BRD-A48237631_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-A48237631_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AIM2 absent in melanoma 2
AKAP8 A kinase (PRKA) anchor protein 8
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit
ANXA1 annexin A1
ARL4C ADP-ribosylation factor-like 4C
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLCA4 chloride channel accessory 4
CLDND1 claudin domain containing 1
CREBL2 cAMP responsive element binding protein-like 2
CSTA cystatin A (stefin A)
CTTN cortactin
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
CXCR4 chemokine (C-X-C motif) receptor 4
CYBRD1 cytochrome b reductase 1
DLX2 distal-less homeobox 2
DUSP14 dual specificity phosphatase 14
EFNB2 ephrin-B2
EGFL6 EGF-like-domain, multiple 6
EMP1 epithelial membrane protein 1
ENO2 enolase 2 (gamma, neuronal)
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FXYD3 FXYD domain containing ion transport regulator 3
GABARAPL1 GABA(A) receptor-associated protein like 1
GATA2 GATA binding protein 2
GATA3 GATA binding protein 3
GBP2 guanylate binding protein 2, interferon-inducible
GLA galactosidase, alpha
GOLGA8B golgin A8 family, member B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXB6 homeobox B6
IDO1 indoleamine 2,3-dioxygenase 1
IGFBP5 insulin-like growth factor binding protein 5
INA internexin neuronal intermediate filament protein, alpha
JCHAIN joining chain of multimeric IgA and IgM
KLF4 Kruppel-like factor 4 (gut)
KLHL21 kelch-like family member 21
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT5 keratin 5, type II
KYNU kynureninase
LUM lumican
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MFAP5 microfibrillar associated protein 5
MIR22HG MIR22 host gene
MTL5 metallothionein-like 5, testis-specific (tesmin)
NELL2 NEL-like 2 (chicken)
NLRP2 NLR family, pyrin domain containing 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
OAT ornithine aminotransferase
PEA15 phosphoprotein enriched in astrocytes 15
PERP PERP, TP53 apoptosis effector
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
RALGDS ral guanine nucleotide dissociation stimulator
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGS2 regulator of G-protein signaling 2
SCGB2A2 secretoglobin, family 2A, member 2
SESN1 sestrin 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SNAI2 snail family zinc finger 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TJP1 tight junction protein 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPD52L1 tumor protein D52-like 1
TRBC1 T cell receptor beta constant 1
TRIM2 tripartite motif containing 2
UBE3B ubiquitin protein ligase E3B
VAMP3 vesicle-associated membrane protein 3
VIM vimentin
VTCN1 V-set domain containing T cell activation inhibitor 1
WARS tryptophanyl-tRNA synthetase
XIST X inactive specific transcript (non-protein coding)
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
APOD apolipoprotein D
ARID4B AT rich interactive domain 4B (RBP1-like)
BEX1 brain expressed, X-linked 1
CCNA2 cyclin A2
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CST1 cystatin SN
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CYTL1 cytokine-like 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FASN fatty acid synthase
FOLR1 folate receptor 1 (adult)
FOXJ3 forkhead box J3
GPSM2 G-protein signaling modulator 2
GPX2 glutathione peroxidase 2
HOMER1 homer scaffolding protein 1
HSPA8 heat shock 70kDa protein 8
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KIF14 kinesin family member 14
LPP LIM domain containing preferred translocation partner in lipoma
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MNAT1 MNAT CDK-activating kinase assembly factor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIB nuclear factor I/B
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
ODAM odontogenic, ameloblast asssociated
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PWP1 PWP1 homolog (S. cerevisiae)
QPRT quinolinate phosphoribosyltransferase
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SOBP sine oculis binding protein homolog (Drosophila)
SPATS2L spermatogenesis associated, serine-rich 2-like
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TSKU tsukushi, small leucine rich proteoglycan
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5
WIPF2 WAS/WASL interacting protein family, member 2
ZFP36L2 ZFP36 ring finger protein-like 2
Funding