BRD-A45498368_WYE-125132_HME1_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

117 genes differentially expressed following the BRD-A45498368_WYE-125132_HME1_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACKR3 atypical chemokine receptor 3
ADCK3 aarF domain containing kinase 3
AHNAK AHNAK nucleoprotein
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
C6ORF48 chromosome 6 open reading frame 48
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CEMIP cell migration inducing protein, hyaluronan binding
CLIC5 chloride intracellular channel 5
CTGF connective tissue growth factor
CTSK cathepsin K
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEPTOR DEP domain containing MTOR-interacting protein
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP4 dual specificity phosphatase 4
EFNB2 ephrin-B2
EGFR epidermal growth factor receptor
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF3E eukaryotic translation initiation factor 3, subunit E
EPHB2 EPH receptor B2
F13A1 coagulation factor XIII, A1 polypeptide
F2RL1 coagulation factor II (thrombin) receptor-like 1
FZD6 frizzled class receptor 6
GATA2 GATA binding protein 2
GRN granulin
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IL1B interleukin 1, beta
KLF2 Kruppel-like factor 2
KRT81 keratin 81, type II
LAMA3 laminin, alpha 3
LAMC2 laminin, gamma 2
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIMS1 LIM and senescent cell antigen-like domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MFAP5 microfibrillar associated protein 5
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MME membrane metallo-endopeptidase
NBR1 neighbor of BRCA1 gene 1
NOTCH1 notch 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAU plasminogen activator, urokinase
PLCB4 phospholipase C, beta 4
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RPL22 ribosomal protein L22
SFRP4 secreted frizzled-related protein 4
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TGFB2 transforming growth factor, beta 2
TWIST1 twist family bHLH transcription factor 1
VNN1 vanin 1
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
AQP3 aquaporin 3 (Gill blood group)
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CIT citron rho-interacting serine/threonine kinase
CKS2 CDC28 protein kinase regulatory subunit 2
CRABP2 cellular retinoic acid binding protein 2
DBF4 DBF4 zinc finger
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
EMP2 epithelial membrane protein 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOXM1 forkhead box M1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
MGP matrix Gla protein
MKI67 marker of proliferation Ki-67
MSMO1 methylsterol monooxygenase 1
NEBL nebulette
NPTX2 neuronal pentraxin II
NUSAP1 nucleolar and spindle associated protein 1
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKCB protein kinase C, beta
PSRC1 proline/serine-rich coiled-coil 1
PTN pleiotrophin
RACGAP1 Rac GTPase activating protein 1
RAD51C RAD51 paralog C
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RRM2 ribonucleotide reductase M2
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
STK17A serine/threonine kinase 17a
TNS1 tensin 1
TPX2 TPX2, microtubule-associated
UBE2S ubiquitin-conjugating enzyme E2S
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
Funding