BRD-A45498368_WYE-125132_MCF10A_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

218 genes differentially expressed following the BRD-A45498368_WYE-125132_MCF10A_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADIRF adipogenesis regulatory factor
AHNAK AHNAK nucleoprotein
AMIGO2 adhesion molecule with Ig-like domain 2
APOD apolipoprotein D
AREG amphiregulin
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARMCX2 armadillo repeat containing, X-linked 2
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD99 CD99 molecule
CRIP1 cysteine-rich protein 1 (intestinal)
CYBRD1 cytochrome b reductase 1
CYTH1 cytohesin 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DPYSL2 dihydropyrimidinase-like 2
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNB2 ephrin-B2
EHD2 EH-domain containing 2
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF3L eukaryotic translation initiation factor 3, subunit L
EMP1 epithelial membrane protein 1
EPAS1 endothelial PAS domain protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
FADS3 fatty acid desaturase 3
FAM114A1 family with sequence similarity 114, member A1
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FSTL1 follistatin-like 1
FZD7 frizzled class receptor 7
GAS6 growth arrest-specific 6
GLTSCR2 glioma tumor suppressor candidate region gene 2
GM2A GM2 ganglioside activator
GPX3 glutathione peroxidase 3
GPX4 glutathione peroxidase 4
GSN gelsolin
HAPLN1 hyaluronan and proteoglycan link protein 1
HMGA2 high mobility group AT-hook 2
IDS iduronate 2-sulfatase
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGFBP7 insulin-like growth factor binding protein 7
IL1R1 interleukin 1 receptor, type I
IRS1 insulin receptor substrate 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGAV integrin, alpha V
ITGB4 integrin, beta 4
ITGB5 integrin, beta 5
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JAG1 jagged 1
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LAMA3 laminin, alpha 3
LAMB2 laminin, beta 2 (laminin S)
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LAPTM5 lysosomal protein transmembrane 5
LDOC1 leucine zipper, down-regulated in cancer 1
LEPROT leptin receptor overlapping transcript
LPAR1 lysophosphatidic acid receptor 1
LTBP2 latent transforming growth factor beta binding protein 2
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGED2 melanoma antigen family D2
MDK midkine (neurite growth-promoting factor 2)
MET MET proto-oncogene, receptor tyrosine kinase
MFAP5 microfibrillar associated protein 5
MME membrane metallo-endopeptidase
MSLN mesothelin
MTSS1 metastasis suppressor 1
MYL9 myosin, light chain 9, regulatory
NPC2 Niemann-Pick disease, type C2
NT5E 5'-nucleotidase, ecto (CD73)
OPTN optineurin
OXTR oxytocin receptor
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDLIM4 PDZ and LIM domain 4
PEX11A peroxisomal biogenesis factor 11 alpha
PGLS 6-phosphogluconolactonase
PLA2G16 phospholipase A2, group XVI
PLAU plasminogen activator, urokinase
PNRC1 proline-rich nuclear receptor coactivator 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPOX protoporphyrinogen oxidase
PTK2B protein tyrosine kinase 2 beta
PTPRE protein tyrosine phosphatase, receptor type, E
PXDN peroxidasin
RABAC1 Rab acceptor 1 (prenylated)
RRAS related RAS viral (r-ras) oncogene homolog
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC4 syndecan 4
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SOX4 SRY (sex determining region Y)-box 4
SPAG4 sperm associated antigen 4
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRPX sushi-repeat containing protein, X-linked
STC2 stanniocalcin 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TGM2 transglutaminase 2
THBS4 thrombospondin 4
TNIP1 TNFAIP3 interacting protein 1
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TRIM8 tripartite motif containing 8
TUBA1A tubulin, alpha 1a
VAMP8 vesicle-associated membrane protein 8
VAT1 vesicle amine transport 1
VCAN versican
VEGFC vascular endothelial growth factor C
WDR13 WD repeat domain 13
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
AQP3 aquaporin 3 (Gill blood group)
ATF5 activating transcription factor 5
AURKA aurora kinase A
BCLAF1 BCL2-associated transcription factor 1
BIRC5 baculoviral IAP repeat containing 5
BLMH bleomycin hydrolase
C3ORF14 chromosome 3 open reading frame 14
CCNA2 cyclin A2
CCNE2 cyclin E2
CCNF cyclin F
CD320 CD320 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CEP55 centrosomal protein 55kDa
CKS2 CDC28 protein kinase regulatory subunit 2
CRISP3 cysteine-rich secretory protein 3
CTPS1 CTP synthase 1
CXCL9 chemokine (C-X-C motif) ligand 9
CYCS cytochrome c, somatic
DBF4 DBF4 zinc finger
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DUOX2 dual oxidase 2
EXO1 exonuclease 1
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
GAL galanin/GMAP prepropeptide
GBP1 guanylate binding protein 1, interferon-inducible
GCH1 GTP cyclohydrolase 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNAS GNAS complex locus
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIF20A kinesin family member 20A
LAMP5 lysosomal-associated membrane protein family, member 5
LBR lamin B receptor
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAP7 microtubule-associated protein 7
MCM10 minichromosome maintenance complex component 10
MOCS2 molybdenum cofactor synthesis 2
MTCL1 microtubule crosslinking factor 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NUP98 nucleoporin 98kDa
OIP5 Opa interacting protein 5
PBK PDZ binding kinase
PCP4 Purkinje cell protein 4
PCSK1 proprotein convertase subtilisin/kexin type 1
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PHGDH phosphoglycerate dehydrogenase
PI3 peptidase inhibitor 3, skin-derived
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSAT1 phosphoserine aminotransferase 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAD51C RAD51 paralog C
RCAN2 regulator of calcineurin 2
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RFK riboflavin kinase
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRM1 ribonucleotide reductase M1
SCML1 sex comb on midleg-like 1 (Drosophila)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SNAP25 synaptosomal-associated protein, 25kDa
SPINK5 serine peptidase inhibitor, Kazal type 5
SRSF3 serine/arginine-rich splicing factor 3
SUB1 SUB1 homolog (S. cerevisiae)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TFAM transcription factor A, mitochondrial
TMEM97 transmembrane protein 97
TMPO thymopoietin
TOX3 TOX high mobility group box family member 3
TPD52 tumor protein D52
TRIP13 thyroid hormone receptor interactor 13
UBE2S ubiquitin-conjugating enzyme E2S
UNC13B unc-13 homolog B (C. elegans)
WARS tryptophanyl-tRNA synthetase
Funding