BRD-A48570745_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-A48570745_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALCAM activated leukocyte cell adhesion molecule
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BGN biglycan
BMP6 bone morphogenetic protein 6
BTG2 BTG family, member 2
C1ORF116 chromosome 1 open reading frame 116
CADM1 cell adhesion molecule 1
CCDC86 coiled-coil domain containing 86
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
COMP cartilage oligomeric matrix protein
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
EGR1 early growth response 1
FOXG1 forkhead box G1
FST follistatin
GADD45B growth arrest and DNA-damage-inducible, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HOPX HOP homeobox
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
MAGEA3 melanoma antigen family A3
MAP7 microtubule-associated protein 7
MB myoglobin
MEF2C myocyte enhancer factor 2C
MFAP2 microfibrillar-associated protein 2
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NOTCH2NL notch 2 N-terminal like
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PSAT1 phosphoserine aminotransferase 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
SAT1 spermidine/spermine N1-acetyltransferase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STC2 stanniocalcin 2
THBD thrombomodulin
THBS1 thrombospondin 1
TRIB3 tribbles pseudokinase 3
TTN titin
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
WIF1 WNT inhibitory factor 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANXA3 annexin A3
AP2M1 adaptor-related protein complex 2, mu 1 subunit
BACE2 beta-site APP-cleaving enzyme 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAPNS1 calpain, small subunit 1
CAV2 caveolin 2
CCNF cyclin F
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
DERA deoxyribose-phosphate aldolase (putative)
GNAS GNAS complex locus
GPI glucose-6-phosphate isomerase
GPX3 glutathione peroxidase 3
IRS2 insulin receptor substrate 2
KIAA1033 KIAA1033
LY6E lymphocyte antigen 6 complex, locus E
NME4 NME/NM23 nucleoside diphosphate kinase 4
OLFM1 olfactomedin 1
OLFM4 olfactomedin 4
PDZK1IP1 PDZK1 interacting protein 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PPIG peptidylprolyl isomerase G (cyclophilin G)
PRDX2 peroxiredoxin 2
RNF130 ring finger protein 130
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A10 S100 calcium binding protein A10
S100A2 S100 calcium binding protein A2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFA transforming growth factor, alpha
TGM2 transglutaminase 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TUBA1A tubulin, alpha 1a
UBE3C ubiquitin protein ligase E3C
WNT5A wingless-type MMTV integration site family, member 5A
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZW10 zw10 kinetochore protein
Funding