BRD-A45498368_WYE-125132_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

238 genes differentially expressed following the BRD-A45498368_WYE-125132_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADGRG6 adhesion G protein-coupled receptor G6
AGR2 anterior gradient 2
AHNAK2 AHNAK nucleoprotein 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMOTL2 angiomotin like 2
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
ATP9A ATPase, class II, type 9A
C6ORF48 chromosome 6 open reading frame 48
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD24 CD24 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHMP4A charged multivesicular body protein 4A
CIRBP cold inducible RNA binding protein
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRIP1 cysteine-rich protein 1 (intestinal)
CTGF connective tissue growth factor
CTSA cathepsin A
CTSD cathepsin D
CYBRD1 cytochrome b reductase 1
CYR61 cysteine-rich, angiogenic inducer, 61
DEPTOR DEP domain containing MTOR-interacting protein
DHRS3 dehydrogenase/reductase (SDR family) member 3
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40
DUSP4 dual specificity phosphatase 4
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
EHD2 EH-domain containing 2
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF4B eukaryotic translation initiation factor 4B
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
EPCAM epithelial cell adhesion molecule
ERBB2 erb-b2 receptor tyrosine kinase 2
ERGIC3 ERGIC and golgi 3
FABP4 fatty acid binding protein 4, adipocyte
FAXDC2 fatty acid hydroxylase domain containing 2
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FXR1 fragile X mental retardation, autosomal homolog 1
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GOLGA8H golgin A8 family, member H
GOLGB1 golgin B1
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
HBP1 HMG-box transcription factor 1
HEXA hexosaminidase A (alpha polypeptide)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST3H2A histone cluster 3, H2a
HLA-E major histocompatibility complex, class I, E
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPG2 heparan sulfate proteoglycan 2
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IGBP1 immunoglobulin (CD79A) binding protein 1
IGFBP6 insulin-like growth factor binding protein 6
IGFBP7 insulin-like growth factor binding protein 7
IRS2 insulin receptor substrate 2
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LAMA3 laminin, alpha 3
LAMB2 laminin, beta 2 (laminin S)
LAMC1 laminin, gamma 1 (formerly LAMB2)
LDOC1 leucine zipper, down-regulated in cancer 1
LEPR leptin receptor
LEPROT leptin receptor overlapping transcript
LETMD1 LETM1 domain containing 1
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS4 lectin, galactoside-binding, soluble, 4
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOA monoamine oxidase A
MET MET proto-oncogene, receptor tyrosine kinase
METRN meteorin, glial cell differentiation regulator
MFAP5 microfibrillar associated protein 5
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MGLL monoglyceride lipase
MLPH melanophilin
MVP major vault protein
MXRA7 matrix-remodelling associated 7
MYL9 myosin, light chain 9, regulatory
MYOF myoferlin
N4BP2L2 NEDD4 binding protein 2-like 2
NET1 neuroepithelial cell transforming 1
NPEPL1 aminopeptidase-like 1
NT5E 5'-nucleotidase, ecto (CD73)
OSBPL1A oxysterol binding protein-like 1A
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDGFC platelet derived growth factor C
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDLIM5 PDZ and LIM domain 5
PLA2G16 phospholipase A2, group XVI
PLIN2 perilipin 2
PLK2 polo-like kinase 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PROM1 prominin 1
PRSS23 protease, serine, 23
PTCH1 patched 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
PXDC1 PX domain containing 1
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RBKS ribokinase
RND3 Rho family GTPase 3
RRAGC Ras-related GTP binding C
S100P S100 calcium binding protein P
SCGB1D2 secretoglobin, family 1D, member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP4 secreted frizzled-related protein 4
SLC16A6 solute carrier family 16, member 6
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SQSTM1 sequestosome 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TCTN1 tectonic family member 1
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TPP1 tripeptidyl peptidase I
TRAPPC6A trafficking protein particle complex 6A
TSPAN1 tetraspanin 1
TSPAN31 tetraspanin 31
TSPAN4 tetraspanin 4
TXNIP thioredoxin interacting protein
UGCG UDP-glucose ceramide glucosyltransferase
VAT1 vesicle amine transport 1
VEGFC vascular endothelial growth factor C
VNN1 vanin 1
VWF von Willebrand factor
XIST X inactive specific transcript (non-protein coding)
ZNF586 zinc finger protein 586
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
AKAP7 A kinase (PRKA) anchor protein 7
ARG2 arginase 2
ATAD2 ATPase family, AAA domain containing 2
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CCL20 chemokine (C-C motif) ligand 20
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CENPU centromere protein U
COTL1 coactosin-like F-actin binding protein 1
CSTA cystatin A (stefin A)
CYB5A cytochrome b5 type A (microsomal)
CYCS cytochrome c, somatic
DBF4 DBF4 zinc finger
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF5A eukaryotic translation initiation factor 5A
ELOVL6 ELOVL fatty acid elongase 6
FADS1 fatty acid desaturase 1
FEN1 flap structure-specific endonuclease 1
GBP1 guanylate binding protein 1, interferon-inducible
GCH1 GTP cyclohydrolase 1
GGCT gamma-glutamylcyclotransferase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
HAT1 histone acetyltransferase 1
HSPA14 heat shock 70kDa protein 14
ICMT isoprenylcysteine carboxyl methyltransferase
IGHM immunoglobulin heavy constant mu
IL1RN interleukin 1 receptor antagonist
INSIG1 insulin induced gene 1
LMNB1 lamin B1
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MARS methionyl-tRNA synthetase
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPD3 non-SMC condensin II complex, subunit D3
NREP neuronal regeneration related protein
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PGK1 phosphoglycerate kinase 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PSPH phosphoserine phosphatase
RFC3 replication factor C (activator 1) 3, 38kDa
RMI1 RecQ mediated genome instability 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SESN1 sestrin 1
SFN stratifin
SH2B3 SH2B adaptor protein 3
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMCO4 single-pass membrane protein with coiled-coil domains 4
SNRPA1 small nuclear ribonucleoprotein polypeptide A'
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SRSF7 serine/arginine-rich splicing factor 7
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein
SUB1 SUB1 homolog (S. cerevisiae)
TF transferrin
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFDP1 transcription factor Dp-1
TIGAR TP53 induced glycolysis regulatory phosphatase
TK1 thymidine kinase 1, soluble
TMEM97 transmembrane protein 97
TMPO thymopoietin
TRIP13 thyroid hormone receptor interactor 13
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
VRK1 vaccinia related kinase 1
VSNL1 visinin-like 1
Funding