BRD-A45498368_WYE-125132_MCF10A_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

320 genes differentially expressed following the BRD-A45498368_WYE-125132_MCF10A_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADIRF adipogenesis regulatory factor
AHNAK AHNAK nucleoprotein
AHNAK2 AHNAK nucleoprotein 2
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA4 annexin A4
ANXA5 annexin A5
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP9A ATPase, class II, type 9A
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CAPN1 calpain 1, (mu/I) large subunit
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CDK19 cyclin-dependent kinase 19
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIRBP cold inducible RNA binding protein
CPM carboxypeptidase M
CRIP1 cysteine-rich protein 1 (intestinal)
CYTH1 cytohesin 1
DCN decorin
DHRS3 dehydrogenase/reductase (SDR family) member 3
DIAPH2 diaphanous-related formin 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DPYSL2 dihydropyrimidinase-like 2
DSP desmoplakin
ECHDC2 enoyl CoA hydratase domain containing 2
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
ELOVL4 ELOVL fatty acid elongase 4
EMP1 epithelial membrane protein 1
F13A1 coagulation factor XIII, A1 polypeptide
FABP4 fatty acid binding protein 4, adipocyte
FAM127A family with sequence similarity 127, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FHL1 four and a half LIM domains 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FN1 fibronectin 1
FXR1 fragile X mental retardation, autosomal homolog 1
GAA glucosidase, alpha; acid
GAS6 growth arrest-specific 6
GDI1 GDP dissociation inhibitor 1
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8A golgin A8 family, member A
GPX4 glutathione peroxidase 4
GRN granulin
GSN gelsolin
HBP1 HMG-box transcription factor 1
HMGA2 high mobility group AT-hook 2
HOOK2 hook microtubule-tethering protein 2
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGFBP3 insulin-like growth factor binding protein 3
IGFBP6 insulin-like growth factor binding protein 6
INHBA inhibin, beta A
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGB5 integrin, beta 5
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KIF2C kinesin family member 2C
KRT19 keratin 19, type I
LAMB2 laminin, beta 2 (laminin S)
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS3 lectin, galactoside-binding, soluble, 3
LOC399491
LTA4H leukotriene A4 hydrolase
LTBP3 latent transforming growth factor beta binding protein 3
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MET MET proto-oncogene, receptor tyrosine kinase
MFAP5 microfibrillar associated protein 5
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MGLL monoglyceride lipase
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MME membrane metallo-endopeptidase
MTSS1 metastasis suppressor 1
MUC1 mucin 1, cell surface associated
MVP major vault protein
MYL9 myosin, light chain 9, regulatory
N4BP2L2 NEDD4 binding protein 2-like 2
NDRG1 N-myc downstream regulated 1
NOTCH2NL notch 2 N-terminal like
NPC1 Niemann-Pick disease, type C1
NPIPB3 nuclear pore complex interacting protein family, member B3
NRIP1 nuclear receptor interacting protein 1
NT5E 5'-nucleotidase, ecto (CD73)
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
PDGFC platelet derived growth factor C
PGLS 6-phosphogluconolactonase
PLBD1 phospholipase B domain containing 1
PNRC1 proline-rich nuclear receptor coactivator 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPL periplakin
PRAF2 PRA1 domain family, member 2
PROS1 protein S (alpha)
PRSS8 protease, serine, 8
PSAP prosaposin
PXDN peroxidasin
RABAC1 Rab acceptor 1 (prenylated)
RBKS ribokinase
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAS related RAS viral (r-ras) oncogene homolog
RSRP1 arginine/serine-rich protein 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC22A18 solute carrier family 22, member 18
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOD2 superoxide dismutase 2, mitochondrial
SOS2 son of sevenless homolog 2 (Drosophila)
SOX4 SRY (sex determining region Y)-box 4
SPINT1 serine peptidase inhibitor, Kunitz type 1
SQSTM1 sequestosome 1
SSPN sarcospan
SULF1 sulfatase 1
SYT17 synaptotagmin XVII
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMP2 TIMP metallopeptidase inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TNIP1 TNFAIP3 interacting protein 1
TNS3 tensin 3
