BRD-A50774520_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-A50774520_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
ANKRD10 ankyrin repeat domain 10
ANKRD12 ankyrin repeat domain 12
ARID5B AT rich interactive domain 5B (MRF1-like)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BCL6 B-cell CLL/lymphoma 6
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CLU clusterin
COL6A2 collagen, type VI, alpha 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDIT3 DNA-damage-inducible transcript 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR3 early growth response 3
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAM57A family with sequence similarity 57, member A
FMOD fibromodulin
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
FRY furry homolog (Drosophila)
GADD45B growth arrest and DNA-damage-inducible, beta
GATA2 GATA binding protein 2
GEM GTP binding protein overexpressed in skeletal muscle
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFRD1 interferon-related developmental regulator 1
INPP1 inositol polyphosphate-1-phosphatase
IRS2 insulin receptor substrate 2
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KIAA0226L KIAA0226-like
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MEG3 maternally expressed 3 (non-protein coding)
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MT1M metallothionein 1M
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NCAM1 neural cell adhesion molecule 1
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPR1 nuclear protein, transcriptional regulator, 1
PCDH9 protocadherin 9
PDGFA platelet-derived growth factor alpha polypeptide
PEG3 paternally expressed 3
PELI1 pellino E3 ubiquitin protein ligase 1
PLAC8 placenta-specific 8
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTPN2 protein tyrosine phosphatase, non-receptor type 2
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
S100A9 S100 calcium binding protein A9
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SERTAD2 SERTA domain containing 2
SFN stratifin
SHOX2 short stature homeobox 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLPI secretory leukocyte peptidase inhibitor
SPP1 secreted phosphoprotein 1
TMEM45A transmembrane protein 45A
TNC tenascin C
TRIB1 tribbles pseudokinase 1
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
TXNRD1 thioredoxin reductase 1
TYMP thymidine phosphorylase
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ADIPOQ adiponectin, C1Q and collagen domain containing
AREG amphiregulin
AURKA aurora kinase A
BMI1 BMI1 proto-oncogene, polycomb ring finger
CCNA2 cyclin A2
CD59 CD59 molecule, complement regulatory protein
CDK1 cyclin-dependent kinase 1
CIRBP cold inducible RNA binding protein
ERBB3 erb-b2 receptor tyrosine kinase 3
EREG epiregulin
GINS1 GINS complex subunit 1 (Psf1 homolog)
GRWD1 glutamate-rich WD repeat containing 1
IER3 immediate early response 3
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LEPROTL1 leptin receptor overlapping transcript-like 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LYPLA1 lysophospholipase I
MCAM melanoma cell adhesion molecule
MLEC malectin
NRP1 neuropilin 1
PLIN1 perilipin 1
PLK1 polo-like kinase 1
PLN phospholamban
PSPH phosphoserine phosphatase
RFTN1 raftlin, lipid raft linker 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBC1D16 TBC1 domain family, member 16
TFF1 trefoil factor 1
THBS1 thrombospondin 1
USP22 ubiquitin specific peptidase 22