BRD-A45333398_PERIPLOCYMARIN_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

128 genes differentially expressed following the BRD-A45333398_PERIPLOCYMARIN_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACADVL acyl-CoA dehydrogenase, very long chain
ACTN4 actinin, alpha 4
ADM adrenomedullin
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AREG amphiregulin
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BRD4 bromodomain containing 4
BTBD3 BTB (POZ) domain containing 3
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHERP calcium homeostasis endoplasmic reticulum protein
CLEC5A C-type lectin domain family 5, member A
CTGF connective tissue growth factor
CTSV cathepsin V
CUX1 cut-like homeobox 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DUSP4 dual specificity phosphatase 4
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EGR1 early growth response 1
EPCAM epithelial cell adhesion molecule
FNDC3B fibronectin type III domain containing 3B
FOSL2 FOS-like antigen 2
GATA3 GATA binding protein 3
GPC4 glypican 4
H1FX H1 histone family, member X
HES1 hes family bHLH transcription factor 1
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL1R2 interleukin 1 receptor, type II
IL6 interleukin 6
INSIG1 insulin induced gene 1
JAG1 jagged 1
JUN jun proto-oncogene
KANK1 KN motif and ankyrin repeat domains 1
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KLK11 kallikrein-related peptidase 11
LAMP3 lysosomal-associated membrane protein 3
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MTA1 metastasis associated 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
PDLIM5 PDZ and LIM domain 5
PLAUR plasminogen activator, urokinase receptor
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RBP4 retinol binding protein 4, plasma
RGCC regulator of cell cycle
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP1 secreted frizzled-related protein 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SOX17 SRY (sex determining region Y)-box 17
SOX4 SRY (sex determining region Y)-box 4
SPEN spen family transcriptional repressor
TACSTD2 tumor-associated calcium signal transducer 2
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM259 transmembrane protein 259
TPM4 tropomyosin 4
TSC22D1 TSC22 domain family, member 1
TSKU tsukushi, small leucine rich proteoglycan
WEE1 WEE1 G2 checkpoint kinase
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AHNAK2 AHNAK nucleoprotein 2
AIM1 absent in melanoma 1
AMZ2 archaelysin family metallopeptidase 2
ANXA4 annexin A4
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
BLNK B-cell linker
C6ORF62 chromosome 6 open reading frame 62
CBR3 carbonyl reductase 3
CCDC53 coiled-coil domain containing 53
CCNF cyclin F
CPE carboxypeptidase E
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF5 eukaryotic translation initiation factor 5
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPM6B glycoprotein M6B
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGHD immunoglobulin heavy constant delta
LONP2 lon peptidase 2, peroxisomal
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MAT2A methionine adenosyltransferase II, alpha
METTL13 methyltransferase like 13
MGP matrix Gla protein
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
PDE4B phosphodiesterase 4B, cAMP-specific
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PWP1 PWP1 homolog (S. cerevisiae)
RECQL RecQ helicase-like
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SGCE sarcoglycan, epsilon
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SPATS2L spermatogenesis associated, serine-rich 2-like
SPINK1 serine peptidase inhibitor, Kazal type 1
SRPX sushi-repeat containing protein, X-linked
STAMBP STAM binding protein
THYN1 thymocyte nuclear protein 1
TMEM176B transmembrane protein 176B
TPBG trophoblast glycoprotein
TSEN2 TSEN2 tRNA splicing endonuclease subunit
USO1 USO1 vesicle transport factor
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VCAM1 vascular cell adhesion molecule 1
XBP1 X-box binding protein 1
ZBTB20 zinc finger and BTB domain containing 20
ZNF185 zinc finger protein 185 (LIM domain)
Funding