BRD-A49680073_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

127 genes differentially expressed following the BRD-A49680073_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN1 actinin, alpha 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BEX4 brain expressed, X-linked 4
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
CARS cysteinyl-tRNA synthetase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CLEC2B C-type lectin domain family 2, member B
COL5A2 collagen, type V, alpha 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EIF5 eukaryotic translation initiation factor 5
EMP1 epithelial membrane protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45B growth arrest and DNA-damage-inducible, beta
GCLM glutamate-cysteine ligase, modifier subunit
GULP1 GULP, engulfment adaptor PTB domain containing 1
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFRD1 interferon-related developmental regulator 1
IL32 interleukin 32
ILK integrin-linked kinase
ISG20 interferon stimulated exonuclease gene 20kDa
KLF6 Kruppel-like factor 6
KRT18 keratin 18, type I
KRT7 keratin 7, type II
LAPTM5 lysosomal protein transmembrane 5
LBH limb bud and heart development
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MIR22HG MIR22 host gene
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYL9 myosin, light chain 9, regulatory
MYOF myoferlin
NFIL3 nuclear factor, interleukin 3 regulated
NRIP1 nuclear receptor interacting protein 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RB1CC1 RB1-inducible coiled-coil 1
RHOC ras homolog family member C
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
SDC4 syndecan 4
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERTAD2 SERTA domain containing 2
SH3GLB1 SH3-domain GRB2-like endophilin B1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
TAGLN transgelin
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TPD52 tumor protein D52
TUBB2A tubulin, beta 2A class IIa
TXNRD1 thioredoxin reductase 1
UPP1 uridine phosphorylase 1
ZYX zyxin

decreased expression

Symbol Name
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
CAST calpastatin
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CYFIP2 cytoplasmic FMR1 interacting protein 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FGFR3 fibroblast growth factor receptor 3
GPX3 glutathione peroxidase 3
HSPA8 heat shock 70kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
IGFBP7 insulin-like growth factor binding protein 7
LDHB lactate dehydrogenase B
LEPR leptin receptor
MCAM melanoma cell adhesion molecule
MFSD10 major facilitator superfamily domain containing 10
NR2F2 nuclear receptor subfamily 2, group F, member 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLAT plasminogen activator, tissue
POSTN periostin, osteoblast specific factor
PSD3 pleckstrin and Sec7 domain containing 3
PXMP2 peroxisomal membrane protein 2, 22kDa
RRP1B ribosomal RNA processing 1B
SDC2 syndecan 2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
TFRC transferrin receptor
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM243 transmembrane protein 243, mitochondrial
TSPAN12 tetraspanin 12
TSPAN7 tetraspanin 7
VCAN versican
XYLT1 xylosyltransferase I
Funding