BRD-A52530684_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

302 genes differentially expressed following the BRD-A52530684_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADAM9 ADAM metallopeptidase domain 9
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AEBP1 AE binding protein 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALOX5 arachidonate 5-lipoxygenase
ANXA11 annexin A11
ANXA4 annexin A4
ANXA9 annexin A9
AQP1 aquaporin 1 (Colton blood group)
BLNK B-cell linker
BLVRB biliverdin reductase B
BSG basigin (Ok blood group)
C9ORF16 chromosome 9 open reading frame 16
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CD47 CD47 molecule
CD99 CD99 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CECR1 cat eye syndrome chromosome region, candidate 1
CETN2 centrin, EF-hand protein, 2
CFB complement factor B
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLDN3 claudin 3
CLIC5 chloride intracellular channel 5
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A1 collagen, type VI, alpha 1
COL6A3 collagen, type VI, alpha 3
CPM carboxypeptidase M
CYBB cytochrome b-245, beta polypeptide
DCN decorin
EFHD1 EF-hand domain family, member D1
EGFL6 EGF-like-domain, multiple 6
EIF5A eukaryotic translation initiation factor 5A
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EXPH5 exophilin 5
FAM134B family with sequence similarity 134, member B
FILIP1L filamin A interacting protein 1-like
GLG1 golgi glycoprotein 1
GMPR guanosine monophosphate reductase
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPX3 glutathione peroxidase 3
GSN gelsolin
H2AFY H2A histone family, member Y
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IFT57 intraflagellar transport 57
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
LRRC15 leucine rich repeat containing 15
LRRC17 leucine rich repeat containing 17
LTB lymphotoxin beta (TNF superfamily, member 3)
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
MMP1 matrix metallopeptidase 1
MXRA5 matrix-remodelling associated 5
NMU neuromedin U
NUPR1 nuclear protein, transcriptional regulator, 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PECAM1 platelet/endothelial cell adhesion molecule 1
PFKM phosphofructokinase, muscle
PLAU plasminogen activator, urokinase
PLVAP plasmalemma vesicle associated protein
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSENEN presenilin enhancer gamma secretase subunit
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS5 regulator of G-protein signaling 5
S100A8 S100 calcium binding protein A8
SCARB2 scavenger receptor class B, member 2
SCG5 secretogranin V
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELENBP1 selenium binding protein 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STC1 stanniocalcin 1
SULF1 sulfatase 1
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TNNC1 troponin C type 1 (slow)
TPP1 tripeptidyl peptidase I
TSPAN31 tetraspanin 31
TUBA1A tubulin, alpha 1a
VTCN1 V-set domain containing T cell activation inhibitor 1
WISP2 WNT1 inducible signaling pathway protein 2

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADM adrenomedullin
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADORA2B adenosine A2b receptor
ADRB2 adrenoceptor beta 2, surface
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ASXL2 additional sex combs like transcriptional regulator 2
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
BLCAP bladder cancer associated protein
BTG1 B-cell translocation gene 1, anti-proliferative
CAPN6 calpain 6
CCDC59 coiled-coil domain containing 59
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CENPA centromere protein A
CHD1 chromodomain helicase DNA binding protein 1
CHERP calcium homeostasis endoplasmic reticulum protein
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CKS2 CDC28 protein kinase regulatory subunit 2
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
COIL coilin
CREBBP CREB binding protein
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DBF4 DBF4 zinc finger
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP2 dual specificity phosphatase 2
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EED embryonic ectoderm development
ELL2 elongation factor, RNA polymerase II, 2
EPHA2 EPH receptor A2
ETV5 ets variant 5
EXOSC4 exosome component 4
FADD Fas (TNFRSF6)-associated via death domain
FAM46A family with sequence similarity 46, member A
FASTKD5 FAST kinase domains 5
FBXL14 F-box and leucine-rich repeat protein 14
FHL2 four and a half LIM domains 2
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FOXC1 forkhead box C1
