BRD-A45498368_WYE-125132_HS578T_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

166 genes differentially expressed following the BRD-A45498368_WYE-125132_HS578T_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADIRF adipogenesis regulatory factor
ANGPTL2 angiopoietin-like 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CAMLG calcium modulating ligand
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCNA1 cyclin A1
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDK19 cyclin-dependent kinase 19
CEP68 centrosomal protein 68kDa
CIRBP cold inducible RNA binding protein
CLEC2B C-type lectin domain family 2, member B
COL6A1 collagen, type VI, alpha 1
COLEC11 collectin sub-family member 11
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
DCHS1 dachsous cadherin-related 1
DCN decorin
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLK1 delta-like 1 homolog (Drosophila)
DUSP3 dual specificity phosphatase 3
EMP1 epithelial membrane protein 1
F13A1 coagulation factor XIII, A1 polypeptide
F2R coagulation factor II (thrombin) receptor
FNBP1 formin binding protein 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GPC3 glypican 3
GPM6A glycoprotein M6A
GSE1 Gse1 coiled-coil protein
HIST3H2A histone cluster 3, H2a
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGBP1 immunoglobulin (CD79A) binding protein 1
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
KLHL21 kelch-like family member 21
LETMD1 LETM1 domain containing 1
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAMLD1 mastermind-like domain containing 1
MAST4 microtubule associated serine/threonine kinase family member 4
MYO6 myosin VI
NMRK1 nicotinamide riboside kinase 1
NPDC1 neural proliferation, differentiation and control, 1
NPTX2 neuronal pentraxin II
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PEG3 paternally expressed 3
RANBP9 RAN binding protein 9
RGCC regulator of cell cycle
RGS10 regulator of G-protein signaling 10
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC38A1 solute carrier family 38, member 1
SOX4 SRY (sex determining region Y)-box 4
STAB1 stabilin 1
STAR steroidogenic acute regulatory protein
STXBP2 syntaxin binding protein 2
TIMP3 TIMP metallopeptidase inhibitor 3
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TUBB2A tubulin, beta 2A class IIa
VAT1 vesicle amine transport 1
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
XIST X inactive specific transcript (non-protein coding)
ZFPM2 zinc finger protein, FOG family member 2
ZNF292 zinc finger protein 292
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AARS alanyl-tRNA synthetase
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ASCC3 activating signal cointegrator 1 complex subunit 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPH aspartate beta-hydroxylase
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C20ORF24 chromosome 20 open reading frame 24
CCDC86 coiled-coil domain containing 86
CCND3 cyclin D3
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK2 cyclin-dependent kinase 2
CENPU centromere protein U
CLIC3 chloride intracellular channel 3
CTSZ cathepsin Z
CYB5A cytochrome b5 type A (microsomal)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
FEN1 flap structure-specific endonuclease 1
FKBP14 FK506 binding protein 14, 22 kDa
FOLR1 folate receptor 1 (adult)
GBP1 guanylate binding protein 1, interferon-inducible
GCLM glutamate-cysteine ligase, modifier subunit
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GSTT1 glutathione S-transferase theta 1
HEG1 heart development protein with EGF-like domains 1
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
ICMT isoprenylcysteine carboxyl methyltransferase
IFI44L interferon-induced protein 44-like
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
KIAA0101 KIAA0101
LAPTM4B lysosomal protein transmembrane 4 beta
LRRC59 leucine rich repeat containing 59
MARS methionyl-tRNA synthetase
MATN2 matrilin 2
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYCBP MYC binding protein
NEFL neurofilament, light polypeptide
NME1 NME/NM23 nucleoside diphosphate kinase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCNA proliferating cell nuclear antigen
PCP4 Purkinje cell protein 4
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PEX11A peroxisomal biogenesis factor 11 alpha
PGAM1 phosphoglycerate mutase 1 (brain)
PHGDH phosphoglycerate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PLAC8 placenta-specific 8
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PSAT1 phosphoserine aminotransferase 1
RHOQ ras homolog family member Q
RPN2 ribophorin II
RRM2 ribonucleotide reductase M2
SDF2L1 stromal cell-derived factor 2-like 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMCO4 single-pass membrane protein with coiled-coil domains 4
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SQLE squalene epoxidase
STRA13 stimulated by retinoic acid 13
TARS threonyl-tRNA synthetase
TFF3 trefoil factor 3 (intestinal)
TIGAR TP53 induced glycolysis regulatory phosphatase
TIMELESS timeless circadian clock
TPD52 tumor protein D52
TYMS thymidylate synthetase
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
YARS tyrosyl-tRNA synthetase
ZWINT ZW10 interacting kinetochore protein
Funding