BRD-A51777634_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

77 genes differentially expressed following the BRD-A51777634_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AGR2 anterior gradient 2
AK4 adenylate kinase 4
ALDOC aldolase C, fructose-bisphosphate
BHLHE40 basic helix-loop-helix family, member e40
BLCAP bladder cancer associated protein
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
DDIT4 DNA-damage-inducible transcript 4
DLK1 delta-like 1 homolog (Drosophila)
EGLN3 egl-9 family hypoxia-inducible factor 3
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
FAM162A family with sequence similarity 162, member A
FAM46A family with sequence similarity 46, member A
FAM57A family with sequence similarity 57, member A
FOS FBJ murine osteosarcoma viral oncogene homolog
GADD45B growth arrest and DNA-damage-inducible, beta
GBE1 glucan (1,4-alpha-), branching enzyme 1
GPI glucose-6-phosphate isomerase
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
IER3 immediate early response 3
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
LOX lysyl oxidase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MKNK2 MAP kinase interacting serine/threonine kinase 2
MT1X metallothionein 1X
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NFIL3 nuclear factor, interleukin 3 regulated
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PNMA2 paraneoplastic Ma antigen 2
RALGDS ral guanine nucleotide dissociation stimulator
RIOK3 RIO kinase 3
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SIK1 salt-inducible kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
STC1 stanniocalcin 1
STC2 stanniocalcin 2
TFF3 trefoil factor 3 (intestinal)
TMEM45A transmembrane protein 45A
TNNC1 troponin C type 1 (slow)
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor

decreased expression

Symbol Name
AURKA aurora kinase A
CENPF centromere protein F, 350/400kDa
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
GTSE1 G-2 and S-phase expressed 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HSPA1A heat shock 70kDa protein 1A
IGL immunoglobulin lambda locus
KCTD12 potassium channel tetramerization domain containing 12
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KYNU kynureninase
LPAR6 lysophosphatidic acid receptor 6
LTF lactotransferrin
PLK1 polo-like kinase 1
PSRC1 proline/serine-rich coiled-coil 1
SMAD1 SMAD family member 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
UBE2C ubiquitin-conjugating enzyme E2C
Funding