BRD-A43640821_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

60 genes differentially expressed following the BRD-A43640821_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADAMDEC1 ADAM-like, decysin 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1C1 aldo-keto reductase family 1, member C1
ALB albumin
APOB apolipoprotein B
ATF3 activating transcription factor 3
BEX4 brain expressed, X-linked 4
BPHL biphenyl hydrolase-like (serine hydrolase)
BTG2 BTG family, member 2
CLC Charcot-Leyden crystal galectin
CLCA1 chloride channel accessory 1
CXCR4 chemokine (C-X-C motif) receptor 4
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FABP1 fatty acid binding protein 1, liver
FILIP1L filamin A interacting protein 1-like
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GREM1 gremlin 1, DAN family BMP antagonist
GSE1 Gse1 coiled-coil protein
HIST1H3H histone cluster 1, H3h
IL17RB interleukin 17 receptor B
JCHAIN joining chain of multimeric IgA and IgM
LPAR6 lysophosphatidic acid receptor 6
MMP1 matrix metallopeptidase 1
MMP7 matrix metallopeptidase 7
OLFM4 olfactomedin 4
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RCAN2 regulator of calcineurin 2
RGCC regulator of cell cycle
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SOX17 SRY (sex determining region Y)-box 17
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON1 spondin 1, extracellular matrix protein
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
THBS1 thrombospondin 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

decreased expression

Symbol Name
CCND1 cyclin D1
FSTL1 follistatin-like 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IGFBP4 insulin-like growth factor binding protein 4
MRPS16 mitochondrial ribosomal protein S16
NOLC1 nucleolar and coiled-body phosphoprotein 1
PRDX1 peroxiredoxin 1
PRDX2 peroxiredoxin 2
RET ret proto-oncogene
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TNC tenascin C
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TSPAN3 tetraspanin 3
VCL vinculin
YME1L1 YME1-like 1 ATPase