BRD-A45498368_WYE-125132_HME1_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-A45498368_WYE-125132_HME1_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADAM10 ADAM metallopeptidase domain 10
ADGRG6 adhesion G protein-coupled receptor G6
ALOX5 arachidonate 5-lipoxygenase
AMIGO2 adhesion molecule with Ig-like domain 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF3 activating transcription factor 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CFD complement factor D (adipsin)
CHIC2 cysteine-rich hydrophobic domain 2
CHRDL1 chordin-like 1
CLEC2B C-type lectin domain family 2, member B
COL14A1 collagen, type XIV, alpha 1
CRYAB crystallin, alpha B
CTGF connective tissue growth factor
DACT1 dishevelled-binding antagonist of beta-catenin 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DOK5 docking protein 5
DUSP5 dual specificity phosphatase 5
EGFR epidermal growth factor receptor
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
GADD45B growth arrest and DNA-damage-inducible, beta
GAS6 growth arrest-specific 6
H1FX H1 histone family, member X
HBP1 HMG-box transcription factor 1
HMGB2 high mobility group box 2
ICAM1 intercellular adhesion molecule 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
IQGAP1 IQ motif containing GTPase activating protein 1
IRS2 insulin receptor substrate 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KLF2 Kruppel-like factor 2
KRT17 keratin 17, type I
LAMA3 laminin, alpha 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MYOF myoferlin
NAV3 neuron navigator 3
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
OSR2 odd-skipped related transciption factor 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG3 paternally expressed 3
PLAT plasminogen activator, tissue
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKD1 protein kinase D1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RPL22 ribosomal protein L22
SCGB2A2 secretoglobin, family 2A, member 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SF3B1 splicing factor 3b, subunit 1, 155kDa
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
TFPI2 tissue factor pathway inhibitor 2
TKTL1 transketolase-like 1
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
UGCG UDP-glucose ceramide glucosyltransferase

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
ALB albumin
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
C2CD2 C2 calcium-dependent domain containing 2
CDC25A cell division cycle 25A
CNN3 calponin 3, acidic
CP ceruloplasmin (ferroxidase)
DDIT4 DNA-damage-inducible transcript 4
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FASTKD5 FAST kinase domains 5
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GSTA1 glutathione S-transferase alpha 1
GSTP1 glutathione S-transferase pi 1
HOXB2 homeobox B2
HSPA1A heat shock 70kDa protein 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
KRT13 keratin 13, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LMO2 LIM domain only 2 (rhombotin-like 1)
MMP9 matrix metallopeptidase 9
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NOP16 NOP16 nucleolar protein
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SNAP25 synaptosomal-associated protein, 25kDa
SNX7 sorting nexin 7
SPRR3 small proline-rich protein 3
SRGN serglycin
TES testin LIM domain protein
TSPYL5 TSPY-like 5
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
Funding