BRD-A45498368_WYE-125132_SKBR3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

232 genes differentially expressed following the BRD-A45498368_WYE-125132_SKBR3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
AGR2 anterior gradient 2
AKR1C3 aldo-keto reductase family 1, member C3
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA4 annexin A4
ATP9A ATPase, class II, type 9A
BDKRB2 bradykinin receptor B2
C6ORF48 chromosome 6 open reading frame 48
CA12 carbonic anhydrase XII
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD99 CD99 molecule
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CIRBP cold inducible RNA binding protein
CRISP3 cysteine-rich secretory protein 3
CST1 cystatin SN
CYTH1 cytohesin 1
DAPK1 death-associated protein kinase 1
DSG2 desmoglein 2
EFNA1 ephrin-A1
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF3E eukaryotic translation initiation factor 3, subunit E
EIF3L eukaryotic translation initiation factor 3, subunit L
EIF4B eukaryotic translation initiation factor 4B
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FOXO3 forkhead box O3
FXR1 fragile X mental retardation, autosomal homolog 1
FXYD3 FXYD domain containing ion transport regulator 3
GALC galactosylceramidase
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GATA6 GATA binding protein 6
GCC2 GRIP and coiled-coil domain containing 2
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GLTSCR2 glioma tumor suppressor candidate region gene 2
GRB10 growth factor receptor-bound protein 10
GRB7 growth factor receptor-bound protein 7
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRS1 insulin receptor substrate 1
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF6 Kruppel-like factor 6
KLHDC2 kelch domain containing 2
KRT19 keratin 19, type I
LETMD1 LETM1 domain containing 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGALS9 lectin, galactoside-binding, soluble, 9
LRPPRC leucine-rich pentatricopeptide repeat containing
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN2A1 mannosidase, alpha, class 2A, member 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MBNL2 muscleblind-like splicing regulator 2
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MTUS1 microtubule associated tumor suppressor 1
MVP major vault protein
MYRF myelin regulatory factor
NAP1L1 nucleosome assembly protein 1-like 1
NBR1 neighbor of BRCA1 gene 1
NCK2 NCK adaptor protein 2
NDRG1 N-myc downstream regulated 1
NMI N-myc (and STAT) interactor
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae)
OPTN optineurin
PGLS 6-phosphogluconolactonase
PHLDA1 pleckstrin homology-like domain, family A, member 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PRKCH protein kinase C, eta
PTX3 pentraxin 3, long
QARS glutaminyl-tRNA synthetase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAP1GAP RAP1 GTPase activating protein
REEP5 receptor accessory protein 5
RGS10 regulator of G-protein signaling 10
RND3 Rho family GTPase 3
RPL14 ribosomal protein L14
RPL36 ribosomal protein L36
RPS9 ribosomal protein S9
RSL1D1 ribosomal L1 domain containing 1
RSL24D1 ribosomal L24 domain containing 1
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SERINC1 serine incorporator 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SH3BP4 SH3-domain binding protein 4
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SYNJ2 synaptojanin 2
TANK TRAF family member-associated NFKB activator
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TRAF5 TNF receptor-associated factor 5
TRIB1 tribbles pseudokinase 1
TRIM22 tripartite motif containing 22
TXNL4B thioredoxin-like 4B
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZNF277 zinc finger protein 277
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACSL4 acyl-CoA synthetase long-chain family member 4
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALB albumin
ALDOC aldolase C, fructose-bisphosphate
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOH apolipoprotein H (beta-2-glycoprotein I)
ARG2 arginase 2
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AURKA aurora kinase A
BAG2 BCL2-associated athanogene 2
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
C3 complement component 3
C4BPA complement component 4 binding protein, alpha
CALR calreticulin
CCNA2 cyclin A2
CCND3 cyclin D3
CCR2 chemokine (C-C motif) receptor 2
CDC25A cell division cycle 25A
CDC7 cell division cycle 7
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CIT citron rho-interacting serine/threonine kinase
CXCL9 chemokine (C-X-C motif) ligand 9
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCXR dicarbonyl/L-xylulose reductase
DEGS1 delta(4)-desaturase, sphingolipid 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DUSP2 dual specificity phosphatase 2
EBP emopamil binding protein (sterol isomerase)
EFS embryonal Fyn-associated substrate
FADS2 fatty acid desaturase 2
FEN1 flap structure-specific endonuclease 1
FOLR1 folate receptor 1 (adult)
FOXM1 forkhead box M1
FRZB frizzled-related protein
GAL galanin/GMAP prepropeptide
GNAS GNAS complex locus
GZMK granzyme K (granzyme 3; tryptase II)
HACD3 3-hydroxyacyl-CoA dehydratase 3
HBB hemoglobin, beta
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HRASLS HRAS-like suppressor
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA1A heat shock 70kDa protein 1A
HSPH1 heat shock 105kDa/110kDa protein 1
ICMT isoprenylcysteine carboxyl methyltransferase
IGHD immunoglobulin heavy constant delta
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
JCHAIN joining chain of multimeric IgA and IgM
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT5 keratin 5, type II
LAGE3 L antigen family, member 3
LBR lamin B receptor
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTF lactotransferrin
LUM lumican
MAOB monoamine oxidase B
MLEC malectin
MSMO1 methylsterol monooxygenase 1
MTCH2 mitochondrial carrier 2
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
PCCB propionyl CoA carboxylase, beta polypeptide
PHGDH phosphoglycerate dehydrogenase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLK1 polo-like kinase 1
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTGDS prostaglandin D2 synthase 21kDa (brain)
REEP1 receptor accessory protein 1
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC1 syndecan 1
SDF2L1 stromal cell-derived factor 2-like 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFTPD surfactant protein D
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLPI secretory leukocyte peptidase inhibitor
SRM spermidine synthase
SUB1 SUB1 homolog (S. cerevisiae)
TCL1A T-cell leukemia/lymphoma 1A
TMEM45A transmembrane protein 45A
TNC tenascin C
TRIP13 thyroid hormone receptor interactor 13
TUBG1 tubulin, gamma 1
UBE2S ubiquitin-conjugating enzyme E2S
WT1 Wilms tumor 1
ZWINT ZW10 interacting kinetochore protein
Funding