BRD-A45540146_KI20227_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

78 genes differentially expressed following the BRD-A45540146_KI20227_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
BLNK B-cell linker
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
EIF5A eukaryotic translation initiation factor 5A
ENDOD1 endonuclease domain containing 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
KLF6 Kruppel-like factor 6
KRT6A keratin 6A, type II
MZB1 marginal zone B and B1 cell-specific protein
NQO1 NAD(P)H dehydrogenase, quinone 1
PCDH9 protocadherin 9
RAB25 RAB25, member RAS oncogene family
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SEPP1 selenoprotein P, plasma, 1
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SOCS2 suppressor of cytokine signaling 2
SSBP2 single-stranded DNA binding protein 2
TBXA2R thromboxane A2 receptor
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TNNT1 troponin T type 1 (skeletal, slow)
TPD52L1 tumor protein D52-like 1
TPST2 tyrosylprotein sulfotransferase 2
VDAC1 voltage-dependent anion channel 1

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALCAM activated leukocyte cell adhesion molecule
ANOS1 anosmin 1
AOC3 amine oxidase, copper containing 3
APOD apolipoprotein D
C14ORF132 chromosome 14 open reading frame 132
C8ORF4 chromosome 8 open reading frame 4
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CHRDL1 chordin-like 1
CLGN calmegin
COL15A1 collagen, type XV, alpha 1
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FAM46A family with sequence similarity 46, member A
GATA3 GATA binding protein 3
GEM GTP binding protein overexpressed in skeletal muscle
GPX3 glutathione peroxidase 3
GREB1 growth regulation by estrogen in breast cancer 1
IGF1 insulin-like growth factor 1 (somatomedin C)
ITFG1 integrin alpha FG-GAP repeat containing 1
JAG1 jagged 1
LRRN3 leucine rich repeat neuronal 3
MDK midkine (neurite growth-promoting factor 2)
MMP3 matrix metallopeptidase 3
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYH11 myosin, heavy chain 11, smooth muscle
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NELL2 NEL-like 2 (chicken)
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
NREP neuronal regeneration related protein
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLAC8 placenta-specific 8
PRPF4 pre-mRNA processing factor 4
PSIP1 PC4 and SFRS1 interacting protein 1
PYCARD PYD and CARD domain containing
RBP1 retinol binding protein 1, cellular
SCUBE2 signal peptide, CUB domain, EGF-like 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
THBS4 thrombospondin 4
TMSB15A thymosin beta 15a
TMX4 thioredoxin-related transmembrane protein 4
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
Funding