BRD-A43882281_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

88 genes differentially expressed following the BRD-A43882281_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ATP7A ATPase, Cu++ transporting, alpha polypeptide
BGN biglycan
BST2 bone marrow stromal cell antigen 2
CA2 carbonic anhydrase II
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC86 coiled-coil domain containing 86
CD40 CD40 molecule, TNF receptor superfamily member 5
CD52 CD52 molecule
CD9 CD9 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CECR1 cat eye syndrome chromosome region, candidate 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLIC5 chloride intracellular channel 5
CPB1 carboxypeptidase B1 (tissue)
CRABP2 cellular retinoic acid binding protein 2
CYTIP cytohesin 1 interacting protein
DENND1B DENN/MADD domain containing 1B
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
FAM198B family with sequence similarity 198, member B
FBXL7 F-box and leucine-rich repeat protein 7
FOXO1 forkhead box O1
FTH1 ferritin, heavy polypeptide 1
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
HK2 hexokinase 2
HOPX HOP homeobox
IFNAR1 interferon (alpha, beta and omega) receptor 1
LEF1 lymphoid enhancer-binding factor 1
LPL lipoprotein lipase
MARCKS myristoylated alanine-rich protein kinase C substrate
MME membrane metallo-endopeptidase
NELL2 NEL-like 2 (chicken)
PBX3 pre-B-cell leukemia homeobox 3
PLIN2 perilipin 2
POU2AF1 POU class 2 associating factor 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RFTN1 raftlin, lipid raft linker 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RSU1 Ras suppressor protein 1
SCGB1D2 secretoglobin, family 1D, member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SNX7 sorting nexin 7
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SULF1 sulfatase 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMSB15A thymosin beta 15a
TPD52 tumor protein D52
TPD52L1 tumor protein D52-like 1
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZNF586 zinc finger protein 586
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AKAP7 A kinase (PRKA) anchor protein 7
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
CHMP4A charged multivesicular body protein 4A
CHPT1 choline phosphotransferase 1
COG7 component of oligomeric golgi complex 7
COPS7A COP9 signalosome subunit 7A
CST3 cystatin C
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
FADS1 fatty acid desaturase 1
FXYD2 FXYD domain containing ion transport regulator 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXC6 homeobox C6
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5
KLF4 Kruppel-like factor 4 (gut)
KRAS Kirsten rat sarcoma viral oncogene homolog
MLF1 myeloid leukemia factor 1
NUP85 nucleoporin 85kDa
PLAGL1 pleiomorphic adenoma gene-like 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SRPX sushi-repeat containing protein, X-linked
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TUBA1A tubulin, alpha 1a
TXLNA taxilin alpha
WSB2 WD repeat and SOCS box containing 2