BRD-A45498368_WYE-125132_SKBR3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

269 genes differentially expressed following the BRD-A45498368_WYE-125132_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADAM28 ADAM metallopeptidase domain 28
AGR2 anterior gradient 2
BCL2L1 BCL2-like 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C6ORF48 chromosome 6 open reading frame 48
CAST calpastatin
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBR3 carbonyl reductase 3
CCNG1 cyclin G1
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK7 cyclin-dependent kinase 7
CIRBP cold inducible RNA binding protein
CLDN4 claudin 4
CPD carboxypeptidase D
CST1 cystatin SN
CTSL cathepsin L
CYTH1 cytohesin 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DSG2 desmoglein 2
DUSP14 dual specificity phosphatase 14
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF3L eukaryotic translation initiation factor 3, subunit L
EIF4B eukaryotic translation initiation factor 4B
EIF5A eukaryotic translation initiation factor 5A
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EXOC1 exocyst complex component 1
FOXO3 forkhead box O3
FXR1 fragile X mental retardation, autosomal homolog 1
FXYD3 FXYD domain containing ion transport regulator 3
FZD5 frizzled class receptor 5
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GCC2 GRIP and coiled-coil domain containing 2
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GLTSCR2 glioma tumor suppressor candidate region gene 2
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRB7 growth factor receptor-bound protein 7
HBP1 HMG-box transcription factor 1
HEBP1 heme binding protein 1
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
IGBP1 immunoglobulin (CD79A) binding protein 1
IL18 interleukin 18
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGAV integrin, alpha V
ITGB5 integrin, beta 5
KLHDC2 kelch domain containing 2
KRT18 keratin 18, type I
LETMD1 LETM1 domain containing 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN2A1 mannosidase, alpha, class 2A, member 1
MBNL2 muscleblind-like splicing regulator 2
MLPH melanophilin
MXI1 MAX interactor 1, dimerization protein
N4BP2L2 NEDD4 binding protein 2-like 2
NBR1 neighbor of BRCA1 gene 1
NCK2 NCK adaptor protein 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NOTCH2NL notch 2 N-terminal like
NRIP1 nuclear receptor interacting protein 1
OBSL1 obscurin-like 1
PDLIM5 PDZ and LIM domain 5
PNRC1 proline-rich nuclear receptor coactivator 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PRSS8 protease, serine, 8
PTEN phosphatase and tensin homolog
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB13 RAB13, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
REEP5 receptor accessory protein 5
RGS10 regulator of G-protein signaling 10
RIOK3 RIO kinase 3
RTN2 reticulon 2
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A1 secretoglobin, family 2A, member 1
SECISBP2L SECIS binding protein 2-like
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC22A18 solute carrier family 22, member 18
SMAD3 SMAD family member 3
SNAP25 synaptosomal-associated protein, 25kDa
SP100 SP100 nuclear antigen
STXBP2 syntaxin binding protein 2
SVIL supervillin
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYT1 synaptotagmin I
SYT17 synaptotagmin XVII
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TIMP2 TIMP metallopeptidase inhibitor 2
TNNT1 troponin T type 1 (skeletal, slow)
TNS3 tensin 3
TOM1L1 target of myb1 (chicken)-like 1
TSPAN4 tetraspanin 4
TUG1 taurine up-regulated 1 (non-protein coding)
USP34 ubiquitin specific peptidase 34
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZNF217 zinc finger protein 217
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AK1 adenylate kinase 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
AQP1 aquaporin 1 (Colton blood group)
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
AURKA aurora kinase A
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BIRC5 baculoviral IAP repeat containing 5
C1QBP complement component 1, q subcomponent binding protein
C4BPA complement component 4 binding protein, alpha
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCNF cyclin F
CCR2 chemokine (C-C motif) receptor 2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPN centromere protein N
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIT citron rho-interacting serine/threonine kinase
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COTL1 coactosin-like F-actin binding protein 1
CSTA cystatin A (stefin A)
CTPS1 CTP synthase 1
CYCS cytochrome c, somatic
DCK deoxycytidine kinase
DCXR dicarbonyl/L-xylulose reductase
DHCR24 24-dehydrocholesterol reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EFS embryonal Fyn-associated substrate
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FGL2 fibrinogen-like 2
FHL1 four and a half LIM domains 1
FOXM1 forkhead box M1
FRZB frizzled-related protein
GINS2 GINS complex subunit 2 (Psf2 homolog)
GSTM3 glutathione S-transferase mu 3 (brain)
H2AFX H2A histone family, member X
HACD3 3-hydroxyacyl-CoA dehydratase 3
HBB hemoglobin, beta
HIST1H4C histone cluster 1, H4c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
HOXC10 homeobox C10
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPH1 heat shock 105kDa/110kDa protein 1
ICMT isoprenylcysteine carboxyl methyltransferase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INSIG1 insulin induced gene 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
ITM2A integral membrane protein 2A
JCHAIN joining chain of multimeric IgA and IgM
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT10 keratin 10, type I
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAGE3 L antigen family, member 3
LMNB1 lamin B1
LMNB2 lamin B2
LMO4 LIM domain only 4
LRRC59 leucine rich repeat containing 59
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTB lymphotoxin beta (TNF superfamily, member 3)
LTF lactotransferrin
LYZ lysozyme
MAOA monoamine oxidase A
MCM4 minichromosome maintenance complex component 4
MED21 mediator complex subunit 21
MELK maternal embryonic leucine zipper kinase
MFAP4 microfibrillar-associated protein 4
MLEC malectin
MOCS2 molybdenum cofactor synthesis 2
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa
NME1 NME/NM23 nucleoside diphosphate kinase 1
PA2G4 proliferation-associated 2G4, 38kDa
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCCB propionyl CoA carboxylase, beta polypeptide
PGAM1 phosphoglycerate mutase 1 (brain)
PGC progastricsin (pepsinogen C)
PHGDH phosphoglycerate dehydrogenase
PODXL podocalyxin-like
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
POSTN periostin, osteoblast specific factor
PPIC peptidylprolyl isomerase C (cyclophilin C)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRC1 protein regulator of cytokinesis 1
PRKCB protein kinase C, beta
PTGDS prostaglandin D2 synthase 21kDa (brain)
RACGAP1 Rac GTPase activating protein 1
RCAN2 regulator of calcineurin 2
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RIMS3 regulating synaptic membrane exocytosis 3
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC1 syndecan 1
SFN stratifin
SFTPB surfactant protein B
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPC25 SPC25, NDC80 kinetochore complex component
SPRR1B small proline-rich protein 1B
SRM spermidine synthase
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
SUB1 SUB1 homolog (S. cerevisiae)
TACC3 transforming, acidic coiled-coil containing protein 3
TCL1A T-cell leukemia/lymphoma 1A
TMEM45A transmembrane protein 45A
TMEM47 transmembrane protein 47
TMPO thymopoietin
TMX2 thioredoxin-related transmembrane protein 2
TP63 tumor protein p63
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIP13 thyroid hormone receptor interactor 13
TUBB4B tubulin, beta 4B class IVb
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBE2S ubiquitin-conjugating enzyme E2S
ZWINT ZW10 interacting kinetochore protein
Funding