FOXJ3 forkhead box J3
GEM GTP binding protein overexpressed in skeletal muscle
GEMIN4 gem (nuclear organelle) associated protein 4
GOSR1 golgi SNAP receptor complex member 1
GRWD1 glutamate-rich WD repeat containing 1
GSPT2 G1 to S phase transition 2
H2AFX H2A histone family, member X
HEXIM1 hexamethylene bis-acetamide inducible 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOMER1 homer scaffolding protein 1
HOXA10 homeobox A10
HOXA5 homeobox A5
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INTS6 integrator complex subunit 6
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
IST1 increased sodium tolerance 1 homolog (yeast)
JMJD6 jumonji domain containing 6
KAT6A K(lysine) acetyltransferase 6A
KDM2A lysine (K)-specific demethylase 2A
KEAP1 kelch-like ECH-associated protein 1
KIAA0907 KIAA0907
KIF2A kinesin heavy chain member 2A
KLHL21 kelch-like family member 21
KRT14 keratin 14, type I
KRT7 keratin 7, type II
LHX2 LIM homeobox 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK6 mitogen-activated protein kinase 6
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MED13 mediator complex subunit 13
MED17 mediator complex subunit 17
MRPS2 mitochondrial ribosomal protein S2
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
MTF2 metal response element binding transcription factor 2
MUC5B mucin 5B, oligomeric mucus/gel-forming
NCK1 NCK adaptor protein 1
NET1 neuroepithelial cell transforming 1
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOL11 nucleolar protein 11
NOP16 NOP16 nucleolar protein
NOTCH2NL notch 2 N-terminal like
NUP62 nucleoporin 62kDa
NXT1 nuclear transport factor 2-like export factor 1
PDE4D phosphodiesterase 4D, cAMP-specific
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK1 polo-like kinase 1
PNN pinin, desmosome associated protein
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD)
PPIF peptidylprolyl isomerase F
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRPF4 pre-mRNA processing factor 4
PRPF4B pre-mRNA processing factor 4B
PTX3 pentraxin 3, long
PXDC1 PX domain containing 1
RANBP6 RAN binding protein 6
RBM14 RNA binding motif protein 14
RBM15 RNA binding motif protein 15
RGS2 regulator of G-protein signaling 2
RLF rearranged L-myc fusion
RNF4 ring finger protein 4
RPL36 ribosomal protein L36
RPL37A ribosomal protein L37a
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUNX3 runt-related transcription factor 3
RYBP RING1 and YY1 binding protein
S100P S100 calcium binding protein P
SACS sacsin molecular chaperone
SAP30 Sin3A-associated protein, 30kDa
SCAF4 SR-related CTD-associated factor 4
SCAF8 SR-related CTD-associated factor 8
SCAND1 SCAN domain containing 1
SECISBP2L SECIS binding protein 2-like
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERTAD2 SERTA domain containing 2
SETD5 SET domain containing 5
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SIX2 SIX homeobox 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC22A3 solute carrier family 22 (organic cation transporter), member 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD7 SMAD family member 7
SOWAHC sosondowah ankyrin repeat domain family member C
SOX9 SRY (sex determining region Y)-box 9
SPEN spen family transcriptional repressor
SPHK1 sphingosine kinase 1
SPRY2 sprouty homolog 2 (Drosophila)
SRSF2 serine/arginine-rich splicing factor 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNJ2 synaptojanin 2
TACC2 transforming, acidic coiled-coil containing protein 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TBP TATA box binding protein
TBX3 T-box 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TEX10 testis expressed 10
TFF3 trefoil factor 3 (intestinal)
THUMPD1 THUMP domain containing 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TNPO1 transportin 1
TOB1 transducer of ERBB2, 1
TOB2 transducer of ERBB2, 2
TSC22D2 TSC22 domain family, member 2
TXLNA taxilin alpha
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UGCG UDP-glucose ceramide glucosyltransferase
USP1 ubiquitin specific peptidase 1
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VGLL4 vestigial-like family member 4
WAPAL wings apart-like homolog (Drosophila)
WDR82 WD repeat domain 82
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
YTHDC1 YTH domain containing 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZCCHC2 zinc finger, CCHC domain containing 2
ZCCHC8 zinc finger, CCHC domain containing 8
ZFP36L2 ZFP36 ring finger protein-like 2
ZMYM2 zinc finger, MYM-type 2
ZNF263 zinc finger protein 263
ZNF84 zinc finger protein 84