TP53I3 tumor protein p53 inducible protein 3
TPP1 tripeptidyl peptidase I
TRIB1 tribbles pseudokinase 1
TRIM8 tripartite motif containing 8
TSC22D3 TSC22 domain family, member 3
TSPAN31 tetraspanin 31
TUBA1A tubulin, alpha 1a
USP9X ubiquitin specific peptidase 9, X-linked
VAT1 vesicle amine transport 1
VCAN versican
VNN1 vanin 1
WDR13 WD repeat domain 13
WDR45 WD repeat domain 45
WNK1 WNK lysine deficient protein kinase 1
YPEL5 yippee-like 5 (Drosophila)
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZC2HC1A zinc finger, C2HC-type containing 1A
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARG2 arginase 2
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
AUNIP aurora kinase A and ninein interacting protein
AURKA aurora kinase A
AURKB aurora kinase B
BAG2 BCL2-associated athanogene 2
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CCNF cyclin F
CD3EAP CD3e molecule, epsilon associated protein
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CKS1B CDC28 protein kinase regulatory subunit 1B
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL8 chemokine (C-X-C motif) ligand 8
DBF4 DBF4 zinc finger
DDIT4 DNA-damage-inducible transcript 4
DEPDC1 DEP domain containing 1
DHFR dihydrofolate reductase
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DONSON downstream neighbor of SON
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FANCG Fanconi anemia, complementation group G
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FOXM1 forkhead box M1
GAL galanin/GMAP prepropeptide
GBP1 guanylate binding protein 1, interferon-inducible
GCH1 GTP cyclohydrolase 1
GGCT gamma-glutamylcyclotransferase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GMNN geminin, DNA replication inhibitor
GOLM1 golgi membrane protein 1
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HAT1 histone acetyltransferase 1
HMGB2 high mobility group box 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA4L heat shock 70kDa protein 4-like
ICMT isoprenylcysteine carboxyl methyltransferase
IFI44 interferon-induced protein 44
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KIAA0101 KIAA0101
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LMNB2 lamin B2
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MEIS2 Meis homeobox 2
MELK maternal embryonic leucine zipper kinase
MLEC malectin
MOCS2 molybdenum cofactor synthesis 2
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NDC1 NDC1 transmembrane nucleoporin
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NFIB nuclear factor I/B
NLRP2 NLR family, pyrin domain containing 2
NOP56 NOP56 ribonucleoprotein
NPY neuropeptide Y
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PA2G4 proliferation-associated 2G4, 38kDa
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDIA4 protein disulfide isomerase family A, member 4
PFAS phosphoribosylformylglycinamidine synthase
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRPF4 pre-mRNA processing factor 4
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PSRC1 proline/serine-rich coiled-coil 1
RACGAP1 Rac GTPase activating protein 1
RAD51 RAD51 recombinase
RAD51C RAD51 paralog C
RAD54L RAD54-like (S. cerevisiae)
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RMI1 RecQ mediated genome instability 1
RPA2 replication protein A2, 32kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SCGB2A1 secretoglobin, family 2A, member 1
SCML1 sex comb on midleg-like 1 (Drosophila)
SDF2L1 stromal cell-derived factor 2-like 1
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC25A46 solute carrier family 25, member 46
SMC1A structural maintenance of chromosomes 1A
SNAP25 synaptosomal-associated protein, 25kDa
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SORD sorbitol dehydrogenase
SPC25 SPC25, NDC80 kinetochore complex component
SRM spermidine synthase
SUB1 SUB1 homolog (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TFDP1 transcription factor Dp-1
TIMELESS timeless circadian clock
TIPIN TIMELESS interacting protein
TK1 thymidine kinase 1, soluble
TMEM194A transmembrane protein 194A
TMEM97 transmembrane protein 97
TMPO thymopoietin
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TSPAN8 tetraspanin 8
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
UMPS uridine monophosphate synthetase
VRK1 vaccinia related kinase 1
WARS tryptophanyl-tRNA synthetase
ZWINT ZW10 interacting kinetochore protein
Funding