BRD-A48237631_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

196 genes differentially expressed following the BRD-A48237631_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL5 acyl-CoA synthetase long-chain family member 5
ADCK3 aarF domain containing kinase 3
ADRB2 adrenoceptor beta 2, surface
ALOX5 arachidonate 5-lipoxygenase
ANKRD10 ankyrin repeat domain 10
APLP2 amyloid beta (A4) precursor-like protein 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF5 activating transcription factor 5
BLCAP bladder cancer associated protein
BRD2 bromodomain containing 2
BTG2 BTG family, member 2
CCDC86 coiled-coil domain containing 86
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHPT1 choline phosphotransferase 1
CLU clusterin
CSTA cystatin A (stefin A)
CTSL cathepsin L
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLK1 delta-like 1 homolog (Drosophila)
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP14 dual specificity phosphatase 14
DUSP5 dual specificity phosphatase 5
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGR1 early growth response 1
EGR3 early growth response 3
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
FHL1 four and a half LIM domains 1
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FXYD3 FXYD domain containing ion transport regulator 3
FZD6 frizzled class receptor 6
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GCH1 GTP cyclohydrolase 1
GDF15 growth differentiation factor 15
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPX7 glutathione peroxidase 7
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER3 immediate early response 3
IER5 immediate early response 5
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INPP1 inositol polyphosphate-1-phosphatase
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KIAA0226L KIAA0226-like
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
LY6D lymphocyte antigen 6 complex, locus D
LY75 lymphocyte antigen 75
MAOA monoamine oxidase A
MICALL1 MICAL-like 1
MICB MHC class I polypeptide-related sequence B
MMP12 matrix metallopeptidase 12
MXI1 MAX interactor 1, dimerization protein
MYB v-myb avian myeloblastosis viral oncogene homolog
N4BP2L2 NEDD4 binding protein 2-like 2
NAMPT nicotinamide phosphoribosyltransferase
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFA platelet-derived growth factor alpha polypeptide
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PSAP prosaposin
RAD23B RAD23 homolog B (S. cerevisiae)
RGS2 regulator of G-protein signaling 2
RPS27L ribosomal protein S27-like
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SESN1 sestrin 1
SFN stratifin
SIAH2 siah E3 ubiquitin protein ligase 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC43A3 solute carrier family 43, member 3
SOCS1 suppressor of cytokine signaling 1
SORD sorbitol dehydrogenase
SRSF7 serine/arginine-rich splicing factor 7
STC2 stanniocalcin 2
TACSTD2 tumor-associated calcium signal transducer 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TP53 tumor protein p53
TRIM22 tripartite motif containing 22
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
UGDH UDP-glucose 6-dehydrogenase
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
ZDHHC6 zinc finger, DHHC-type containing 6
ZFP36L1 ZFP36 ring finger protein-like 1
ZMAT3 zinc finger, matrin-type 3
ZW10 zw10 kinetochore protein

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
AGTR1 angiotensin II receptor, type 1
AMIGO2 adhesion molecule with Ig-like domain 2
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
AURKB aurora kinase B
CCNB1 cyclin B1
CCNB2 cyclin B2
CCNF cyclin F
CD44 CD44 molecule (Indian blood group)
CDCA3 cell division cycle associated 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CIT citron rho-interacting serine/threonine kinase
COL4A2 collagen, type IV, alpha 2
COMP cartilage oligomeric matrix protein
COTL1 coactosin-like F-actin binding protein 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CST7 cystatin F (leukocystatin)
DACH1 dachshund family transcription factor 1
DAPK1 death-associated protein kinase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHA3 EPH receptor A3
EZR ezrin
FABP7 fatty acid binding protein 7, brain
FN1 fibronectin 1
FNBP1L formin binding protein 1-like
FOLR1 folate receptor 1 (adult)
FST follistatin
GPSM2 G-protein signaling modulator 2
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
H2AFY H2A histone family, member Y
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IPO7 importin 7
ITGA6 integrin, alpha 6
ITM2A integral membrane protein 2A
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LYZ lysozyme
MXRA7 matrix-remodelling associated 7
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NRCAM neuronal cell adhesion molecule
NRG1 neuregulin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NTS neurotensin
PAM peptidylglycine alpha-amidating monooxygenase
PDE4B phosphodiesterase 4B, cAMP-specific
PEG10 paternally expressed 10
PHACTR2 phosphatase and actin regulator 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCB4 phospholipase C, beta 4
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLK1 polo-like kinase 1
PON3 paraoxonase 3
PSRC1 proline/serine-rich coiled-coil 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RGS5 regulator of G-protein signaling 5
RHOBTB1 Rho-related BTB domain containing 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SNX7 sorting nexin 7
SOX11 SRY (sex determining region Y)-box 11
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SYT1 synaptotagmin I
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX3 TOX high mobility group box family member 3
TPM4 tropomyosin 4
TTK TTK protein kinase
UBE2C ubiquitin-conjugating enzyme E2C
VCAM1 vascular cell adhesion molecule 1
ZIC1 Zic family member 1
ZMIZ1 zinc finger, MIZ-type containing 1
Funding