor 4
PRSS23 protease, serine, 23
QDPR quinoid dihydropteridine reductase
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
SCAND1 SCAN domain containing 1
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SPTSSA serine palmitoyltransferase, small subunit A
SRPX sushi-repeat containing protein, X-linked
SRSF11 serine/arginine-rich splicing factor 11
SVIL supervillin
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TMEM43 transmembrane protein 43
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TXNDC9 thioredoxin domain containing 9
VGLL4 vestigial-like family member 4
ZBED5 zinc finger, BED-type containing 5
ZCCHC24 zinc finger, CCHC domain containing 24