BRD-A45498368_WYE-125132_A549_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

257 genes differentially expressed following the BRD-A45498368_WYE-125132_A549_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
AMDHD2 amidohydrolase domain containing 2
ANXA3 annexin A3
ANXA4 annexin A4
BCL2L1 BCL2-like 1
BEX1 brain expressed, X-linked 1
BHLHE41 basic helix-loop-helix family, member e41
CADM1 cell adhesion molecule 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAMLG calcium modulating ligand
CAPN2 calpain 2, (m/II) large subunit
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CGA glycoprotein hormones, alpha polypeptide
CIRBP cold inducible RNA binding protein
CTSD cathepsin D
CYFIP2 cytoplasmic FMR1 interacting protein 2
DFNA5 deafness, autosomal dominant 5
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EGFR epidermal growth factor receptor
EPAS1 endothelial PAS domain protein 1
EPCAM epithelial cell adhesion molecule
F13A1 coagulation factor XIII, A1 polypeptide
FBN1 fibrillin 1
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO3 forkhead box O3
GALC galactosylceramidase
GATAD1 GATA zinc finger domain containing 1
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8H golgin A8 family, member H
GPR137B G protein-coupled receptor 137B
GRN granulin
GSE1 Gse1 coiled-coil protein
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDS iduronate 2-sulfatase
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF1R insulin-like growth factor 1 receptor
IGF2R insulin-like growth factor 2 receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGB4 integrin, beta 4
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JADE2 jade family PHD finger 2
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIF5C kinesin family member 5C
KLF6 Kruppel-like factor 6
KRT7 keratin 7, type II
LAMC2 laminin, gamma 2
LETMD1 LETM1 domain containing 1
LGALS3 lectin, galactoside-binding, soluble, 3
LOC399491
LOX lysyl oxidase
LRPPRC leucine-rich pentatricopeptide repeat containing
LTBP1 latent transforming growth factor beta binding protein 1
LTBP3 latent transforming growth factor beta binding protein 3
LXN latexin
LY75 lymphocyte antigen 75
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MARCKS myristoylated alanine-rich protein kinase C substrate
MET MET proto-oncogene, receptor tyrosine kinase
MNT MAX network transcriptional repressor
MTMR11 myotubularin related protein 11
MTSS1 metastasis suppressor 1
MXI1 MAX interactor 1, dimerization protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NOV nephroblastoma overexpressed
NPC1 Niemann-Pick disease, type C1
NT5E 5'-nucleotidase, ecto (CD73)
OPTN optineurin
PARP6 poly (ADP-ribose) polymerase family, member 6
PDGFC platelet derived growth factor C
PGLS 6-phosphogluconolactonase
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLCB4 phospholipase C, beta 4
PLIN2 perilipin 2
RAB32 RAB32, member RAS oncogene family
RBKS ribokinase
RBM34 RNA binding motif protein 34
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIOK3 RIO kinase 3
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RSL1D1 ribosomal L1 domain containing 1
SCG2 secretogranin II
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SH3YL1 SH3 and SYLF domain containing 1
SLC16A6 solute carrier family 16, member 6
SOX4 SRY (sex determining region Y)-box 4
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STEAP3 STEAP family member 3, metalloreductase
STX1A syntaxin 1A (brain)
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TPP1 tripeptidyl peptidase I
TRAPPC6A trafficking protein particle complex 6A
TTC37 tetratricopeptide repeat domain 37
TXNIP thioredoxin interacting protein
USE1 unconventional SNARE in the ER 1 homolog (S. cerevisiae)
VAT1 vesicle amine transport 1
VDAC1 voltage-dependent anion channel 1
VWF von Willebrand factor
WDR45 WD repeat domain 45
ZBTB38 zinc finger and BTB domain containing 38

decreased expression

Symbol Name
AQP3 aquaporin 3 (Gill blood group)
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C20ORF24 chromosome 20 open reading frame 24
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CNN3 calponin 3, acidic
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
DHCR24 24-dehydrocholesterol reductase
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DONSON downstream neighbor of SON
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
E2F8 E2F transcription factor 8
ECT2 epithelial cell transforming 2
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EMP2 epithelial membrane protein 2
EXO1 exonuclease 1
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GBP1 guanylate binding protein 1, interferon-inducible
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GINS4 GINS complex subunit 4 (Sld5 homolog)
GMNN geminin, DNA replication inhibitor
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HAT1 histone acetyltransferase 1
HELLS helicase, lymphoid-specific
HJURP Holliday junction recognition protein
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IGL immunoglobulin lambda locus
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITM2A integral membrane protein 2A
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MTF2 metal response element binding transcription factor 2
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NREP neuronal regeneration related protein
NTS neurotensin
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
ORC6 origin recognition complex, subunit 6
PBK PDZ binding kinase
PEA15 phosphoprotein enriched in astrocytes 15
PHGDH phosphoglycerate dehydrogenase
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RAD51C RAD51 paralog C
RAD54B RAD54 homolog B (S. cerevisiae)
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RNASEH2A ribonuclease H2, subunit A
RPA3 replication protein A3, 14kDa
RRM2 ribonucleotide reductase M2
SDC2 syndecan 2
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SMCO4 single-pass membrane protein with coiled-coil domains 4
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TCL1A T-cell leukemia/lymphoma 1A
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TLR4 toll-like receptor 4
TMEM47 transmembrane protein 47
TMPO thymopoietin
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TSPAN13 tetraspanin 13
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
VRK1 vaccinia related kinase 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein
Funding