BRD-A45498368_WYE-125132_BT20_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

245 genes differentially expressed following the BRD-A45498368_WYE-125132_BT20_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARMCX1 armadillo repeat containing, X-linked 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BACE2 beta-site APP-cleaving enzyme 2
BCAS1 breast carcinoma amplified sequence 1
BEX1 brain expressed, X-linked 1
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C1RL complement component 1, r subcomponent-like
C6ORF62 chromosome 6 open reading frame 62
CALCOCO1 calcium binding and coiled-coil domain 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAST calpastatin
CBX7 chromobox homolog 7
CCDC28A coiled-coil domain containing 28A
CCNG2 cyclin G2
CD46 CD46 molecule, complement regulatory protein
CD59 CD59 molecule, complement regulatory protein
CDK19 cyclin-dependent kinase 19
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHN2 chimerin 2
CIRBP cold inducible RNA binding protein
CREBL2 cAMP responsive element binding protein-like 2
CTGF connective tissue growth factor
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DARS aspartyl-tRNA synthetase
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EFNA1 ephrin-A1
EIF4B eukaryotic translation initiation factor 4B
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
EXPH5 exophilin 5
F13A1 coagulation factor XIII, A1 polypeptide
FAM63A family with sequence similarity 63, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FGFR2 fibroblast growth factor receptor 2
FN1 fibronectin 1
FRZB frizzled-related protein
GAA glucosidase, alpha; acid
GABARAPL1 GABA(A) receptor-associated protein like 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45B growth arrest and DNA-damage-inducible, beta
GCC2 GRIP and coiled-coil domain containing 2
GDF15 growth differentiation factor 15
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLUL glutamate-ammonia ligase
GPM6B glycoprotein M6B
GPR137B G protein-coupled receptor 137B
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRB7 growth factor receptor-bound protein 7
GRN granulin
HBP1 HMG-box transcription factor 1
HCLS1 hematopoietic cell-specific Lyn substrate 1
HDAC5 histone deacetylase 5
HECA headcase homolog (Drosophila)
HMOX1 heme oxygenase 1
HNMT histamine N-methyltransferase
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFITM1 interferon induced transmembrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
IRS2 insulin receptor substrate 2
JMJD1C jumonji domain containing 1C
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDM5A lysine (K)-specific demethylase 5A
KIAA0355 KIAA0355
KLHDC2 kelch domain containing 2
KLHL24 kelch-like family member 24
KRT23 keratin 23, type I
LAMP2 lysosomal-associated membrane protein 2
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS8 lectin, galactoside-binding, soluble, 8
LXN latexin
LY75 lymphocyte antigen 75
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K5 mitogen-activated protein kinase kinase 5
MBNL2 muscleblind-like splicing regulator 2
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MVP major vault protein
MXRA7 matrix-remodelling associated 7
NBR1 neighbor of BRCA1 gene 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NUPR1 nuclear protein, transcriptional regulator, 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLIN2 perilipin 2
PNRC1 proline-rich nuclear receptor coactivator 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRSS8 protease, serine, 8
PSAP prosaposin
PSD3 pleckstrin and Sec7 domain containing 3
PYCARD PYD and CARD domain containing
RAB13 RAB13, member RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RB1CC1 RB1-inducible coiled-coil 1
RBM47 RNA binding motif protein 47
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASET2 ribonuclease T2
RND3 Rho family GTPase 3
RNMT RNA (guanine-7-) methyltransferase
RPS27L ribosomal protein S27-like
RTN2 reticulon 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SATB1 SATB homeobox 1
SDCBP syndecan binding protein (syntenin)
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SEPP1 selenoprotein P, plasma, 1
SERINC1 serine incorporator 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SH3YL1 SH3 and SYLF domain containing 1
SMAD3 SMAD family member 3
SORBS2 sorbin and SH3 domain containing 2
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SQSTM1 sequestosome 1
SRGN serglycin
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYT1 synaptotagmin I
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR3 transforming growth factor, beta receptor III
THBS1 thrombospondin 1
TIMP2 TIMP metallopeptidase inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM59 transmembrane protein 59
TPP1 tripeptidyl peptidase I
TRAM1 translocation associated membrane protein 1
TSPAN4 tetraspanin 4
TUFT1 tuftelin 1
UBE2B ubiquitin-conjugating enzyme E2B
VAT1 vesicle amine transport 1
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
WDTC1 WD and tetratricopeptide repeats 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
BAG2 BCL2-associated athanogene 2
BAMBI BMP and activin membrane-bound inhibitor
BMP7 bone morphogenetic protein 7
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BZW2 basic leucine zipper and W2 domains 2
C1QBP complement component 1, q subcomponent binding protein
CCND3 cyclin D3
CD36 CD36 molecule (thrombospondin receptor)
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSTA cystatin A (stefin A)
CYCS cytochrome c, somatic
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DKC1 dyskeratosis congenita 1, dyskerin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ELOVL6 ELOVL fatty acid elongase 6
ENO1 enolase 1, (alpha)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FEN1 flap structure-specific endonuclease 1
FGFBP1 fibroblast growth factor binding protein 1
G0S2 G0/G1 switch 2
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GSTM3 glutathione S-transferase mu 3 (brain)
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HSPA1A heat shock 70kDa protein 1A
ICMT isoprenylcysteine carboxyl methyltransferase
IGFBP5 insulin-like growth factor binding protein 5
IL1RN interleukin 1 receptor antagonist
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITM2A integral membrane protein 2A
LAP3 leucine aminopeptidase 3
LRRC59 leucine rich repeat containing 59
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MMP12 matrix metallopeptidase 12
MRPL12 mitochondrial ribosomal protein L12
MRPL17 mitochondrial ribosomal protein L17
MRPL3 mitochondrial ribosomal protein L3
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP56 NOP56 ribonucleoprotein
NRG1 neuregulin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCDH7 protocadherin 7
PCDH9 protocadherin 9
PCNA proliferating cell nuclear antigen
PDE10A phosphodiesterase 10A
PDLIM3 PDZ and LIM domain 3
PGM1 phosphoglucomutase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNP purine nucleoside phosphorylase
PPARG peroxisome proliferator-activated receptor gamma
PRDX2 peroxiredoxin 2
PRMT1 protein arginine methyltransferase 1
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SFN stratifin
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SOBP sine oculis binding protein homolog (Drosophila)
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SRM spermidine synthase
SRPRB signal recognition particle receptor, B subunit
STRA13 stimulated by retinoic acid 13
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TIPIN TIMELESS interacting protein
TMEM47 transmembrane protein 47
TRIP13 thyroid hormone receptor interactor 13
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
Funding