BRD-A46747628_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

231 genes differentially expressed following the BRD-A46747628_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADAM9 ADAM metallopeptidase domain 9
ADM adrenomedullin
AKAP8L A kinase (PRKA) anchor protein 8-like
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANKRD10 ankyrin repeat domain 10
ANXA3 annexin A3
AREG amphiregulin
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCL2A1 BCL2-related protein A1
BHLHE40 basic helix-loop-helix family, member e40
BRD4 bromodomain containing 4
BSG basigin (Ok blood group)
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
CA2 carbonic anhydrase II
CCNL1 cyclin L1
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CGA glycoprotein hormones, alpha polypeptide
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLC Charcot-Leyden crystal galectin
CLEC5A C-type lectin domain family 5, member A
COL15A1 collagen, type XV, alpha 1
COL6A1 collagen, type VI, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CPM carboxypeptidase M
CREB3L2 cAMP responsive element binding protein 3-like 2
CTGF connective tissue growth factor
CTSK cathepsin K
CTTN cortactin
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYR61 cysteine-rich, angiogenic inducer, 61
DEFA4 defensin, alpha 4, corticostatin
DHCR7 7-dehydrocholesterol reductase
DNMBP dynamin binding protein
EDN1 endothelin 1
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ELF1 E74-like factor 1 (ets domain transcription factor)
EPCAM epithelial cell adhesion molecule
EPHA3 EPH receptor A3
EREG epiregulin
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM46A family with sequence similarity 46, member A
FAM60A family with sequence similarity 60, member A
FASN fatty acid synthase
FNDC3B fibronectin type III domain containing 3B
FOXO1 forkhead box O1
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GPNMB glycoprotein (transmembrane) nmb
GSTM3 glutathione S-transferase mu 3 (brain)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GULP1 GULP, engulfment adaptor PTB domain containing 1
HCAR3 hydroxycarboxylic acid receptor 3
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGSF3 immunoglobulin superfamily, member 3
IL13RA2 interleukin 13 receptor, alpha 2
IL1R1 interleukin 1 receptor, type I
IL1R2 interleukin 1 receptor, type II
INSIG1 insulin induced gene 1
ISYNA1 inositol-3-phosphate synthase 1
JUN jun proto-oncogene
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KLF6 Kruppel-like factor 6
KLK5 kallikrein-related peptidase 5
LEPROT leptin receptor overlapping transcript
LRRC15 leucine rich repeat containing 15
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MFAP2 microfibrillar-associated protein 2
MFAP5 microfibrillar associated protein 5
MMP9 matrix metallopeptidase 9
MYO1D myosin ID
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRG1 neuregulin 1
NUPL1 nucleoporin like 1
PDE4DIP phosphodiesterase 4D interacting protein
PERP PERP, TP53 apoptosis effector
PLAGL1 pleiomorphic adenoma gene-like 1
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRMT1 protein arginine methyltransferase 1
PSPC1 paraspeckle component 1
PTPRO protein tyrosine phosphatase, receptor type, O
RBP4 retinol binding protein 4, plasma
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RYBP RING1 and YY1 binding protein
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC2 syndecan 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SNX7 sorting nexin 7
SON SON DNA binding protein
SOX4 SRY (sex determining region Y)-box 4
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRRM2 serine/arginine repetitive matrix 2
STOM stomatin
SULF1 sulfatase 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPM4 tropomyosin 4
TUFT1 tuftelin 1
WISP2 WNT1 inducible signaling pathway protein 2
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHNAK AHNAK nucleoprotein
AIM1 absent in melanoma 1
ALAD aminolevulinate dehydratase
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
AQP3 aquaporin 3 (Gill blood group)
ASB13 ankyrin repeat and SOCS box containing 13
ATMIN ATM interactor
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
B3GNT1
C6ORF62 chromosome 6 open reading frame 62
CAPN2 calpain 2, (m/II) large subunit
CAST calpastatin
CCND2 cyclin D2
CD14 CD14 molecule
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CES2 carboxylesterase 2
CFB complement factor B
COG2 component of oligomeric golgi complex 2
CSK c-src tyrosine kinase
CSTA cystatin A (stefin A)
CX3CR1 chemokine (C-X3-C motif) receptor 1
DENND2D DENN/MADD domain containing 2D
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DPYSL2 dihydropyrimidinase-like 2
DROSHA drosha, ribonuclease type III
EIF5 eukaryotic translation initiation factor 5
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
F12 coagulation factor XII (Hageman factor)
F13A1 coagulation factor XIII, A1 polypeptide
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GOLGA8H golgin A8 family, member H
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IL27RA interleukin 27 receptor, alpha
INTS3 integrator complex subunit 3
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JADE2 jade family PHD finger 2
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KCTD12 potassium channel tetramerization domain containing 12
KIAA0485 uncharacterized LOC57235
KLF4 Kruppel-like factor 4 (gut)
KRT15 keratin 15, type I
LGALS3 lectin, galactoside-binding, soluble, 3
LRRC8D leucine rich repeat containing 8 family, member D
MAN1C1 mannosidase, alpha, class 1C, member 1
MAPT microtubule-associated protein tau
MAT2A methionine adenosyltransferase II, alpha
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MSLN mesothelin
NMRK1 nicotinamide riboside kinase 1
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NR2F1 nuclear receptor subfamily 2, group F, member 1
NREP neuronal regeneration related protein
NUDCD3 NudC domain containing 3
PCYOX1L prenylcysteine oxidase 1 like
PDLIM2 PDZ and LIM domain 2 (mystique)
PEG10 paternally expressed 10
PLK2 polo-like kinase 2
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRKCA protein kinase C, alpha
PRUNE2 prune homolog 2 (Drosophila)
RAB31 RAB31, member RAS oncogene family
RBM34 RNA binding motif protein 34
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPS4Y1 ribosomal protein S4, Y-linked 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
S100A6 S100 calcium binding protein A6
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SPATS2L spermatogenesis associated, serine-rich 2-like
STEAP3 STEAP family member 3, metalloreductase
TBC1D31 TBC1 domain family, member 31
TMEM176B transmembrane protein 176B
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRIM14 tripartite motif containing 14
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN8 tetraspanin 8
TYROBP TYRO protein tyrosine kinase binding protein
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VCAN versican
XBP1 X-box binding protein 1
XPO7 exportin 7
XPOT exportin, tRNA
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF185 zinc finger protein 185 (LIM domain)
ZNF302 zinc finger protein 302